Zobrazeno 1 - 10
of 25
pro vyhledávání: '"W C, Mobley"'
Phase transition temperature reduction and glass formation in dehydroprotected lyophilized liposomes
Autor:
Hans Schreier, W. C. Mobley
Publikováno v:
Journal of Controlled Release. 31:73-87
Two prevailing theories for dry membrane preservation are the water replacement hypothesis and glass formation. A manifestation of the water replacement hypothesis is the ability of sugars to depress dry membrane main phase transition temperatures (
Publikováno v:
Neuron. 32(5)
The target-derived neurotrophic factor "nerve growth factor" (NGF) signals through TrkA to promote the survival, differentiation, and maintenance of neurons. How the NGF signal in axon terminals is conveyed to the cell body is unknown. The "signaling
Autor:
J D, Cooper, W C, Mobley
Publikováno v:
Advances in genetics. 45
Autor:
H M, Mitchison, D J, Bernard, N D, Greene, J D, Cooper, M A, Junaid, R K, Pullarkat, N, de Vos, M H, Breuning, J W, Owens, W C, Mobley, R M, Gardiner, B D, Lake, P E, Taschner, R L, Nussbaum
Publikováno v:
Neurobiology of disease. 6(5)
Batten disease, a degenerative neurological disorder with juvenile onset, is the most common form of the neuronal ceroid lipofuscinoses. Mutations in the CLN3 gene cause Batten disease. To facilitate studies of Batten disease pathogenesis and treatme
Autor:
W C, Mobley
Publikováno v:
Pharmaceutical research. 15(1)
A signaling endosome hypothesis to explain NGF actions: potential implications for neurodegeneration
Publikováno v:
Cold Spring Harbor symposia on quantitative biology. 61
Publikováno v:
Cold Spring Harbor symposia on quantitative biology. 61
A long trail of evidence indicates that the formation of PrPSc or its accumulation causes the neuronal dysfunction and clinical features of prion diseases. The results of our current line of studies argue that the main neuropathological and clinical
Autor:
D M, Holtzman, J, Kilbridge, Y, Li, E T, Cunningham, N J, Lenn, D O, Clary, L F, Reichardt, W C, Mobley
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 15(2)
NGF acts as a neurotrophic factor by binding and activating its receptor on certain neuronal populations in the CNS and PNS. TrkA is a receptor for NGF. Recent findings in vitro indicate that this NGF-activated receptor tyrosine kinase transduces the
Autor:
D M, Holtzman, J, Kilbridge, K S, Chen, J, Rabin, R, Luche, E, Carlson, C J, Epstein, W C, Mobley
Publikováno v:
Progress in clinical and biological research. 393
Autor:
D M, Holtzman, W C, Mobley
Publikováno v:
The Western journal of medicine. 161(3)
Discovered only 40 years ago, nerve growth factor is the prototypic neurotrophic factor. By binding to specific receptors on certain neurons in the peripheral nervous system and brain, nerve growth factor acts to enhance their survival, differentiati