Zobrazeno 1 - 10
of 22
pro vyhledávání: '"W C, Kouns"'
Publikováno v:
Thrombosis Research. 88:109-125
Inhibition of aggregation by Ro 44-9883, a potent and selective non-peptide GPIIb/IIIa antagonist, resulted in inhibition of serotonin secretion induced by weak agonists such as ADP or low doses of either thrombin receptor agonist peptide (TRAP) or c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110a6b57ce3817e2fc9f2c95993f694c
https://doi.org/10.1016/s0049-3848(97)00223-5
https://doi.org/10.1016/s0049-3848(97)00223-5
Autor:
Tatjana V. Byzova, S. G. Khaspekova, Oleg Yu. Tikhomirov, Michael C. Berndt, W. C. Kouns, Beat Steiner, Mazurov Av
Publikováno v:
FEBS Letters. 391:84-88
Platelet glycoprotein (GP) IIb-IIIa complex (alpha IIb beta 3-integrin) changes its conformation upon platelet activation that results in binding of RGD-containing ligands and expression of ligand-induced binding site (LIBS) neoepitopes. Anti-GIIb-II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a353386baeae19d4b8dd442c23e2e8
https://doi.org/10.1016/0014-5793(96)00709-0
https://doi.org/10.1016/0014-5793(96)00709-0
Autor:
Josef Hübscher, W. C. Kouns, Beat Steiner, Jurg Hurst, Daniel Schlatter, Richard Barner, Walter Huber
Publikováno v:
European Journal of Biochemistry. 227:647-656
The binding reaction between purified human platelet glycoprotein IIb-IIIa and fibrinogen was investigated by real-time measurements using the surface-plasmon-resonance sensor technology. In these experiments, either glycoprotein IIb-IIIa or fibrinog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d146675ea662828c2e76371e770f9e
https://doi.org/10.1111/j.1432-1033.1995.tb20184.x
https://doi.org/10.1111/j.1432-1033.1995.tb20184.x
Autor:
François Lanza, Lisa K. Jennings, Beat Steiner, Sylvie Moog, W. C. Kouns, Joseph Jutzi, Thomas J. Kunicki, Jean-Pierre Cazenave
Publikováno v:
Blood. 84:1108-1115
One proposed ligand binding site on platelet integrin alpha IIb beta 3 is the region of the beta 3 subunit encompassing amino acids 211–221. However, we recently showed that synthetic peptides corresponding to amino acids 211–221 inhibit fibrinog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b6d176d8ae7796248811f343125250b
https://doi.org/10.1182/blood.v84.4.1108.1108
https://doi.org/10.1182/blood.v84.4.1108.1108
Publikováno v:
Journal of Biological Chemistry. 269:8754-8761
Integrin alpha IIb-beta 3 binds fibrinogen via the recognition sequence Arg-Gly-Asp-Ser (RGDS). We have used the baculovirus/insect cell expression system to study the structural requirements for the formation of a functionally active fragment of alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80099f0428105edb28abf3c26d6bbb30
https://doi.org/10.1016/s0021-9258(17)37033-3
https://doi.org/10.1016/s0021-9258(17)37033-3
Publikováno v:
Journal of Biological Chemistry. 268:6870-6873
Peptides derived from a sequence within the loop structure of human platelet glycoprotein (GP) IIIa (integrin beta 3) were previously shown to inhibit fibrinogen binding to purified GPIIb-IIIa. In this study a series of peptides based on the GPIIIa s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c558000a93aa7080b0cfe36b39a976b4
https://doi.org/10.1016/s0021-9258(18)53119-7
https://doi.org/10.1016/s0021-9258(18)53119-7
Autor:
Paul Hadvary, Beat Steiner, Hans R. Baumgartner, D Kirchhofer, G Pfenninger, LK Jennings, A Edenhofer, Thomas Weller, W. C. Kouns
Publikováno v:
Blood. 80:2539-2547
Platelet glycoprotein (GP) IIb-IIIa inhibitors may become useful antithrombotic agents. Ro 4–5054 is a low molecular weight, noncyclic, peptidomimetic inhibitor that is three orders of magnitude more potent than RGDS in inhibiting fibrinogen bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad603a7760c464db287604f72b147b6
https://doi.org/10.1182/blood.v80.10.2539.bloodjournal80102539
https://doi.org/10.1182/blood.v80.10.2539.bloodjournal80102539
Publikováno v:
Journal of Biological Chemistry. 267:18844-18851
This study characterized conformational states of platelet glycoprotein IIb-IIIa (GPIIb-IIIa) and regions of the molecule required for fibrinogen binding. Platelet lysates were passed sequentially over concanavalin A and aminoethylglycine (Aeg)RGDS a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2a8e7bd8de01978bb4a34df063e06a6
https://doi.org/10.1016/s0021-9258(19)37038-3
https://doi.org/10.1016/s0021-9258(19)37038-3
Autor:
Lisa K. Jennings, W C Kouns, PJ Newman, CD Wall, C F Fox, Jerome M. Seyer, AA Miller, KJ Puckett
Publikováno v:
Blood. 78:3215-3223
Glycoprotein (GP) IIb-IIIa serves as the platelet fibrinogen receptor. Studies of the tertiary structure of GPIIIa have shown that the protein has a large loop structure of at least 325 amino acids in length. To further characterize this loop structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4bb39c678652857f4ab538a9043a492
https://doi.org/10.1182/blood.v78.12.3215.bloodjournal78123215
https://doi.org/10.1182/blood.v78.12.3215.bloodjournal78123215
Autor:
W C, Kouns, P J, Newman, K J, Puckett, A A, Miller, C D, Wall, C F, Fox, J M, Seyer, L K, Jennings
Publikováno v:
Blood. 78:3215-3223
Glycoprotein (GP) IIb-IIIa serves as the platelet fibrinogen receptor. Studies of the tertiary structure of GPIIIa have shown that the protein has a large loop structure of at least 325 amino acids in length. To further characterize this loop structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e10f6c53e6b1a74888c0f76c290bf6
https://doi.org/10.1182/blood.v78.12.3215.3215
https://doi.org/10.1182/blood.v78.12.3215.3215