SGLT2 Inhibitors Decrease Overhydration and Proteasuria in Patients with Chronic Kidney Disease: A Longitudinal Observational Study.

Autor: Schork A; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany., Eberbach ML; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany., Bohnert BN; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany., Wörn M; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany., Heister DJ; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany., Eisinger F; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany., Vogel E; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany., Heyne N; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany., Birkenfeld AL; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany., Artunc F; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany.

Publikováno v: Kidney & blood pressure research [Kidney Blood Press Res] 2024; Vol. 49 (1), pp. 124-134. Date of Electronic Publication: 2024 Jan 16.

Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice.

Autor: Wörner S; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Bohnert BN; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD) at the University Tübingen, Tübingen, Germany., Wörn M; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Xiao M; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Janessa A; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Birkenfeld AL; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD) at the University Tübingen, Tübingen, Germany., Amann K; Department of Nephropathology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg (FAU), Erlangen, Germany., Daniel C; Department of Nephropathology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg (FAU), Erlangen, Germany., Artunc F; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany. ferruh.artunc@med.uni-tuebingen.de.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tübingen, Germany. ferruh.artunc@med.uni-tuebingen.de.; German Center for Diabetes Research (DZD) at the University Tübingen, Tübingen, Germany. ferruh.artunc@med.uni-tuebingen.de.

Publikováno v: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2022 Jan; Vol. 43 (1), pp. 111-120. Date of Electronic Publication: 2021 Mar 23.

Sodium retention in nephrotic syndrome is independent of the activation of the membrane-anchored serine protease prostasin (CAP1/PRSS8) and its enzymatic activity.

Autor: Essigke D; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Otfried-Mueller-Str.10, 72076, Tuebingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tuebingen, Germany.; German Center for Diabetes Research (DZD) at the University Tübingen, Tuebingen, Germany., Bohnert BN; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Otfried-Mueller-Str.10, 72076, Tuebingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tuebingen, Germany.; German Center for Diabetes Research (DZD) at the University Tübingen, Tuebingen, Germany., Janessa A; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Otfried-Mueller-Str.10, 72076, Tuebingen, Germany., Wörn M; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Otfried-Mueller-Str.10, 72076, Tuebingen, Germany., Omage K; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Otfried-Mueller-Str.10, 72076, Tuebingen, Germany., Kalbacher H; Interfacultary Institute for Biochemistry, Tuebingen, Germany., Birkenfeld AL; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Otfried-Mueller-Str.10, 72076, Tuebingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tuebingen, Germany.; German Center for Diabetes Research (DZD) at the University Tübingen, Tuebingen, Germany., Bugge TH; Proteases and Tissue Remodeling Section, NIDCR, National Institutes of Health, Bethesda, MD, USA., Szabo R; Proteases and Tissue Remodeling Section, NIDCR, National Institutes of Health, Bethesda, MD, USA., Artunc F; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Otfried-Mueller-Str.10, 72076, Tuebingen, Germany. ferruh.artunc@med.uni-tuebingen.de.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tuebingen, Germany. ferruh.artunc@med.uni-tuebingen.de.; German Center for Diabetes Research (DZD) at the University Tübingen, Tuebingen, Germany. ferruh.artunc@med.uni-tuebingen.de.

Publikováno v: Pflugers Archiv : European journal of physiology [Pflugers Arch] 2022 Jun; Vol. 474 (6), pp. 613-624. Date of Electronic Publication: 2022 Mar 21.

Proteinuric chronic kidney disease is associated with altered red blood cell lifespan, deformability and metabolism.

Autor: Bissinger R; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Nemkov T; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA; Division of Hematology, University of Colorado Denver, Aurora, Colorado, USA., Grau M; Institute of Molecular and Cellular Sports Medicine, German Sport University of Cologne, Köln, Germany., Dietz T; Institute of Molecular and Cellular Sports Medicine, German Sport University of Cologne, Köln, Germany., Bohnert BN; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD) at the University Tübingen, Tübingen, Germany., Essigke D; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Wörn M; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Schaefer L; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Xiao M; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Beirne JM; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Kalo MZ; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Schork A; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD) at the University Tübingen, Tübingen, Germany., Bakchoul T; Center for Clinical Transfusion Medicine, University Hospital of Tübingen, Tübingen, Germany., Omage K; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Kong L; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Gonzalez-Menendez I; Department of Pathology, Eberhard Karls University Tübingen, Tübingen, Germany., Quintanilla-Martinez L; Department of Pathology, Eberhard Karls University Tübingen, Tübingen, Germany., Fehrenbacher B; Department of Dermatology, Eberhard Karls University Tübingen, Tübingen, Germany., Schaller M; Department of Dermatology, Eberhard Karls University Tübingen, Tübingen, Germany., Dhariwal A; Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway., Birkenfeld AL; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD) at the University Tübingen, Tübingen, Germany., Grahammer F; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Qadri SM; Faculty of Health Sciences, Ontario Tech University, Oshawa, Ontario, Canada., Artunc F; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD) at the University Tübingen, Tübingen, Germany. Electronic address: ferruh.artunc@med.uni-tuebingen.de.

Publikováno v: Kidney international [Kidney Int] 2021 Dec; Vol. 100 (6), pp. 1227-1239. Date of Electronic Publication: 2021 Sep 16.

Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.

Autor: Bohnert BN; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD) at the University Tübingen, Tübingen, Germany., Daiminger S; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany., Wörn M; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany., Sure F; Institute of Cellular and Molecular Physiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Bayern, Germany., Staudner T; Institute of Cellular and Molecular Physiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Bayern, Germany., Ilyaskin AV; Institute of Cellular and Molecular Physiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Bayern, Germany., Batbouta F; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany., Janessa A; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany., Schneider JC; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany., Essigke D; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany., Kanse S; Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway., Haerteis S; Institute of Anatomy, University of Regensburg, Regensburg, Germany., Korbmacher C; Institute of Cellular and Molecular Physiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Bayern, Germany., Artunc F; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD) at the University Tübingen, Tübingen, Germany.

Publikováno v: Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2019 Dec; Vol. 227 (4), pp. e13286. Date of Electronic Publication: 2019 May 20.