Optimization of tumor-treating field therapy for triple-negative breast cancer cells in vitro via frequency modulation

Autor: Austin R. Smothers, Jason R. Henderson, John J. O’Connell, Jonathan M. Stenbeck, Delphine Dean, Brian W. Booth

Publikováno v: Cancer Cell International, Vol 23, Iss 1, Pp 1-8 (2023)

Abstract Purpose Currently, tumor-treating field (TTField) therapy utilizes a single “optimal” frequency of electric fields to achieve maximal cell death in a targeted population of cells. However, because of differences in cell size, shape, and

Externí odkaz: https://doaj.org/article/5087cb2efb614be39af589b60e32a672

Comparative gene co-expression networks show enrichment of brassinosteroid and vitamin B processes in a seagrass under simulated ocean warming and extreme climatic events

Autor: Mitchell W. Booth, Elizabeth A. Sinclair, Elisabeth Maria U. Jung, Rachel Austin, Philipp E. Bayer, Siegfried L. Krauss, Martin F. Breed, Gary A. Kendrick

Publikováno v: Frontiers in Plant Science, Vol 15 (2024)

IntroductionOcean warming combined with extreme climatic events, such as marine heatwaves and flash flooding events, threaten seagrasses globally. How seagrasses cope with these challenges is uncertain, particularly for range-edge populations of spec

Externí odkaz: https://doaj.org/article/9c4e38b82667413ca08c3da4bd81b75f

Efficacy and selectivity of tumor-treating field therapy for triple-negative breast cancer cells via in-house delivery device

Autor: Austin R. Smothers, Jason R. Henderson, John J. O’Connell, Jonathan M. Stenbeck, Delphine Dean, Tyler G. Harvey, Brian W. Booth

Publikováno v: Discover Oncology, Vol 14, Iss 1, Pp 1-10 (2023)

Abstract Purpose Triple-negative breast cancer continues to be one of the leading causes of death in women, making up 7% of all cancer deaths. Tumor-treating electric fields are low-energy, low-frequency oscillating electric fields that induce an ant

Externí odkaz: https://doaj.org/article/32948a8b75f545ed913b0849cad2e179

Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV

Autor: Rachel K.Y. Hung, Elizabeth Binns-Roemer, John W. Booth, Rachel Hilton, Julie Fox, Fiona Burns, Mark Harber, Andrew Ustianowski, Lisa Hamzah, James E. Burns, Amanda Clarke, David A. Price, Stephen Kegg, Denis Onyango, Beatriz Santana-Suarez, Lucy Campbell, Kate Bramham, Claire C. Sharpe, Caroline A. Sabin, Cheryl A. Winkler, Frank A. Post, John Booth, Anele Waters, James Hand, Chris Clarke, Sarah Murphy, Maurice Murphy, Marion Campbell, Celia Richardson, Alyson Knott, Gemma Weir, Rebecca Cleig, Helena Soviarova, Lisa Barbour, Tanya Adams, Vicky Kennard, Vittorio Trevitt, Rachael Jones, Jeremy Levy, Alexandra Schoolmeester, Serah Duro, May Rabuya, Deborah Jordan, Teresa Solano, Hiromi Uzu, Karen Williams, Julianne Lwanga, Linda Ekaette Reid-Amoruso, Hannah Gamlen, Robert J. Stocker, Fiona Ryan, Karina Mahiouz, Tess Cheetham, Claire Williams, Achyuta Nori, Caroline Thomas, Sivaraj Venkateshwaran, Jessica Doctor, Andrea Berlanga, Frank Post, Leigh McQueen, Priya Bhagwandin, Bee Barbini, Emily Wandolo, Tim Appleby, Lois Driver, Sophy Parr, Hongbo Deng, Julie Barber, Andrew Crowe, Chris Taylor, Mary Poulton, Vida Boateng, Marie-Pierre Klein, Caitlin O’Brien, Samuel Ohene-Adomako, Christian Buckingham, Daniel Trotman, Killian Quinn, Kate Flanagan, Verity Sullivan, Holly Middleditch, Itty Samuel, Elizabeth Hamlyn, Candice McDonald, Ana Canoso, Emeka Agbasi, Maria Liskova, Sarah Barber, Amanda Samarawickrama, Zoe Ottaway, Claire Norcross, Amelia Oliveira, Jane Minton, Gary Lamont, Ruby Cross, Gaushiya Saiyad, Shadia Ahmed, Rebecca Ashworth, Nicola Window, J. Murira, Khine Phyu, Gabriella Lindergard, Jonathan Shaw, Sarah Holland, Claire Fox, Jan Flaherty, Margaret-Anne Bevan, Valerie George, David Chadwick, Marie Branch, Pauline Lambert, Adele Craggs, Sarah Pett, Hinal Lukha, Nina Vora, Marzia Fiorino, Maria Muller Nunez, Deirdre Sally, Erica Pool, Rebecca Matthews, David Ashley Price, Tara Stothard, Bijal Patel, Ian McVittie, Ciara Kennedy, Uli Shwab, Brendan Payne, Sarah Duncan, Jill Dixon, Mathias Schmid, Adam Evans, Christopher Duncan, Ewan Hunter, Yusri Taha, Natasha Astill, Cheryl Winkler, Victor David, Jonathan Ainsworth, Rachel Vincent, Chloe Saad, Sarah Skinner, Hocine Azzoug, Judith Russell, Tarik Moussaoui, Emily Mabonga, Donna Ward, J. Francoise, W. Larbi, Sue Mitchell, A. Manning, V. Russell, Nnenna Ngwu, Jonathan Edwards, Nargis Hemat, Tom Fernandez, Filippo Ferro, Jorge Ferreira, Alice Nightingale, Tasha Oakes-Monger, Darwin Matila, Pedro Nogueira, Victoria Mutagwanya, Catherine Cosgrove, Catherine Emily Isitt, Helen Webb, Joyce Popoola, Kate Korley, Mark Mencias, Patricia Ribeiro, Rajeshwar Ramkhelawn, Sandra Oliva Lara, Sara Sajijad, Alan Winston, Amber Shaw, Claire Petersen, Kyle Ring, Melanie Rosenvinge, Thembi Moyo, Faith Odong, Katherine Gantert, Tina Ibe, Caroline Sabin, Teresa Hill

Publikováno v: Kidney International Reports, Vol 7, Iss 3, Pp 465-473 (2022)

Introduction: Sickle cell trait (SCT) has been associated with chronic kidney disease (CKD) in African Americans, although evidence for its impact in Africans and people with HIV is currently lacking. We conducted a cross-sectional study investigatin

Externí odkaz: https://doaj.org/article/4cf2d54ad87e424fb52a38c5375589cf

An integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila

Autor: James B. Brown, Sasha A. Langley, Antoine M. Snijders, Kenneth H. Wan, Siti Nur Sarah Morris, Benjamin W. Booth, William W. Fisher, Ann S. Hammonds, Soo Park, Richard Weiszmann, Charles Yu, Jennifer A. Kirwan, Ralf J. M. Weber, Mark R. Viant, Jian-Hua Mao, Susan E. Celniker

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)

Brown et al. apply integrated omics and phenotypic screening to assess the role of the gut microbiome in modulating host resilience in Drosophila melanogaster. They find that Acetobacter tropicalis in gnotobiotic animals, is sufficient to rescue incr

Externí odkaz: https://doaj.org/article/c3ab3d12ed36490693a2a628de744736