Výsledky vyhledávání

Akademický článek

PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

Autor: Daniela Nasteska, Nicholas H. F. Fine, Fiona B. Ashford, Federica Cuozzo, Katrina Viloria, Gabrielle Smith, Aisha Dahir, Peter W. J. Dawson, Yu-Chiang Lai, Aimée Bastidas-Ponce, Mostafa Bakhti, Guy A. Rutter, Remi Fiancette, Rita Nano, Lorenzo Piemonti, Heiko Lickert, Qiao Zhou, Ildem Akerman, David J. Hodson

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Beta cell subpopulations with low expression in PDX1, MAFA, and insulin might contribute to islet function and insulin release. Here the authors show that altering the proportion of PDX1LOW MAFALOW to PDX1HIGH MAFAHIGH cells impairs islet function.

Externí odkaz: https://doaj.org/article/cf504598ffd644018cbb1c9c1fc2bf2c

Zobrazit plný text záznamu

Ubiquitin E3 ligases Atrogin-1 and MuRF1 protein contents are differentially regulated in the rapamycin-sensitive mTOR-S6K1 signaling pathway in C2C12 myotubes

Autor: Yusuke Nishimura, Peter W. J. Dawson, Lars Holm, Ibrahim Musa, Yu-Chiang Lai

Muscle-specific ubiquitin E3 ligases, Atrogin-1 and MuRF1, are highly expressed in multiple conditions of skeletal muscle atrophy. The PI3K/Akt/FoxO signaling pathway is well known to regulate Atrogin-1 and MuRF1 gene expressions. Evidence supporting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48b2d798ca6c6b86efb3a313e01194f1
https://doi.org/10.1101/2021.10.15.463676

Zobrazit plný text záznamu

PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

Autor: David J. Hodson, Federica Cuozzo, Peter W. J. Dawson, Remi Fiancette, Aisha Dahir, Katrina Viloria, Daniela Nasteska, Mostafa Bakhti, Ildem Akerman, Qiao Zhou, Fiona B. Ashford, Gabrielle Smith, Heiko Lickert, Rita Nano, Aimée Bastidas-Ponce, Yu-Chiang Lai, Nicholas H. F. Fine, Guy A. Rutter, Lorenzo Piemonti

Publikováno v: Nat. Commun. 12:674 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Transcriptionally mature and immature β-cells co-exist within the adult islet. How such diversity contributes to insulin release remains poorly understood. Here we show that subtle differences in β-cell maturity, defined using PDX1 and MAFA express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed6129b09188b234293ada2d9e691a2
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=61196

Zobrazit plný text záznamu

PDX1

Autor: Daniela, Nasteska, Nicholas H F, Fine, Fiona B, Ashford, Federica, Cuozzo, Katrina, Viloria, Gabrielle, Smith, Aisha, Dahir, Peter W J, Dawson, Yu-Chiang, Lai, Aimée, Bastidas-Ponce, Mostafa, Bakhti, Guy A, Rutter, Remi, Fiancette, Rita, Nano, Lorenzo, Piemonti, Heiko, Lickert, Qiao, Zhou, Ildem, Akerman, David J, Hodson

Publikováno v: Nature Communications

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e8d917ea22cbe2c792badee468f8053
https://pubmed.ncbi.nlm.nih.gov/34285239

Zobrazit plný text záznamu

Unique Science from a Coordinated LSST-WFIRST Survey of the Galactic Bulge

Autor: R Street, E T Al, N R Golovich, W A Dawson

NASA's WFIRST mission will perform a wide-field, NIR survey of the Galactic Bulge to search for exoplanets via the microlensing techniques. As the mission is due to launch in the mid-2020s, around half-way through the LSST Main Survey, we have a uniq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2de0a85daaf53574c5157f4d900de067
https://doi.org/10.2172/1572250

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání