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Regioselective O-demethylation of scoparone (6,7-dimethoxycoumarin) to assess cytochrome P450 activities in vitro in rat. Effects of gonadal steroids and the involvement of constitutive P450 enzymes

Autor: Renger F. Witkamp, Sandra M. Nijmeijer, A. S. J. P. A. M. van Miert, A. W. Rozema, Jan Noordhoek, W. C. Mennes

Publikováno v: Xenobiotica. 23:401-410

1. In the rat, scoparone (6,7-dimethoxycoumarin) is regioselectively O-demethylated in vitro by the hepatic cytochrome P450 (P450) system, yielding isoscopoletin and scopoletin. 2. Scoparone has been proposed as an indicator substrate for the assessm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8867cb21c68aef701e230dfcec7163
https://doi.org/10.3109/00498259309057028

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Effects of the peroxisome proliferator mono(2-ethylhexyl)phthalate in primary hepatocyte cultures derived from rat, guinea pig, rabbit and monkey. Relationship between interspecies differences in biotransformation and peroxisome proliferating potencies

Autor: H A, Dirven, P H, van den Broek, M C, Peeters, J G, Peters, W C, Mennes, B J, Blaauboer, J, Noordhoek, F J, Jongeneelen

Publikováno v: Biochemical pharmacology. 45(12)

Primary hepatocyte cultures derived from rat, rabbit, guinea pig and monkey have been treated in vitro with metabolites of di(2-ethylhexyl)phthalate, i.e. mono(2-ethylhexyl)phthalate (MEHP), mono(5-carboxy-2-ethylpentyl)phthalate (metabolite V) and m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2aa782384b97336a2b2c8051f9b23c45
https://pubmed.ncbi.nlm.nih.gov/8328980

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