Výsledky vyhledávání - "W B, van den Berg"

Anti-cytokine therapy in chronic destructive arthritis

Autor: W B, van den Berg

Publikováno v: Arthritis Research

Tumor necrosis factor (TNF) and interleukin-1 (IL-1) are considered to be master cytokines in chronic, destructive arthritis. Therapeutic approaches in rheumatoid arthritis (RA) patients have so far focused mainly on TNF, which is a major inflammator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d1e86ae6f0dd1cab7240aca63f2f2586
http://europepmc.org/articles/PMC128880

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Gene expression analysis of murine and human osteoarthritis synovium reveals elevation of transforming growth factor β-responsive genes in osteoarthritis-related fibrosis

Autor: D F G, Remst, A B, Blom, E L, Vitters, R A, Bank, W B, van den Berg, E N, Blaney Davidson, P M, van der Kraan

Publikováno v: Arthritisrheumatology (Hoboken, N.J.). 66(3)

Synovial fibrosis is a major contributor to joint stiffness in osteoarthritis (OA). Transforming growth factor β (TGFβ), which is elevated in OA, plays a key role in the onset and persistence of synovial fibrosis. However, blocking of TGFβ in OA a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::274f04e677984a97abd6ce0586abdf7f
https://pubmed.ncbi.nlm.nih.gov/24574225

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Detection of intestinal flora-derived bacterial antigen complexes in splenic macrophages of rats

Autor: I. S. Klasen, Marie-José Melief, G M Bahr, H. de Visser, W. B. Van Den Berg, C G Van Helden-Meeuwsen, M Y Gerrits-Boeye, J. Kool, L. M. C. Van Lieshout, J. G. H. Ruseler-Van Embden

Publikováno v: Journal of Histochemistry & Cytochemistry. 42:1435-1441

We studied the presence of bacterial antigens in rat tissues. We produced a monoclonal antibody (MAb 2E9) directed against intestinal flora-derived peptidoglycan-polysaccharide complexes from human and rat feces. With several immunological techniques

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83466db1ede5de929480ca474e5a244c
https://doi.org/10.1177/42.11.7930525

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Abstracts of papers

Autor: P. A. v. d. Wouw, H. H. v. Rooy, R. W. Koster, A. J. Porsius, R. G. A. van Wayjen, A. van den Ende, R. G. L. van Tol, T. R. MacGregor, J. Mooy, B. c. Arends, R. Böhm, J. v. Kemenade, M. v. Baak, K. H. Rahn, P. P. Koopmans, Th. Thien, C. M. C. Thomas, F. W. J. Gribnau, J. G. Timmer, A. Vyth, W. Th. Kok, J. M. B. V. de Jong, W. A. den Hartog Jager, J. W. P. M. Overdiek, F. H. H. M. Merkus, M. A. van Bàak, D. de Ryckc, O. Teirlynck, M. G. Bogaert, P. Smits, A. van 't Laar, B. A. M. van Schaik, G. G. Geyskes, J. C. Roos, E. J. Dorhout Mees, G. J. Navis, P. E. de Jong, A. J. M. Donker, G. K. v. d. Hem, D. de Zeeuw, A. H. van den Meiracker, A. J. Man in't Veld, C. J. R. Ritsema, null van Eck, F. H. M. Derkx, M. A. D. H. Schalekamp, J. H. M. Berkelmans, H. Wollersheim, A. C. Dullemond-Westland, J. P. Neijt, J. W. R. Nortier, J. M. A. Sitsen, P. Vermeij, P. M. Edelbroek, M. D. Ferrari, O. J. S. Buruma, F. A. de Wolff, F. Elferink, W. J. F. van der Vijgh, I. Klein, W. W. ten Bokkel Huinink, H. M. Pinedo, M. Raghoebar, H. L. G. M. Tiemessen, P. L. C. M. van Kiel, W. B. van den Berg, C. A. M. van Ginneken

Publikováno v: Pharmacy World & Science. 15:3A-9A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1459bb30df94a7ab5ac0d3e711b8d3b3
https://doi.org/10.1007/bf01884918

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Bone morphogenetic proteins and articular cartilage: To serve and protect or a wolf in sheep clothing's?

Autor: P M, van der Kraan, E N, Blaney Davidson, W B, van den Berg

Publikováno v: Osteoarthritis and cartilage. 18(6)

Alterations in chondrocyte differentiation and matrix remodeling play a central role in osteoarthritis (OA). Chondrocyte differentiation and remodeling are amongst others regulated by the so-called Bone Morphogenetic Proteins (BMPs). Although BMPs ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99dcf96f42eac6899652b51e86013330
https://pubmed.ncbi.nlm.nih.gov/20211748

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TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads

Autor: P M, van der Kraan, E N, Blaney Davidson, A, Blom, W B, van den Berg

Publikováno v: Osteoarthritis and cartilage. 17(12)

Chondrocytes and alteration in chondrocyte differentiation play a central role in osteoarthritis. Chondrocyte differentiation is amongst others regulated by members of the transforming growth factor-beta (TGF-beta) superfamily. The major intracellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6716fa0597f9e5148c5f3ec43ba13051
https://pubmed.ncbi.nlm.nih.gov/19583961

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Fc gamma receptor mediated modulation of dendritic cells as a potential strategy in the battle against rheumatoid arthritis

Autor: M H, Wenink, W B, van den Berg, P L C M, van Riel, T R D J, Radstake

Publikováno v: The Netherlands journal of medicine. 64(4)

Autoimmune diseases such as rheumatoid arthritis (RA) result from a deregulation of immune responses culminating in immune-mediated tissue injury. In RA, this tissue injury is mainly reflected by synovitis and subsequent joint damage, although involv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::01bf0ccba8169d2dd274195afa08a740
https://pubmed.ncbi.nlm.nih.gov/16609156

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Joint inflammation and chondrocyte death become independent of Fcgamma receptor type III by local overexpression of interferon-gamma during immune complex-mediated arthritis

Autor: K C A M, Nabbe, P, Boross, A E M, Holthuysen, A W, Sloëtjes, J K, Kolls, S, Verbeek, P L E M, van Lent, W B, van Den Berg

Publikováno v: Arthritis and rheumatism. 52(3)

It has previously been shown that the onset and the degree of joint inflammation during immune complex (IC)-mediated arthritis depend on Fcgamma receptor type III (FcgammaRIII). Local adenoviral overexpression of interferon-gamma (IFNgamma) in the kn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4119ad6b93096dc9d7943675ae9c9c95
https://pubmed.ncbi.nlm.nih.gov/15751061

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Is there a rationale for combined TNF and IL-1 blocking in arthritis?

Autor: W B, van den Berg

Publikováno v: Clinical and experimental rheumatology. 20(5 Suppl 27)

TNF and IL-1 are master cytokines in chronic destructive arthritis. Therapeutic approaches have so far focused mainly on TNF which is a major inflammatory mediator in RA and a potent inducer of IL-1. Anti-TNF treatment shows great efficacy in RA pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c44ee17d86b111bb7b419c644b52f748
https://pubmed.ncbi.nlm.nih.gov/14989425

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