Zobrazeno 1 - 10
of 205
pro vyhledávání: '"W A, Ritschel"'
Autor:
B S, Kuo, W A, Ritschel
Publikováno v:
Pharmaceutical research. 3(3)
In crossover studies rabbits were given sulfmpyrazone (SO) and its sulfide metabolite (S) perorally once daily (10 mg/kg) for 5 days. Comparison of the pharmacokinetic parameters obtained after the first and the fifth dose indicates that repeated dos
Autor:
W A, Ritschel
Publikováno v:
Pharmaceutical research. 3(3)
In rabbits receiving sulfmpyrazone (SO) and the sulfide metabolite (S) in four separate experiments, the biotransformation of SO into S was found to be reversible, which resulted in approximately parallel terminal disposition profiles for the three m
Autor:
W. A. Ritschel
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 18:101-111
Risks associated with drug therapy are more prevalent with advancing age. In drug evaluation it is imperative to identify risk groups. Six strategies are discussed to identify risk groups: (a) from physico-chemical, preclinical drug data, and expecte
Publikováno v:
Journal of Applied Polymer Science. 42:2409-2416
The equilibrium and dynamic swelling behavior of glassy polymers immersed in solvents can be modified by controlling the history of the polymer sample, which includes prior swelling and the drying method, or by copolymerization with other monomers. I
Autor:
S. Kaul, W. A. Ritschel
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 15:211-217
The pharmacokinetics of a series of sulfonamides were investigated after intravenous administration of a 7 mg/kg dose of individual sulfonamides to cannulated female lean Zucker rats. The concentrations of the sulfonamides in blood were determined by
Publikováno v:
Drug Development and Industrial Pharmacy. 16:963-981
The phsical properties of sucrose-lactoes-strach granulations containing a water soluble drug are characterized, and the relationship between granulaion kneading time and each of the these properties is examined. In addition, the effect of granulatio
Publikováno v:
Clinical pharmacology and therapeutics. 81(4)
Autor:
W A Ritschel
Publikováno v:
Clinical Pharmacology & Therapeutics. 81:480-481
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 19(5)
The purpose of this investigation was to compare the permeation characteristics of two different compounds (extremely polar and nonpolar), i.e., tritium-labeled water (W) and 14C-labeled 7-hydroxycoumarin (7-OHC), among 16 different species, includin
Autor:
H, Forusz, W A, Ritschel
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 19(1)
A human study examined the effect of administering a triethanolamine myristate tablet 30 min prior to or concomitantly with a fast release riboflavin tablet and a slow release riboflavin tablet. There was no significant difference between any of the