Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes

Autor: J, Yang, Å, Lernmark, U M, Uusitalo, K F, Lynch, R, Veijola, C, Winkler, H E, Larsson, M, Rewers, J-X, She, A G, Ziegler, O G, Simell, W A, Hagopian, B, Akolkar, J P, Krischer, K, Vehik, Dan, Gallo

Publikováno v: International journal of obesity (2005)
Int. J. Obes. 38, 1491-1496 (2014)
International Journal of Obesity; 38(12), pp 1491-1496 (2014)

Objectives:Body size is postulated to modulate type 1 diabetes as either a trigger of islet autoimmunity or an accelerator to clinical onset after seroconversion. As overweight and obesity continue to rise among children, the aim of this study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7612d88a43db2944943fe60dd53def64
https://pubmed.ncbi.nlm.nih.gov/24694666

Glutamate decarboxylase antibody levels predict rate of β-cell decline in adult-onset diabetes

Autor: Anders Gottsäter, Mona Landin-Olsson, P. Fernlund, W. A. Hagopian, G. Sundkvist, Åke Lernmark

Publikováno v: Diabetes Research and Clinical Practice. 27:133-140

Glutamate decarboxylase autoantibodies (GAD65Ab) and beta-cell function were evaluated at and 3 years after diabetes onset in consecutive subjects over 15 years of age. At onset, 21/32 (66%) insulin-treated patients (mean age 43, range 16-79 years) h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed99e4456f16b1829e3f68caa826b77
https://doi.org/10.1016/0168-8227(95)01026-a

Analysis of antibody markers, DRB1, DRB5, DQA1 and DQB1 genes and modeling of DR2 molecules in DR2-positive patients with insulin-dependent diabetes mellitus

Autor: Carani B. Sanjeevi, Terry P. Lybrand, Mona Landin-Olsson, Ingrid Kockum, Åke Lernmark, Gisela Dahlquist, Jerry P. Palmer, W. A. Hagopian

Publikováno v: Tissue Antigens. 44:110-119

HLA‐DR2 is negatively associated with insulin‐dependent diabetes mellitus (IDDM). The aim of the present study was to analyze DR2‐positive patients among 425 consecutively diagnosed unrelated Swedish children with IDDM and in 367 matched contro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7db151800b97c2d4d610bc5b24c5780
https://doi.org/10.1111/j.1399-0039.1994.tb02366.x

Autoantibodies in IDDM primarily recognize the 65,000-M(r) rather than the 67,000-M(r) isoform of glutamic acid decarboxylase

Autor: W. A. Hagopian, B. Michelsen, A. E. Karlsen, F. Larsen, A. Moody, C. E. Grubin, R. Rowe, J. Petersen, R. McEvoy, A. Lernmark

Publikováno v: Diabetes. 42:631-636

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9257a7920a34267378a215075c75f600
https://doi.org/10.2337/diabetes.42.4.631

Association between autoantibody markers and subtypes of DR4 and DR4-DQ in Swedish children with insulin-dependent diabetes reveals closer association of tyrosine pyrophosphatase autoimmunity with DR4 than DQ8

Autor: J.P. Palmer, W. A. Hagopian, W Woo, Åke Lernmark, Mona Landin-Olsson, Gisela Dahlquist, Ingrid Kockum, Carani B. Sanjeevi

Publikováno v: Karolinska Institutet
Europe PubMed Central

HLA DQA1(*)0301-DQB1(*)0302 (DQ8) and DQA1(*)0501-DQB1(*)0201 (DQ2) are positively and DQA1(*)0102-DQB1(*)0602 (DQ6) negatively associated with IDDM. In DQA1(*)0301-DQB1(*)0302 (DQ8)-positive patients, susceptibility is also mediated by DRB1(*)0401.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef4563a453da1bd1a1c9436fe7a6d3f
https://pubmed.ncbi.nlm.nih.gov/9550329