Zobrazeno 1 - 10
of 260
pro vyhledávání: '"W, Wakarchuk"'
Autor:
James Li, Laleh Solhi, Ethan D. Goddard-Borger, Yann Mathieu, Warren W. Wakarchuk, Stephen G. Withers, Harry Brumer
Publikováno v:
Biotechnology for Biofuels, Vol 14, Iss 1, Pp 1-19 (2021)
Abstract Background The discovery of lytic polysaccharide monooxygenases (LPMOs) has fundamentally changed our understanding of microbial lignocellulose degradation. Cellulomonas bacteria have a rich history of study due to their ability to degrade r
Externí odkaz:
https://doaj.org/article/af9bcdd6e3844bf0832020cee3bde300
Autor:
Andreas Geissner, Lars Baumann, Thomas J. Morley, Andrew K. O. Wong, Lyann Sim, Jamie R. Rich, Pauline P. L. So, Edie M. Dullaghan, Etienne Lessard, Umar Iqbal, Maria Moreno, Warren W. Wakarchuk, Stephen G. Withers
Publikováno v:
ACS Central Science, Vol 7, Iss 2, Pp 345-354 (2021)
Externí odkaz:
https://doaj.org/article/8f8cb4dde1d84b6297a419a849de0783
Publikováno v:
Glycobiology. 32:429-440
The prospect of producing human-like glycoproteins in bacteria is becoming attractive as an alternative to already-established but costly mammalian cell expression systems. We previously described an Escherichia coli expression platform that uses a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957277e08b94178abd06580fc4d23ce7
https://doi.org/10.1093/glycob/cwab130
https://doi.org/10.1093/glycob/cwab130
Autor:
Duong T Bui, John S. Klassen, Elena N. Kitova, Pavel I. Kitov, Kelley W. Moremen, Matthew S. Macauley, Zhixiong Li, Lara K. Mahal, Warren W. Wakarchuk
Publikováno v:
Anal Chem
Carbohydrate-active enzymes (CAZymes) play critical roles in diverse physiological and pathophysiological processes and are important for a wide range of biotechnology applications. Kinetic measurements offer insight into the activity and substrate s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6eb425e4d8acb1d9ced5de9c866f451
https://doi.org/10.1021/acs.analchem.1c02089
https://doi.org/10.1021/acs.analchem.1c02089
Publikováno v:
Biochemical Journal. 478:3527-3537
We have been developing bacterial expression systems for human mucin-type O-glycosylation on therapeutic proteins, which is initiated by the addition of α-linked GalNAc to serine or threonine residues by enzymes in the GT-27 family of glycosyltransf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed28961a0ce8f778e66494c9504819d
https://doi.org/10.1042/bcj20210382
https://doi.org/10.1042/bcj20210382
Autor:
James Li, Ethan D. Goddard-Borger, Olanrewaju Raji, Hirak Saxena, Laleh Solhi, Yann Mathieu, Emma R. Master, Warren W. Wakarchuk, Harry Brumer
Publikováno v:
Appl Environ Microbiol
Cellulomonas flavigena is a saprotrophic bacterium that encodes, within its genome, four predicted lytic polysaccharide monooxygenases (LPMOs) from Auxiliary Activity family 10 (AA10). We showed previously that three of these cleave the plant polysac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6dce5661232fecf93aa417d3ee8276
https://europepmc.org/articles/PMC9361826/
https://europepmc.org/articles/PMC9361826/
Autor:
Lyann Sim, Pauline P L So, Edie M Dullaghan, Jamie R. Rich, Stephen G. Withers, Warren W. Wakarchuk, Lars Baumann, Andrew K O Wong, Etienne Lessard, Maria J. Moreno, Umar Iqbal, Andreas Geissner, Thomas J. Morley
Publikováno v:
ACS Central Science, Vol 7, Iss 2, Pp 345-354 (2021)
ACS Central Science
ACS Central Science
The maintenance of therapeutic glycoproteins within the circulatory system is associated, in large part, with the integrity of sialic acids as terminal sugars on the glycans. Glycoprotein desialylation, either by spontaneous cleavage or through host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9978a3a3ced2fe886c6ae93aeaf7856
https://doi.org/10.1021/acscentsci.0c01589
https://doi.org/10.1021/acscentsci.0c01589
Autor:
Sadia Rahmani, Hafsa Ahmed, Osemudiamen Ibazebo, Eden Fussner-Dupas, Warren W. Wakarchuk, Costin N. Antonescu
Clathrin-mediated endocytosis (CME) controls the internalization and function of a wide range of cell surface proteins. CME occurs by the assembly of clathrin and many other proteins on the inner leaflet of the plasma membrane into clathrin-coated pi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acf3015252d9ed72ceed75b890d8c187
https://doi.org/10.1101/2022.06.17.496621
https://doi.org/10.1101/2022.06.17.496621
Autor:
Warren W Wakarchuk, Denis Brochu, Simon Foote, Anna Robotham, Hirak Saxena, Tamara Erak, John Kelly
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151186 (2016)
The bacteria in the genus Cellulomonas are known for their ability to degrade plant cell wall biomass. Cellulomonas fimi ATCC 484 and C. flavigena ATCC 482 have been the subject of much research into secreted cellulases and hemicellulases. Recently t
Externí odkaz:
https://doaj.org/article/2fb1e21922f94dd6bd9f96060cb4d340
Autor:
Sai Priya Anand, Rebecca Pastora, M A Martin, P. Mark Hogarth, Jonathan Richard, Dennis R. Burton, Shilei Ding, David T. Evans, Lars Hangartner, Michael D. McLean, Jérémie Prévost, Warren W. Wakarchuk, William D. Tolbert, Gabrielle Gendron-Lepage, Haifeng Wang, Marzena Pazgier, Hwi Min Gil, Andrés Finzi, Wing-Fai Cheung, George M. Shaw, Halima Medjahed, Hirak Saxena, Bruce D. Wines, Doug Cossar
Publikováno v:
J Virol
The activity of broadly neutralizing antibodies (bNAbs) targeting HIV-1 depends on pleiotropic functions, including viral neutralization and the elimination of HIV-1-infected cells. Several in vivo studies have suggested that passive administration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3aa0e52b542e49516679150a9d89da
https://doi.org/10.1128/jvi.00796-21
https://doi.org/10.1128/jvi.00796-21