Zobrazeno 1 - 10
of 36
pro vyhledávání: '"W Brad, Hubbard"'
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-11 (2024)
Abstract Background Neurovascular deficits and blood-brain barrier (BBB) dysfunction are major hallmarks of brain trauma and neurodegenerative diseases. Oxidative stress is a prominent contributor to neurovascular unit (NVU) dysfunction and can propa
Externí odkaz:
https://doaj.org/article/8d19da83d2eb481bbbae4c4b44e9816e
Autor:
Olivia J. Kalimon, Hemendra J. Vekaria, Gopal V. Velmurugan, W. Brad Hubbard, Patrick G. Sullivan
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 627-642 (2023)
Traumatic brain injury (TBI) is caused by an impact or penetrating injury to the head resulting in abnormal brain function. Mitochondrial dysfunction is an important hallmark of TBI and has been thoroughly studied in male rodent models of brain injur
Externí odkaz:
https://doaj.org/article/546dfda817774a33880b1afc465a2a50
Autor:
Olivia J. Kalimon, Hemendra J. Vekaria, Paresh Prajapati, Sydney L. Short, W. Brad Hubbard, Patrick G. Sullivan
Publikováno v:
Life, Vol 14, Iss 8, p 961 (2024)
Current literature finds females have improved outcomes over their male counterparts after severe traumatic brain injury (TBI), while the opposite seems to be true for mild TBI. This begs the question as to what may be driving these sex differences a
Externí odkaz:
https://doaj.org/article/86fa9c68ca5d49339128bb6c6eece016
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract Low-level blast exposure can result in neurological impairment for military personnel. Currently, there is a lack of experimental data using sex as a biological variable in neurovascular outcomes following blast exposure. To model mild blast
Externí odkaz:
https://doaj.org/article/2ca1afccba564370b3fcad45d3e5f777
Autor:
Gopal V. Velmurugan, W. Brad Hubbard, Paresh Prajapati, Hemendra J. Vekaria, Samir P. Patel, Alexander G. Rabchevsky, Patrick G. Sullivan
Publikováno v:
Cells, Vol 12, Iss 10, p 1445 (2023)
The brain undergoes oxidative stress and mitochondrial dysfunction following physiological insults such as Traumatic brain injury (TBI), ischemia-reperfusion, and stroke. Pharmacotherapeutics targeting mitochondria (mitoceuticals) against oxidative s
Externí odkaz:
https://doaj.org/article/9f94aa251cc2430e9f7a742e04917022
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 4, Pp n/a-n/a (2022)
Abstract Background Traumatic brain injury (TBI) results in neurovascular damage that initiates intrinsic mechanisms of hypercoagulation, which can contribute to the development of life‐threatening complications, such as coagulopathy and delayed th
Externí odkaz:
https://doaj.org/article/d545223b28be42b1a85f87eb36479cd0
Autor:
Hemendra J. Vekaria, W. Brad Hubbard, Natalie E. Scholpa, Malinda L. Spry, Jennifer L. Gooch, Sydney J. Prince, Rick G. Schnellmann, Patrick G. Sullivan
Publikováno v:
Neurobiology of Disease, Vol 140, Iss , Pp 104866- (2020)
Traumatic brain injury (TBI) leads to acute necrosis at the site of injury followed by a sequence of secondary events lasting from hours to weeks and often years. Targeting mitochondrial impairment following TBI has shown improvements in brain mitoch
Externí odkaz:
https://doaj.org/article/d6b090ab489f43e39ac740c82e4dd014
Autor:
Bruce A Berkowitz, Hailey K Olds, Collin Richards, Joydip Joy, Tilman Rosales, Robert H Podolsky, Karen Lins Childers, W Brad Hubbard, Patrick G Sullivan, Shasha Gao, Yichao Li, Haohua Qian, Robin Roberts
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226840 (2020)
PurposeTo test the hypothesis that imaging biomarkers are useful for evaluating in vivo rod photoreceptor cell responses to a mitochondrial protonophore.MethodsIntraperitoneal injections of either the mitochondrial uncoupler 2,4 dinitrophenol (DNP) o
Externí odkaz:
https://doaj.org/article/d2e55ae9cde34035a82fb7d7686e1036
Autor:
W Brad Hubbard, Hemendra J Vekaria, Olivia J Kalimon, Malinda L Spry, Emily P Brown, Todd J Kilbaugh, Patrick G Sullivan
Publikováno v:
Brain Communications. 5
Pioglitazone interacts through the mitochondrial protein mitoNEET to improve brain bioenergetics following traumatic brain injury. To provide broader evidence regarding the therapeutic effects of pioglitazone after traumatic brain injury, the current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8863067bbd2e28d92067881fe5b85b6b
https://doi.org/10.1093/braincomms/fcad032
https://doi.org/10.1093/braincomms/fcad032
Autor:
W Brad Hubbard, Malinda L Spry, Jennifer L Gooch, Amber L Cloud, Hemendra J Vekaria, Shawn Burden, David K Powell, Bruce A Berkowitz, Werner J Geldenhuys, Neil G Harris, Patrick G Sullivan
Publikováno v:
Brain
Pioglitazone, an FDA-approved compound, has been shown to target the novel mitochondrial protein mitoNEET and produce short-term neuroprotection and functional benefits following traumatic brain injury. To expand on these findings, we now investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb74f9dfdf9b4d5f6756fa074c50c46
http://europepmc.org/articles/PMC8719838
http://europepmc.org/articles/PMC8719838