Zobrazeno 1 - 10
of 273
pro vyhledávání: '"W A, Hubbard"'
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-11 (2024)
Abstract Background Neurovascular deficits and blood-brain barrier (BBB) dysfunction are major hallmarks of brain trauma and neurodegenerative diseases. Oxidative stress is a prominent contributor to neurovascular unit (NVU) dysfunction and can propa
Externí odkaz:
https://doaj.org/article/8d19da83d2eb481bbbae4c4b44e9816e
Autor:
M. W. J. Hubbard, O. Hetherington, D. J. Hall, T. W. Buggey, S. Parsons, T. Arnold, A. Holland, C. Pagani, S. Sembay
Publikováno v:
Earth and Planetary Physics, Vol 8, Iss 1, Pp 15-24 (2024)
The ESA and CAS SMILE mission orbit is highly elliptical and will pass through multiple radiation environments. The Soft X-ray Imager (SXI) instrument aboard has a radiation shutter door designed to close when the surrounding radiation flux is high.
Externí odkaz:
https://doaj.org/article/03db3763fce6437db8c4562226bb64ce
Autor:
S. Sembay, A. L. Alme, D. Agnolon, T. Arnold, A. Beardmore, A. Belén Balado Margeli, C. Bicknell, C. Bouldin, G. Branduardi-Raymont, T. Crawford, J. P. Breuer, T. Buggey, G. Butcher, R. Canchal, J. A. Carter, A. Cheney, Y. Collado-Vega, H. Connor, N. Eaton, C. Feldman, C. Forsyth, T. Frantzen, G. Galgóczi, J. Garcia, G. Y. Genov, C. Gordillo, H-P. Gröbelbauer, M. Guedel, Y. Guo, M. Hailey, D. Hall, R. Hampson, J. Hasiba, O. Hetherington, A. Holland, S-Y. Hsieh, M. W. J. Hubbard, H. Jeszenszky, M. Jones, T. Kennedy, K. Koch-Mehrin, S. Kögl, S. Krucker, K. D. Kuntz, C. Lakin, G. Laky, O. Lylund, A. Martindale, J. Miguel Mas Hesse, R. Nakamura, K. Oksavik, N. Østgaard, H. Ottacher, R. Ottensamer, C. Pagani, S. Parsons, P. Patel, J. Pearson, G. Peikert, F. S. Porter, T. Pouliantis, B. H. Qureshi, W. Raab, G. Randall, A. M. Read, N. M. M. Roque, M. E. Rostad, C. Runciman, S. Sachdev, A. Samsonov, M. Soman, D. Sibeck, S. Smit, J. Søndergaard, R. Speight, S. Stavland, M. Steller, TianRan Sun, J. Thornhill, W. Thomas, K. Ullaland, B. Walsh, D. Walton, C. Wang, S. Yang
Publikováno v:
Earth and Planetary Physics, Vol 8, Iss 1, Pp 5-14 (2024)
The Soft X-ray Imager (SXI) is part of the scientific payload of the Solar wind Magnetosphere Ionosphere Link Explorer (SMILE) mission. SMILE is a joint science mission between the European Space Agency (ESA) and the Chinese Academy of Sciences (CAS)
Externí odkaz:
https://doaj.org/article/6b19bd85a1e24e6fbe503471fa9df545
Autor:
S. Parsons, D. J. Hall, O. Hetherington, T. W. Buggey, T. Arnold, M. W. J. Hubbard, A. Holland
Publikováno v:
Earth and Planetary Physics, Vol 8, Iss 1, Pp 25-38 (2024)
Throughout the SMILE mission the satellite will be bombarded by radiation which gradually damages the focal plane devices and degrades their performance. In order to understand the changes of the CCD370s within the soft X-ray Imager, an initial chara
Externí odkaz:
https://doaj.org/article/9bd799e25ff64042bbcffc3edb3614c6
Autor:
M. A. Zouache, B. T. Richards, C. M. Pappas, R. A. Anstadt, J. Liu, T. Corsetti, S. Matthews, N. A. Seager, S. Schmitz-Valckenberg, M. Fleckenstein, W. C. Hubbard, J. Thomas, J. L. Hageman, B. L. Williams, G. S. Hageman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Dysregulation of the alternative pathway (AP) of the complement system is a significant contributor to age-related macular degeneration (AMD), a primary cause of irreversible vision loss worldwide. Here, we assess the contribution of the liv
Externí odkaz:
https://doaj.org/article/5509274071cb4770a0b493d6e99eb582
Autor:
Olivia J. Kalimon, Hemendra J. Vekaria, Gopal V. Velmurugan, W. Brad Hubbard, Patrick G. Sullivan
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 627-642 (2023)
Traumatic brain injury (TBI) is caused by an impact or penetrating injury to the head resulting in abnormal brain function. Mitochondrial dysfunction is an important hallmark of TBI and has been thoroughly studied in male rodent models of brain injur
Externí odkaz:
https://doaj.org/article/546dfda817774a33880b1afc465a2a50
Autor:
Olivia J. Kalimon, Hemendra J. Vekaria, Paresh Prajapati, Sydney L. Short, W. Brad Hubbard, Patrick G. Sullivan
Publikováno v:
Life, Vol 14, Iss 8, p 961 (2024)
Current literature finds females have improved outcomes over their male counterparts after severe traumatic brain injury (TBI), while the opposite seems to be true for mild TBI. This begs the question as to what may be driving these sex differences a
Externí odkaz:
https://doaj.org/article/86fa9c68ca5d49339128bb6c6eece016
Autor:
Madison O. Kilgore, W. Brad Hubbard
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 642 (2024)
Low-level blast (LLB) exposure can lead to alterations in neurological health, cerebral vasculature, and cerebral blood flow (CBF). The development of cognitive issues and behavioral abnormalities after LLB, or subconcussive blast exposure, is insidi
Externí odkaz:
https://doaj.org/article/bc9b6562c4734dd4a56859aad7054e6a
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract Low-level blast exposure can result in neurological impairment for military personnel. Currently, there is a lack of experimental data using sex as a biological variable in neurovascular outcomes following blast exposure. To model mild blast
Externí odkaz:
https://doaj.org/article/2ca1afccba564370b3fcad45d3e5f777
Autor:
Gopal V. Velmurugan, W. Brad Hubbard, Paresh Prajapati, Hemendra J. Vekaria, Samir P. Patel, Alexander G. Rabchevsky, Patrick G. Sullivan
Publikováno v:
Cells, Vol 12, Iss 10, p 1445 (2023)
The brain undergoes oxidative stress and mitochondrial dysfunction following physiological insults such as Traumatic brain injury (TBI), ischemia-reperfusion, and stroke. Pharmacotherapeutics targeting mitochondria (mitoceuticals) against oxidative s
Externí odkaz:
https://doaj.org/article/9f94aa251cc2430e9f7a742e04917022