Zobrazeno 1 - 10
of 10
pro vyhledávání: '"W B de Lau"'
Autor:
M Kamoun, J S Woods, N Sano, H Makni, R Smith, W B de Lau, A van Oers, D Wotton, M J Owen, Y Hashimoto, H C Clevers
Publikováno v:
The Journal of Immunology. 155:3929-3937
Thirty CD2- J32 stable clones, derived by mutagenesis and subsequent immunoselection with anti-CD2 Ab, were used to study the regulation of CD2 and TCR gene expression. Analysis of RNA expression revealed that the loss of surface expression of CD2 wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49fc9646d25a30450ead74aa5553f5b2
https://doi.org/10.4049/jimmunol.155.8.3929
https://doi.org/10.4049/jimmunol.155.8.3929
Autor:
I A, Haagen, A J, Geerars, W B, de Lau, M R, Clark, R J, van de Griend, B J, Bast, B C, de Gast
Publikováno v:
Blood. 84:556-563
To develop an effective tumor immunotherapy for B-lineage non-Hodgkin's lymphoma (NHL) and acute lymphoblastic leukemia (ALL), a bispecific monoclonal antibody (BsAb) has been generated with the first specificity for the CD3 epsilon-chain and the sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a76c071586014083b9acf7f0681b2fa
https://doi.org/10.1182/blood.v84.2.556.bloodjournal842556
https://doi.org/10.1182/blood.v84.2.556.bloodjournal842556
Publikováno v:
The Journal of Immunology. 150:4911-4919
Cells regulate the specificity of the carbohydrate chains on their membrane-bound glycoconjugates by differential expression of glycosyltransferases. In lymphocytes, beta-galactoside alpha 2,6-sialyltransferase is reportedly involved in the generatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acc722317941b794f2f066ecbe4bb742
https://doi.org/10.4049/jimmunol.150.11.4911
https://doi.org/10.4049/jimmunol.150.11.4911
Autor:
W B De Lau, S E Boom, K Heije, A W Griffioen, E Braakman, R L Bolhuis, W J Tax, H Clevers, B J Bast
Publikováno v:
The Journal of Immunology. 149:1840-1846
During physiologic activation of mature CD8+ T cells, TCR and CD8 bind to the same Ag-complexed MHC class I molecule. Thereby, close proximity is induced between CD8 and the TCR/CD3 complex. During this engagement, CD8 may deliver TCR-independent sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8b3f511094371f2841f8599dddb253
https://doi.org/10.4049/jimmunol.149.6.1840
https://doi.org/10.4049/jimmunol.149.6.1840
Publikováno v:
The Journal of Immunology. 146:906-914
Bispecific mAb contain two Ag-combining sites each composed of a different combination of H and L chains. The resulting ability to react with and cross-link two different Ag makes these molecules a novel tool for application in biology and medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73cc8ba27cdbeaf4025d6544e8fe2fb3
https://doi.org/10.4049/jimmunol.146.3.906
https://doi.org/10.4049/jimmunol.146.3.906
Autor:
M, Kamoun, J S, Woods, N, Sano, H, Makni, R, Smith, W B, de Lau, A, van Oers, D, Wotton, M J, Owen, Y, Hashimoto, H C, Clevers
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 155(8)
Thirty CD2- J32 stable clones, derived by mutagenesis and subsequent immunoselection with anti-CD2 Ab, were used to study the regulation of CD2 and TCR gene expression. Analysis of RNA expression revealed that the loss of surface expression of CD2 wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25852e06885038bbdc14de35d04452a5
https://pubmed.ncbi.nlm.nih.gov/7561100
https://pubmed.ncbi.nlm.nih.gov/7561100
Publikováno v:
Blood. 85(11)
To evaluate the potency by which human T cells are targeted and activated by bispecific monoclonal antibodies (BsAbs) to lyse tumor cells, a clonogenic assay was developed. The efficacy of a CD3 x CD19 BsAb binding to both the CD3 T-cell antigen and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c46171bcf928f41cb6db17879543480
https://pubmed.ncbi.nlm.nih.gov/7538821
https://pubmed.ncbi.nlm.nih.gov/7538821
Publikováno v:
Therapeutic immunology. 1(5)
Two bispecific monoclonal antibodies (BsAb), differing in H chain isotype combination, were made for treatment of B-cell leukaemia/lymphoma; QAI-2, CD3-mouse-IgG1 x CD19-mouse-IgG2a and QAI-3, CD3-mouse-IgG1 x CD19-mouse-IgG2b. Both purified BsAb pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e20fcff565ee323f0739f744fb3315db
https://pubmed.ncbi.nlm.nih.gov/7584502
https://pubmed.ncbi.nlm.nih.gov/7584502
Autor:
W B, De Lau, S E, Boom, K, Heije, A W, Griffioen, E, Braakman, R L, Bolhuis, W J, Tax, H, Clevers, B J, Bast
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 149(6)
During physiologic activation of mature CD8+ T cells, TCR and CD8 bind to the same Ag-complexed MHC class I molecule. Thereby, close proximity is induced between CD8 and the TCR/CD3 complex. During this engagement, CD8 may deliver TCR-independent sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::621f3fe2cde1fc3922dea2a4dc91b8a0
https://pubmed.ncbi.nlm.nih.gov/1387662
https://pubmed.ncbi.nlm.nih.gov/1387662
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 146(3)
Bispecific mAb contain two Ag-combining sites each composed of a different combination of H and L chains. The resulting ability to react with and cross-link two different Ag makes these molecules a novel tool for application in biology and medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b23b1ecb47dc4c7bbedea063dfef355f
https://pubmed.ncbi.nlm.nih.gov/1899099
https://pubmed.ncbi.nlm.nih.gov/1899099