Výsledky vyhledávání - "W, van Duijn"

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Akademický článek

Characterization of Heterogeneous Prostate Tumors in Targeted Pten Knockout Mice.

Autor: Hanneke Korsten, Angelique C J Ziel-van der Made, Wytske M van Weerden, Theo van der Kwast, Jan Trapman, Petra W Van Duijn

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0147500 (2016)

Previously, we generated a preclinical mouse prostate tumor model based on PSA-Cre driven inactivation of Pten. In this model homogeneous hyperplastic prostates (4-5m) developed at older age (>10m) into tumors. Here, we describe the molecular and his

Externí odkaz: https://doaj.org/article/04529b4168a7415d832f1d571e13be43

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Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras -driven lung tumours

Publikováno v: The Journal of Pathology. 245:101-113

A key question in precision medicine is how functional heterogeneity in solid tumours informs therapeutic sensitivity. We demonstrate that spatial characteristics of oncogenic signalling and therapy response can be modelled in precision-cut slices fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f65017437957ddde284d19983379b3d4
https://doi.org/10.1002/path.5059

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Tumor heterogeneity, aggressiveness, and immune cell composition in a novel syngeneic PSA-targeted Pten knockout mouse prostate cancer (MuCaP) model

Autor: Petra W van Duijn, Cor A. Berrevoets, Angelique C.J. Ziel-van der Made, Ashraf Aghai, Wytske M. van Weerden, Guido Jenster, Rute B. Marques, Jan Trapman, Reno Debets, Hanneke J. A. A. van Zoggel

Publikováno v: Prostate, 78(13), 1013-1023. Wiley-Liss Inc.

Background Prostate cancer is recognized as a heterogeneous disease demanding appropriate preclinical models that reflect tumor complexity. Previously, we established the PSA-Cre;PtenLoxP/LoxP genetic engineered mouse model (GEMM) for prostate cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1aa427d28d0ad67f423dd911ea02dd6
https://doi.org/10.1002/pros.23659

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Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours

Publikováno v: Journal of Pathology, 245(1), 101-113. John Wiley & Sons Ltd.
The Journal of Pathology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f766be33f2ab7f68d5121725cb9d845
http://hdl.handle.net/10138/333759

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MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients

Autor: Cornelis F. M. Sier, W. van Duijn, Lukas J. A. C. Hawinkels, James C. H. Hardwick, Alexandra M. J. Langers, F.J.G.M. Kubben, H. W. Verspaget, Daan W. Hommes, J. J. van der Reijden

Publikováno v: British Journal of Cancer, 106(9), 1495-1498
British Journal of Cancer

Background: Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. Methods: We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18840b661106cc6da0f645072890aa14
https://doi.org/10.1038/bjc.2012.80

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Akademický článek

Recent Advances in Targeted Management of Inflammation In Atherosclerosis: A Narrative Review.

Autor: Zubirán, Rafael¹ (AUTHOR), Neufeld, Edward B.¹ (AUTHOR), Dasseux, Amaury¹ (AUTHOR), Remaley, Alan T.¹ (AUTHOR), Sorokin, Alexander V.^1,2,3 (AUTHOR) sorokinav2@nhlbi.nih.gov

Publikováno v: Cardiology & Therapy. Sep2024, Vol. 13 Issue 3, p465-491. 27p.

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MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not

Autor: Alexandra M. J. Langers, Daan W. Hommes, Lukas J. A. C. Hawinkels, Cornelis F. M. Sier, F.J.G.M. Kubben, J. J. van der Reijden, Hein W. Verspaget, W. van Duijn, Cornelis B.H.W. Lamers

Publikováno v: British Journal of Cancer

The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(-1306T) and high MMP-2 levels were significantly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea9a75208a901f63ff88cd61b0693f1
http://europepmc.org/articles/PMC2410128

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Increased mucosal matrix metalloproteinase-1, -2, -3 and -9 activity in patients with inflammatory bowel disease and the relation with Crohn's disease phenotype

Autor: Daan W. Hommes, W. van Duijn, Hein W. Verspaget, R. A. van Hogezand, A.M. van der Zon, Marij A C Mieremet-Ooms, Cornelis F. M. Sier, Cornelis B.H.W. Lamers, M.J.W. Meijer

Publikováno v: Digestive and Liver Disease. 39:733-739

Background and objective Matrix metalloproteinases are associated with matrix turnover in both physiological and pathological conditions. We postulate an association between aberrant matrix metalloproteinases proteolytic activity and the intestinal t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f614aad8e822c640cf899ac09a4a20
https://doi.org/10.1016/j.dld.2007.05.010

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Tissue level, activation and cellular localisation of TGF-β1 and association with survival in gastric cancer patients

Autor: W. van Duijn, F.J.G.M. Kubben, Kim Zuidwijk, Lukas J. A. C. Hawinkels, Hein W. Verspaget, Jan H. Verheijen, Cornelis B.H.W. Lamers, J. M. Van Der Zon, Daan W. Hommes, Cornelis F. M. Sier

Publikováno v: British Journal of Cancer, 3, 97, 398-404
British Journal of Cancer

Transforming growth factor-beta1 (TGF-beta1), a tumour suppressing as well as tumour-promoting cytokine, is stored as an extracellular matrix-bound latent complex. We examined TGF-beta1 activation and localisation of TGF-beta1 activity in gastric can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b9ba36400f5849d45bd364f6893f35
https://doi.org/10.1038/sj.bjc.6603877

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