Therapeutic Drug Monitoring of Asparaginase: Intra-individual Variability and Predictivity in Children With Acute Lymphoblastic Leukemia Treated With PEG-Asparaginase in the AIEOP-BFM Acute Lymphoblastic Leukemia 2009 Study.

Autor: Würthwein G; Department of Pediatric Hematology and Oncology, University Children's Hospital of Münster, Münster, Germany., Lanvers-Kaminsky C; Department of Pediatric Hematology and Oncology, University Children's Hospital of Münster, Münster, Germany., Gerss J; Institute of Biostatistics and Clinical Research, University Münster, Münster, Germany., Möricke A; Department of General Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany., Zimmermann M; Department of Pediatric Hematology and Oncology, Hannover Medical School, Germany., Stary J; Department of Pediatric Hematology and Oncology, Charles University and University Hospital, Motol, Prague, Czech Republic., Smisek P; Department of Pediatric Hematology and Oncology, Charles University and University Hospital, Motol, Prague, Czech Republic., Attarbaschi A; Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria., Nath C; Departments of Biochemistry and Oncology, The Children's Hospital at Westmead, Faculty of Pharmacy, University of Sydney, Sydney, Australia., Zucchetti M; Department of Oncology, Laboratory of Cancer Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy; and., Rizzari C; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy., Schrappe M; Department of General Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany., Boos J; Department of Pediatric Hematology and Oncology, University Children's Hospital of Münster, Münster, Germany.

Publikováno v: Therapeutic drug monitoring [Ther Drug Monit] 2020 Jun; Vol. 42 (3), pp. 435-444.

Population pharmacokinetic modelling of imatinib in healthy subjects receiving a single dose of 400 mg.

Autor: Chien YH; Westfälische Wilhelms-Universität Münster, Institut für Pharmazeutische und Medizinische Chemie-Klinische Pharmazie, Corrensstraße 48, 48149, Münster, Germany., Würthwein G; Westfälische Wilhelms-Universität Münster, Institut für Pharmazeutische und Medizinische Chemie-Klinische Pharmazie, Corrensstraße 48, 48149, Münster, Germany., Zubiaur P; Clinical Pharmacology Department, Hospital Universitario de la Princesa, Pharmacology Department, Faculty of Medicine, Universidad Autonoma de Madrid, Instituto de Investigación Sanitaria la Princesa (IIS-Princesa), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Diego de León 62, 28006, Madrid, Spain., Posocco B; Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Via Franco Gallini, 2, 33081, Aviano, PN, Italy., Pena MÁ; Farmacología Clínica, Hospital Universitario Marqués de Valdecilla-Pabellón, 15-planta 2 Avda. Valdecilla s/n., 39008, Santander, Cantabria, Spain., Borobia AM; Clinical Pharmacology Department, Hospital Universitario La Paz, Pharmacology Department, Faculty of Medicine, Universidad Autonoma de Madrid, IdiPAZ, Madrid, Spain., Gagno S; Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Via Franco Gallini, 2, 33081, Aviano, PN, Italy., Abad-Santos F; Clinical Pharmacology Department, Hospital Universitario de la Princesa, Pharmacology Department, Faculty of Medicine, Universidad Autonoma de Madrid, Instituto de Investigación Sanitaria la Princesa (IIS-Princesa), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Diego de León 62, 28006, Madrid, Spain., Hempel G; Westfälische Wilhelms-Universität Münster, Institut für Pharmazeutische und Medizinische Chemie-Klinische Pharmazie, Corrensstraße 48, 48149, Münster, Germany. georg.hempel@uni-muenster.de.

Publikováno v: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2022 Aug; Vol. 90 (2), pp. 125-136. Date of Electronic Publication: 2022 Jul 14.

Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia.

Autor: Khalil A; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster., Würthwein G; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster., Golitsch J; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster., Hempel G; Department of Pharmaceutical and Medical Chemistry, Clinical Pharmacy, University of Muenster., Fobker M; Center of Laboratory Medicine, University Hospital Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster., Gerss J; Institute of Biostatistics and Clinical Research, University of Muenster., Möricke A; Department of Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel., Zimmermann M; Department of Pediatric Hematology and Oncology, Medical School Hannover., Smisek P; Department of Pediatric Hematology and Oncology, University Hospital Motol, Praha, Czech Republic., Zucchetti M; Laboratory of Cancer Pharmacology, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan., Nath C; Departments of Biochemistry and Oncology, The Children's Hospital at Westmead, Sydney Pharmacy School, University of Sydney, Sydney., Attarbaschi A; Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna., Von Stackelberg A; Departments of Pediatric Oncology/Hematology and of General Pediatrics, Charité - University Medicine Berlin, Berlin., Gökbuget N; Department of Medicine, University Hospital, Frankfurt a.M., Rizzari C; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, ASST-Monza, Monza., Conter V; Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, ASST-Monza, Monza., Schrappe M; Department of Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel., Boos J; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster., Lanvers-Kaminsky C; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster. lanvers@uni-muenster.de.

Publikováno v: Haematologica [Haematologica] 2022 Jan 01; Vol. 107 (1), pp. 49-57. Date of Electronic Publication: 2022 Jan 01.

Acute Myeloid Leukaemia and Acute Lymphoblastic Leukaemia Classification and Metabolic Characteristics for Informing and Advancing Treatment.

Autor: Wemyss, Carrie^1,2 (AUTHOR) c.wemyss@uea.ac.uk, Jones, Emily¹ (AUTHOR) emily.jones@quadram.ac.uk, Stentz, Régis¹ (AUTHOR) regis.stentz@quadram.ac.uk, Carding, Simon R.^1,2 (AUTHOR) simon.carding@quadram.ac.uk

Publikováno v: Cancers. Dec2024, Vol. 16 Issue 24, p4136. 19p.

Population pharmacokinetic evaluation of cefuroxime in perioperative antibiotic prophylaxis during and after cardiopulmonary bypass.

Autor: Rimmler C; Department of Pharmaceutical and Medical Chemistry-Clinical Pharmacy, Muenster, Germany., Lanckohr C; Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, Muenster, Germany., Mittrup M; Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, Muenster, Germany., Welp H; Department of Cardiac Surgery, University Hospital Muenster, Muenster, Germany., Würthwein G; Department of Pharmaceutical and Medical Chemistry-Clinical Pharmacy, Muenster, Germany., Horn D; Department of Pharmacy, University Hospital of Muenster, Muenster, Germany., Fobker M; Center for Laboratory Medicine, University Hospital Muenster, Muenster, Germany., Ellger B; Department of Anesthesiology, Intensive Care and Pain Medicine, Klinikum Westfalen, Dortmund, Germany., Hempel G; Department of Pharmaceutical and Medical Chemistry-Clinical Pharmacy, Muenster, Germany.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2021 Mar; Vol. 87 (3), pp. 1486-1498. Date of Electronic Publication: 2020 Nov 17.