Výsledky vyhledávání - "W A (Fried) Faassen"

Lymphatic transport of Methylnortestosterone undecanoate (MU) and the bioavailability of methylnortestosterone are highly sensitive to the mass of coadministered lipid after oral administration of MU

Autor: Glenn A. Edwards, Christopher J.H. Porter, Karen L. White, W A (Fried) Faassen, William N. Charman, Gary Nguyen

Publikováno v: The Journal of pharmacology and experimental therapeutics. 331(2)

The contribution of lymphatic transport to the oral bioavailability of methylnortestosterone (M) after oral administration of the lipophilic prodrug methylnortestosterone undecanoate (MU) has been evaluated, and the sensitivity of lymphatic MU transp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41ad71d990a61cb6b0b9b5e4e9ec198
https://pubmed.ncbi.nlm.nih.gov/19696095

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Oral bioavailability assessment and intestinal lymphatic transport of Org 45697 and Org 46035, two highly lipophilic novel immunomodulator analogues

Autor: Gerard M. T. Vogel, Christopher J.H. Porter, Suzanne Mary Caliph, W A (Fried) Faassen

Publikováno v: Current drug delivery. 6(4)

Org 45697 (MW 600.7, clogP 7.92, soybean oil solubility 50 mg/g) and Org 46035 (MW 601.6, clog P 8.46, soybean oil solubility 40 mg/g) are two poorly water soluble (0.1 microg/ml), highly lipophilic drug candidates with immunomodulator activity and h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98eafc1f953a5e25f01def54991ce9b1
https://pubmed.ncbi.nlm.nih.gov/19534711

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Contribution of lymphatically transported testosterone undecanoate to the systemic exposure of testosterone after oral administration of two andriol formulations in conscious lymph duct-cannulated dogs

Autor: W A (Fried) Faassen, Christopher J.H. Porter, David M. Shackleford, Glenn A. Edwards, Natalie Houwing, Holger Lass, William N. Charman

Publikováno v: The Journal of pharmacology and experimental therapeutics. 306(3)

Orally administered testosterone (T) is ineffective in the treatment of male androgen deficiency syndromes due to extensive presystemic first-pass metabolism. In contrast, the lipophilic long-chain ester testosterone undecanoate (TU) exhibits androge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a378849e3f617074f7965dfab9a5fc
https://pubmed.ncbi.nlm.nih.gov/12807999

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