Zobrazeno 1 - 10
of 73
pro vyhledávání: '"W C Vass"'
Publikováno v:
Molecular and Cellular Biology. 11:6026-6033
We have previously used a series of insertion-deletion mutants of the mutationally activated v-rasH gene to identify several regions of the encoded protein that are dispensable for cellular transformation (B. M. Willumsen, A. G. Papageorge, H.-F. Kun
Publikováno v:
Molecular and Cellular Biology. 13:6799-6809
Morphological transformation of NIH 3T3 cells was observed following coexpression of a portion of the ras GTPase-activating protein (GAP) comprising the amino terminus (GAP-N) and a mutant of v-src (MDSRC) lacking the membrane-localizing sequence. Ce
Autor:
R, Wienecke, J C, Maize, F, Shoarinejad, W C, Vass, J, Reed, J S, Bonifacino, J H, Resau, J, de Gunzburg, R S, Yeung, J E, DeClue
Publikováno v:
Oncogene. 13(5)
Tuberin is the protein product of the tuberous sclerosis-2 (TSC2) gene, which is associated with tuberous sclerosis (TSC), a human genetic syndrome characterized by the development of tumors in a variety of tissues. We have previously shown that tube
Autor:
D R, Lowy, M R, Johnson, J E, DeClue, H, Cen, K, Zhang, A G, Papageorge, W C, Vass, B M, Willumsen, M B, Valentine, A T, Look
Publikováno v:
Ciba Foundation symposium. 176
We are studying the biological activity and regulation of mammalian Ras protein in tumours and in physiological signalling. We have shown that GAP (the GTPase-activating protein) is a potent negative regulator of normal Ras in cells. Reduction or los
Publikováno v:
The New biologist. 3(4)
A variety of cancer cells overexpress transforming growth factor alpha (TGF alpha), a mitogenic peptide. A cDNA sequence coding for the full-length human TGF alpha precursor protein was subcloned into a retroviral expression vector and introduced int
Publikováno v:
Cancer research. 51(2)
We have investigated the inhibition of cell growth by lovastatin (previously known as mevinolin), an antagonist of hydroxymethylglutaryl coenzyme A reductase which blocks the processing and membrane localization of ras proteins via inhibition of poly
Publikováno v:
Oncogene research. 5(3)
Human c-fps/fes when expressed at sufficiently high levels in NIH 3T3 cells can induce cellular transformation. To probe the mechanism of action of the c-fps/fes product NCP92, we have examined the biological and biochemical consequences of stabilizi
Publikováno v:
Oncogene. 3(3)
A cloned line of S + L- mink lung cells (A clone), which exhibited a flat morphology, was superinfected with a novel dual-tropic virus (E1BX-MuLV) showing a broad host range and a B-tropism. These cells gave rise to transformed cells with two phenoty
Publikováno v:
Oncogene research. 1(4)
We have generated a cDNA copy of human c-fps/fes from a 13 kb genomic DNA by means of a retroviral shuttle vector, and have begun characterization of its biological and biochemical properties. The cDNA was able to direct the in vitro synthesis of a p
Publikováno v:
Food & Function; Nov2020, Vol. 11 Issue 11, p9573-9584, 12p