Zobrazeno 1 - 10 of 32 pro vyhledávání: '"W C, Kenney"'
1
Pharmacokinetic, pharmacodynamic, and pharmacotoxic profiles of recombinant- methionyl human interleukin-2 [alanine- 125] (r-metHuIL-2[ala-125]) following intravenous and subcutaneous administration in rats
Autor: L. C. K. Wong, B. J. Payne, J. D. Young, L. E. Sendelbach, W. C. Kenney, D. P. Bell, L. Langlois, C. P. Lebel
Publikováno v: Human & Experimental Toxicology. 14:909-915
Comparative pharmacotoxicity studies in rats were per formed to evaluate the response to r-metHuIL-2[ala-125] following 2 or 4 weeks of daily intravenous or sub cutaneous administration, as well as to evaluate pharmacokinetic and pharmacodynamic resp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6296f74492c4a1cace9f6a5299a87a48
https://doi.org/10.1177/096032719501401109
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2
Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds
Autor: J Tseng, W C Kenney, J Bready, Martin C. Robson, Glenn F. Pierce, P Reid, D. Chang, Ross Rudolph, John E. Tarpley, J. S. Vande Berg
Publikováno v: Journal of Clinical Investigation. 96:1336-1350
Some human chronic dermal wounds treated with recombinant platelet-derived growth factor-BB (rPDGF-BB) show increased healing coupled with fibroblast activation and granulation tissue formation. To determine whether endogenous PDGF is associated with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fde5d43e89cb16c3508565297c91104
https://doi.org/10.1172/jci118169
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3
Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor
Autor: Glenn F. Pierce, Hsu Eric W, D Yanagihara, Dimitry M. Danilenko, K Klopchin, W C Kenney, Morris Charles F
Publikováno v: The Journal of Experimental Medicine
Keratinocyte growth factor (KGF), a recently discovered 18.9 kD member of the fibroblast growth factor family has been shown to selectively induce keratinocyte proliferation and differentiation in tissue culture. To explore its potential stimulating
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabbf194a4e76f87791dfce3c0cbe2c6
https://doi.org/10.1084/jem.179.3.831
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4
Aggregation pathway of recombinant human keratinocyte growth factor and its stabilization
Autor: B L, Chen, T, Arakawa, C F, Morris, W C, Kenney, C M, Wells, C G, Pitt
Publikováno v: Pharmaceutical research. 11(11)
Recombinant human keratinocyte growth factor (rhKGF) is prone to aggregation at elevated temperatures. Its aggregation pathway is proposed to proceed initially with a conformational change which perhaps results from repulsion between positively charg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f797b46472feb5c392ea4ffe122fa5b6
https://pubmed.ncbi.nlm.nih.gov/7870675
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5
Formation of mitogenically active PDGF-B dimer does not require interchain disulfide bonds
Autor: W C, Kenney, M, Haniu, A C, Herman, T, Arakawa, V J, Costigan, J, Lary, D A, Yphantis, A R, Thomason
Publikováno v: The Journal of biological chemistry. 269(16)
Platelet-derived growth factor (PDGF), a major mitogen for mesenchymal cells, is a disulfide-bonded dimer of two subunit polypeptides named A and B. All of the three possible dimeric forms, i.e. AA, BB, and AB, exist in nature. The dimeric structure
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff75dd674e631a70b7d781cc2c89ae3b
https://pubmed.ncbi.nlm.nih.gov/8163539
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6
The reaction of N-ethylmaleimide at the active site of succinate dehydrogenase
Autor: W C Kenney
Publikováno v: Journal of Biological Chemistry. 250:3089-3094
Since 1938 mammalian succinate dehydrogenase has been thought to contain thiol groups at the active site. This hypothesis was questioned recently, because irreversible inhibition by bromopyruvate and N-ethylmaleimide appeared not to satisfy the requi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::315de5aa3a60e2e9dde6c79299a73c83
https://doi.org/10.1016/s0021-9258(19)41598-6
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8
Localization of the substrate and oxalacetate binding site of succinate dehydrogenase
Autor: Thomas P. Singer, P C Mowery, R. Seng, W C Kenney
Publikováno v: Journal of Biological Chemistry. 251:2369-2373
Succinate dehydrogenase is composed of two subunits, one of molecular weight 70,000, containing FAD in covalent linkage to a histidyl residue of the polypeptide chain, the other subunit of molecular weight 30,000. The fact that substrate, substrate a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4804b51e141af6b3dd60855bbe9cc1a3
https://doi.org/10.1016/s0021-9258(17)33596-2
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9
A novel type of covalently bound coenzyme in trimethylamine dehydrogenase
Autor: Thomas P. Singer, W C Kenney, D J Steenkamp
Publikováno v: Journal of Biological Chemistry. 253:2812-2817
Bacterial trimethylamine dehydrogenase contains a covalently bound yellow coenzyme, the properties of which distinguish it from all known riboflavin, pyridoxine, and pteridine derivatives. A pure dodecapeptide containing the covalently linked coenzym
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::778696a88016efa9e7fe900cd514611a
https://doi.org/10.1016/s0021-9258(17)40895-7
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