Zobrazeno 1 - 10
of 19
pro vyhledávání: '"W A P, Breeman"'
Autor:
Eric P. Krenning, M. de Jong, Theo J. Visser, W. A. P. Breeman, E. de Blois, Dirk Jan Kwekkeboom
Publikováno v:
Anti-Cancer Agents in Medical Chemistry, 7, 345-357. Bentham Science Publishers B.V.
Radiolabelled peptides have shown to be an important class of radiopharmaceuticals for imaging and therapy of malignancies expressing receptors of regulatory peptides. These peptides have high affinity and specificity for their receptors. The majorit
Autor:
Eric P. Krenning, Amir Mearadji, B. F. Bernard, Marion de Jong, Astrid Capello, Casper H.J. van Eijck, W. A. P. Breeman
Publikováno v:
International Journal of Cancer, 104, 376-379. Wiley-Liss Inc.
Peptide receptor scintigraphy with [(111)In-DTPA(0)]octreotide (a stabilized radiolabeled somatostatin (SS) analogue, OctreoScan) is widely used for the visualization and staging of somatostatin receptor-positive tumors. The application of likewise s
Tissue distribution of octreotide binding receptors in normal mice and strains prone to autoimmunity
Autor:
A. M. C. Ten Bokum, P. M. van Hagen, Eric P. Krenning, W. A. P. Breeman, Judith G. M. Rosmalen, Leo J. Hofland
Publikováno v:
Nuclear Medicine Communications, 23, 1009-1017. Lippincott Williams & Wilkins
Somatostatin has diverse functions, including immunomodulatory functions. In humans, sites of active inflammation can be visualized by the administration of 111 In-DTPA°-octreotide, a radiolabelled somatostatin analogue. We wished to establish an an
Autor:
E. P. Krenning, Willem H. Bakker, B. F. Bernard, Ananth Srinivasan, W. A. P. Breeman, M. de Jong, Theo J. Visser
Publikováno v:
Nuclear Medicine Communications. 21:1079-1085
We have evaluated the usefulness of the rat pancreatic CA20948 tumour as an in vitro cell culture model and as an in vivo model in Lewis rats comparing different radiolabelled peptides for receptor-targeted scintigraphy. In vitro the receptor-specifi
Autor:
W. A. P. Breeman, Leo J. Hofland, Helmut R. Mäcke, E. P. Krenning, S. W. J. Lamberts, M. De Jong, P. M. van Koetsveld, Marlijn Waaijers
Publikováno v:
Proceedings of the Association of American Physicians, 111(1), 63-69. Wiley-Blackwell Publishing Ltd
We compared internalization of three radioiodinated octreotide (OCT) somatostatin (SS) analogs-[125I-Tyr3]OCT, [DTPA degrees, 125I-Tyr3]OCT, and [DOTA degrees,125I-Tyr3]OCT-by somatostatin receptor (SSR)-positive mouse AtT20 pituitary tumor cells and
Autor:
R P J, Schroeder, E, De Blois, C M A, De Ridder, W M, Van Weerden, W A P, Breeman, M, de Jong
Publikováno v:
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... 56(5)
Prostate cancer (PC) is a major health problem. The Gastrin-Releasing Peptide Receptor (GRPR) offers a promising target for staging and monitoring of PC since it is overexpressed in PC and not in normal prostatic tissue. To improve receptor-mediated
Autor:
S. W. J. Lamberts, W. A. P. Breeman, Leo J. Hofland, M. E. Van Der Pluijm, T. J. Visser, E. P. Krenning, P. M. van Koetsveld, B. Setyono-Han, Willem H. Bakker, Dirk Jan Kwekkeboom, M. De Jong
Publikováno v:
European Journal of Nuclear Medicine. 21:328-335
We have evaluated the potential usefulness of indium-111 labelled [DTPA-D-Phe1]RC-160, derived from the octapeptide somatostatin analogue RC-160, as a radiopharmaceutical for the in vivo detection of somatostatin receptor-positive tumours. For this p
Publikováno v:
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... 50(4)
Lutetium-177 is increasingly used in patients for receptor-targeted radionuclide therapy with peptides such as [DOTA0,Tyr3]octreotate. In our therapy facility, we are performing yearly 400 treatments with each 7.4 GBq [177Lu][DOTA0,Tyr3]octreotate. F
Autor:
Katy van der Wansem, Theo J. Visser, Eric P. Krenning, Jack L. Erion, M. de Jong, Arthur van Gameren, W. A. P. Breeman, B. F. Bernard
Publikováno v:
European journal of nuclear medicine and molecular imaging. 30(2)
Peptide receptor-targeted radionuclide therapy is nowadays also being performed with DOTA-conjugated peptides, such as [DOTA(0),Tyr(3)]octreotate, labelled with radionuclides like (177)Lu. The incorporation of (177)Lu is typically/=99.5%; however, si
Autor:
M. De Jong, B. F. Bernard, Willem H. Bakker, T. J. Visser, E. De Bruin, A. van Gameren, M. E. Van Der Pluijm, W. A. P. Breeman, Helmut R. Mäcke, E. P. Krenning
Publikováno v:
European journal of nuclear medicine. 26(7)
Radiolabelled tumour receptor-binding peptides can be used for in vivo scintigraphic imaging. Recently, the somatostatin analogue [Tyr3]octreotide (D-Phe-c(Cys-Tyr-D-Trp-Lys-Thr-Cys)-Thr(ol)) was derivatized with the chelator DOTA (tetra-azacyclodode