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Autophagy, cell death and sustained senescence arrest in B16/F10 melanoma cells and HCT-116 colon carcinoma cells in response to the novel microtubule poison, JG-03-14

Autor: Jorge A. Almenara, Xu Di, David A. Gewirtz, Moureq R. Alotaibi, Jonathan W. Biggers, Ronetta Brown, Kimber L. White, Scott C. Henderson, Sean M. Emery, John T. Gupton, Tuyen Nguyen

Publikováno v: Cancer chemotherapy and pharmacology. 71(2)

Previous studies have shown that the novel microtubule poison, JG-03-14, which binds to the colchicine binding site of tubulin, has the capacity to kill breast tumor cells primarily through the promotion of autophagy. The current work was designed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5ea00315a0a8b93c7fae4f02b72f77
https://pubmed.ncbi.nlm.nih.gov/23178952

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Counterregulation During Hypoglycemia Is Directed by Widespread Brain Regions

Autor: Doss W. Neal, Sharon R Myers, Cynthia C. Connolly, Jonathan B. Jaspan, R. T. Frizzell, Alan D. Cherrington, Stephen N. Davis, D. W. Biggers, E. M. Jones

Publikováno v: Diabetes. 42:1253-1261

Previous studies have demonstrated the importance of the brain in directing counterregulation during insulin-induced hypoglycemia in dogs. The capability of selective carotid or vertebrobasilar hypoglycemia in triggering counterregulation was assesse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042e93d94c24178a4b19a4f4ae7d667f
https://doi.org/10.2337/diab.42.9.1253

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Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo

Autor: Doss W. Neal, Sharon R Myers, D. W. Biggers, Alan D. Cherrington

Although the importance of the hepatic glucose load in the regulation of liver glucose uptake has been clearly demonstrated in in vitro systems, the relationship between the hepatic glucose load and hepatic glucose uptake has yet to be defined in viv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc83677bb8d07b7c5de2a373d24a15ee
https://europepmc.org/articles/PMC296016/

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Hypoglycemia, Gluconeogenesis and the Brain

Autor: D. W. Biggers, R. T. Frizzell, Alan D. Cherrington, Cynthia C. Connolly

Publikováno v: Fuel Homeostasis and the Nervous System ISBN: 9781468459333

The purpose of this chapter is to review the role which gluconeo- genesis plays in the response to insulin-induced hypoglycemia and to assess the influence of the brain in driving that response. The chapter is divided into three parts: the response o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7d845243ded61407a667e5aad494d53
https://doi.org/10.1007/978-1-4684-5931-9_15

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Role of Gluconeogenesis in Sustaining Glucose Production During Hypoglycemia Caused by Continuous Insulin Infusion in Conscious Dogs

Autor: Alan D. Cherrington, Phillip E. Williams, Donald R. Green, G K Hendrick, Ralph W. Stevenson, R. T. Frizzell, R K Carr, D P Donahue, D. B. Lacy, D. W. Biggers

Publikováno v: Diabetes. 37:749-759

The roles of glycogenolysis and gluconeogenesis in sustaining glucose production during insulin-induced hypoglycemia were assessed in overnight-fasted conscious dogs. Insulin was infused intraportally for 3 h at 5 mU.kg-1.min-1 in five animals, and g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd61bb02022385ede10c5962d57369e
https://doi.org/10.2337/diab.37.6.749

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