Zobrazeno 1 - 10
of 109
pro vyhledávání: '"W C Duane"'
Autor:
W C Duane
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 6, Pp 1120-1128 (1997)
Legume consumption appears to lower serum cholesterol and to increase cholesterol saturation of bile, but the mechanisms of these effects have not been established. We studied nine human subjects on a metabolic ward during two randomly ordered 6-7 we
Externí odkaz:
https://doaj.org/article/9f3d0d46e71046c490339a5da7662b0a
Autor:
W C Duane
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 1, Pp 183-188 (1997)
In hypertriglyceridemic subjects, bile acid synthesis measured by isotope dilution is consistently higher than synthesis measured by fecal acidic sterol output. To see which of these two measurements was the more accurate, we compared them to synthes
Externí odkaz:
https://doaj.org/article/474b0fd2d67247d8ad7c91dd99444bcd
Publikováno v:
Journal of Lipid Research, Vol 37, Iss 2, Pp 431-436 (1996)
Bile acids labeled with 3H on the sterol nucleus lose a substantial fraction of label during enterohepatic cycling and conversion to secondary bile acids. We tested the isotopic stability of a side-chain 3H label, [22,23-3H]cholic acid in humans. The
Externí odkaz:
https://doaj.org/article/d0e16e971021486b94e7b259fb7d2d9e
Autor:
W C Duane
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 2, Pp 343-348 (1995)
We measured serum lathosterol levels and whole body cholesterol synthesis by sterol balance in 12 human subjects on a metabolic ward in four randomly allocated, 6-7 week periods: 1) lovastatin (40 mg b.i.d.) + low cholesterol diet (mean 246 mg/day);
Externí odkaz:
https://doaj.org/article/4554bf1277e647faa600d5bcb0edb27b
Autor:
W C Duane
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 1, Pp 96-107 (1995)
To better define the abnormality of bile acid metabolism associated with hypertriglyceridemia, we measured bile acid kinetics and absorption as well as preferential use of newly synthesized cholesterol for bile acid synthesis in eleven controls and t
Externí odkaz:
https://doaj.org/article/6aa7445e26e14dfe8a2ed45320c6fe18
Autor:
D S Hanson, W C Duane
Publikováno v:
Journal of Lipid Research, Vol 35, Iss 8, Pp 1462-1468 (1994)
To assess the relationship between cholesterol synthesis and feedback inhibition of bile acid synthesis, we studied seven normal human subjects taking three different doses of chenodiol, 0, 5, and 15 mg/kg per day: once while taking no lovastatin and
Externí odkaz:
https://doaj.org/article/6abd2b3ed26c40bfb25bd11a7edcce58
Autor:
W C Duane
Publikováno v:
Journal of Lipid Research, Vol 35, Iss 3, Pp 501-509 (1994)
We measured bile acid kinetics and bile lipids in 12 human subjects on a metabolic ward in four randomly allocated, 6-7 week periods: 1) lovastatin (40 mg b.i.d) + low cholesterol diet (mean 246 mg/day); 2) lovastatin+high cholesterol diet (mean 1071
Externí odkaz:
https://doaj.org/article/a43c0c41c904497a99094721df367926
Publikováno v:
Journal of Lipid Research, Vol 24, Iss 2, Pp 141-146 (1983)
Synthesis of bile salts is regulated through negative feedback inhibition by bile salts returning to the liver. Individual bile salts have not been distinguished with regard to inhibitory potential. We assessed inhibition of bile salt synthesis by ei
Externí odkaz:
https://doaj.org/article/a26fbfc9b54847b584863aa087169a07
Publikováno v:
Journal of Lipid Research, Vol 17, Iss 3, Pp 211-219 (1976)
The effects of a four to six day fast on gallbladder bile lipid composition, bile acid pool size, bile acid composition, and cholic acid metabolism have been determined in normal human subjects. Total bile acid pool size and cholic acid pool size wer
Externí odkaz:
https://doaj.org/article/0a71db8c10044b2c98756c2c5e275d27
Publikováno v:
Journal of Lipid Research, Vol 25, Iss 5, Pp 523-526 (1984)
The carcinogen 3-methylcholanthrene can be produced from deoxycholic acid and is postulated by some investigators to play a role in the pathogenesis of colon carcinoma. The small quantities of this compound which could be carcinogenic have been diffi
Externí odkaz:
https://doaj.org/article/7c58a2c8e85a487385dff8ef925e3774