Zobrazeno 1 - 10
of 17
pro vyhledávání: '"W C Clay"'
Autor:
Shilina Roman, SC Lappin, Laura J. Chambers, FS Cusdin, Daryl S. Walter, Anton D. Michel, Elena Fonfria, J Reeves, W C Clay, J A Goodwin
Publikováno v:
British Journal of Pharmacology. 158:1513-1526
Background and purpose: Human and rodent P2X7 receptors exhibit differences in their sensitivity to antagonists. In this study we have cloned and characterized the dog P2X7 receptor to determine if its antagonist sensitivity more closely resembles th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8412016a2211fb0e1b27fc5f3b7875e
https://doi.org/10.1111/j.1476-5381.2009.00425.x
https://doi.org/10.1111/j.1476-5381.2009.00425.x
Autor:
S W Ng, K Thompson, M.R.P. Hall, Anton D. Michel, Stefan Senger, J P Condreay, Shilina Roman, Livermore David, W C Clay, J Holbrook
Publikováno v:
British Journal of Pharmacology. 155:738-751
Background and purpose: Several P2X7 receptor antagonists are allosteric inhibitors and exhibit species difference in potency. Furthermore, N2-(3,4-difluorophenyl)-N1-(2-methyl-5-(1-piperazinylmethyl)phenyl)glycinamide dihydrochloride (GW791343) exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea4d80b2aa745bd6ab67645d6e34e15f
https://doi.org/10.1038/bjp.2008.306
https://doi.org/10.1038/bjp.2008.306
Autor:
Anton D. Michel, D S Levy, J P Condreay, W C Clay, J A Goodwin, Elena Fonfria, G D Smith, Shilina Roman
Publikováno v:
British Journal of Pharmacology. 153:544-556
Background and purpose: The human, rat, and mouse P2X7 receptors have been previously characterized, and in this study we report the cloning and pharmacological properties of the guinea pig orthologue. Experimental approach: A cDNA encoding for the g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4df0c4637904a08d389513cab8b387ad
https://doi.org/10.1038/sj.bjp.0707596
https://doi.org/10.1038/sj.bjp.0707596
Autor:
Iain P. Chessell, Anton D. Michel, Laura J. Chambers, W C Clay, Daryl S. Walter, J P Condreay
Publikováno v:
British Journal of Pharmacology. 151:84-95
Background and Purpose: The P2X7 receptor exhibits complex pharmacological properties. In this study, binding of a [3H]-labelled P2X7 receptor antagonist to human P2X7 receptors has been examined to further understand ligand interactions with this re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed691a1366cfce3cbca0ffceb24fda97
https://doi.org/10.1038/sj.bjp.0707196
https://doi.org/10.1038/sj.bjp.0707196
Publikováno v:
The Journal of Immunology. 153:712-723
In these studies, we show that NF-kappa B induces transcription from the human pro-IL-1 beta (IL-1 beta) gene. A recombinant plasmid pIL-1(-4000)-CAT, containing 4 kb of the IL-1 beta gene upstream regulatory sequence was transactivated by the p65 su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bee2b2842e0b1aeb453f63b809aa0af6
https://doi.org/10.4049/jimmunol.153.2.712
https://doi.org/10.4049/jimmunol.153.2.712
Autor:
A D, Michel, W C, Clay, S W, Ng, S, Roman, K, Thompson, J P, Condreay, M, Hall, J, Holbrook, D, Livermore, S, Senger
Publikováno v:
British journal of pharmacology. 155(5)
Several P2X(7) receptor antagonists are allosteric inhibitors and exhibit species difference in potency. Furthermore, N(2)-(3,4-difluorophenyl)-N(1)-(2-methyl-5-(1-piperazinylmethyl)phenyl)glycinamide dihydrochloride (GW791343) exhibits negative allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2066190402261f64fd89b2be6292cba
https://pubmed.ncbi.nlm.nih.gov/18660826
https://pubmed.ncbi.nlm.nih.gov/18660826
Publikováno v:
British journal of pharmacology. 151(1)
The P2X(7) receptor exhibits complex pharmacological properties. In this study, binding of a [(3)H]-labelled P2X(7) receptor antagonist to human P2X(7) receptors has been examined to further understand ligand interactions with this receptor.The P2X(7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c4d020619144b290dea9340a14d08cb
https://pubmed.ncbi.nlm.nih.gov/17339830
https://pubmed.ncbi.nlm.nih.gov/17339830
Publikováno v:
Journal of virology. 75(2)
Our group and others have recently demonstrated the ability of recombinant baculoviruses to transduce mammalian cells at high frequency. To further characterize the use of baculovirus as a mammalian gene delivery system, we examined the status of tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4949ad171eedb8f9725823501c1473
https://pubmed.ncbi.nlm.nih.gov/11134303
https://pubmed.ncbi.nlm.nih.gov/11134303
Autor:
D M, Ignar, J L, Andrews, S M, Witherspoon, J D, Leray, W C, Clay, K, Kilpatrick, J, Onori, T, Kost, D L, Emerson
Publikováno v:
Clinicalexperimental metastasis. 16(1)
Tumor establishment and metastasis are dependent on extracellular matrix proteolysis, tumor cell migration, and angiogenesis. Urokinase plasminogen activator (uPA) and its receptor are essential mediators of these processes. The purpose of this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1088d282af4e3bc460f3bc138e77448c
https://pubmed.ncbi.nlm.nih.gov/9502073
https://pubmed.ncbi.nlm.nih.gov/9502073
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 153(2)
In these studies, we show that NF-kappa B induces transcription from the human pro-IL-1 beta (IL-1 beta) gene. A recombinant plasmid pIL-1(-4000)-CAT, containing 4 kb of the IL-1 beta gene upstream regulatory sequence was transactivated by the p65 su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b449ed46f0d004b3da549b6e628a756d
https://pubmed.ncbi.nlm.nih.gov/8021507
https://pubmed.ncbi.nlm.nih.gov/8021507