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Growth hormone secretagogues stimulate the hypothalamic-pituitary-adrenal axis and are diabetogenic in the Zucker diabetic fatty rat

Autor: R G, Clark, G B, Thomas, D L, Mortensen, W B, Won, Y H, Ma, E E, Tomlinson, K M, Fairhall, I C, Robinson

Publikováno v: Endocrinology. 138(10)

Besides stimulating GH release, some GH secretagogues also release ACTH and adrenal steroids. Several novel classes of potent GH secretagogues have recently been described, and we have now tested their ability to release corticosterone in conscious n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02079ae77e6c21bc379eb939805707cc
https://pubmed.ncbi.nlm.nih.gov/9322945

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Growth hormone secretagogues: characterization, efficacy, and minimal bioactive conformation

Autor: R S, McDowell, K A, Elias, M S, Stanley, D J, Burdick, J P, Burnier, K S, Chan, W J, Fairbrother, R G, Hammonds, G S, Ingle, N E, Jacobsen, D L, Mortensen, T E, Rawson, W B, Won, R G, Clark, T C, Somers

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 92(24)

Another class of growth hormone (GH) secretagogues has been discovered by altering the backbone structure of a flexible linear GH-releasing peptide (GHRP). In vitro and in vivo characterization confirms these GH secretagogues as the most potent and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5940b7bac6a0781d7b85eb6382eb704
https://pubmed.ncbi.nlm.nih.gov/7479958

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