Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Włodzimierz, Buczko"'
Autor:
Włodzimierz Buczko, Bogusław Okopień, Dagmara Mirowska-Guzel, Krzysztof J. Filipiak, Filip M. Szymański, Tomasz Kocki
Publikováno v:
Folia Cardiologica. 15:114-117
Publikováno v:
European Journal of Pharmacology. 259:315-319
In pithed rats, we studied the effects of prostaglandin E2 and of subtype-selective prostaglandin E receptor (EP receptor) ligands on the rise in blood pressure induced by electrical stimulation of the preganglionic sympathetic nerves. Prostaglandin
Autor:
Piotr, Myśliwiec, Hanna, Myśliwiec, Dariusz, Pawlak, Jacek, Dadan, Włodzimierz, Buczko, Krystyna, Pawlak
Publikováno v:
Przeglad lekarski. 66(3)
Disturbances in amino acids metabolism are common in chronic renal failure and subside partially after renal tranplantation. Tryptophan (TRP) is one of the most important exogenous amino acids. Its main derivative is L-kynurenine (KYN). Disorders in
Publikováno v:
Pharmacological reports : PR. 60(6)
Animal models of asthma have been used for over 100 years. The accuracy of extrapolations from animal models to human asthmatics is highly dependent on the species of animal selected. The rat, in comparison with other animals, demonstrates many featu
Publikováno v:
Pharmacological reports : PR. 60(5)
Intensive efforts have been spent to discover therapeutic, non-peptide and orally effective hypertensive drugs. One drug that emerged from this effort is aliskiren, a direct human renin inhibitor that blocks the conversion of angiotensinogen to angio
Publikováno v:
Pharmacological reports : PR. 60(6)
N-methylnicotinamide, a nicotinamide derivative, possesses anti-thrombotic activity, although the mechanism of its action is unclear. Using a rat model of isolated perfused hindlimb, we tested whether this metabolite of nicotinamide is able to inhibi
Publikováno v:
Pharmacological reports : PR.
The endothelial mechanism of ACE-Is action is multifaceted. On the one hand, by inhibiting ACE, ACE-Is diminish Ang II synthesis, one of the best known active peptides. On the other hand, they modify synthesis and release of PGI(2) and NO via increas
Publikováno v:
Przeglad lekarski. 61(12)
Oxygen, carried mainly by erythrocytes, plays a crucial role in human organisms--as the terminal electron acceptor enables mitochondria functioning and energy production. Oxygen excess may be a cause of the damage of basic structural organism compone
Publikováno v:
Postepy higieny i medycyny doswiadczalnej (Online). 59
In this review, the role of the kynurenine pathway enzymes TDO (tryptophan 2,3 dioxygenase) and IDO (indoleamine 2,3 -dioxygenase) as well as the properties of the metabolites of kynurenine degradation present in human saliva described. The implicati
Publikováno v:
Pharmacological reports : PR. 57(1)
In the present study, we have shown considerably accelerated thrombosis in old rats in comparison with adult rats, which may be related to the impaired hemostatic balance in these animals. In old rats, captopril and enalapril caused a marked reductio