Výsledky vyhledávání - "W, Van Leeuwen"

Akademický článek

Altered ubiquitin signaling induces Alzheimer’s disease-like hallmarks in a three-dimensional human neural cell culture model

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Alzheimer’s disease (AD) is characterized by toxic protein accumulation in the brain. Ubiquitination is essential for protein clearance in cells, making altered ubiquitin signaling crucial in AD development. A defective variant, ubiquitin

Externí odkaz: https://doaj.org/article/74e57d7f81c342d092153d856a153d11

Zobrazit plný text záznamu

Psychological distress modulates dorsal anterior cingulate cortex responses to salient stimuli in obsessive-compulsive disorder

Autor: W. van Leeuwen, A. van der Straten, S.A. Bögemann, D. Denys, H. van Marle, G. van Wingen

Publikováno v: Journal of Affective Disorders, 325, 185-193
van Leeuwen, W, van der Straten, A, Bögemann, S A, Denys, D, van Marle, H & van Wingen, G 2023, ' Psychological distress modulates dorsal anterior cingulate cortex responses to salient stimuli in obsessive-compulsive disorder ', Journal of Affective Disorders, vol. 325, pp. 185-193 . https://doi.org/10.1016/j.jad.2022.12.145
Journal of Affective Disorders, 325, 185-193. Elsevier
Journal of affective disorders, 325, 185-193. Elsevier
Journal of Affective Disorders, 325, pp. 185-193

Background: Patients with obsessive-compulsive disorder (OCD) experience an exacerbation of symptoms under psychological distress. The neurobiological underpinnings of this effect of stress remain elusive. Here, we induced psychological distress to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86f7328e97920a881095a97863fc5a9
http://www.scopus.com/inward/record.url?scp=85146075266&partnerID=8YFLogxK

Zobrazit plný text záznamu

Akademický článek

Host-cell DNA methylation patterns during high-risk HPV-induced carcinogenesis reveal a heterogeneous nature of cervical pre-cancer

Autor: Wina Verlaat, Robert W. Van Leeuwen, Putri W. Novianti, Ed Schuuring, Chris J. L. M. Meijer, Ate G. J. Van Der Zee, Peter J. F. Snijders, Daniëlle A. M. Heideman, Renske D. M. Steenbergen, G. Bea A. Wisman

Publikováno v: Epigenetics, Vol 13, Iss 7, Pp 769-778 (2018)

Cervical cancer development following a persistent infection with high-risk human papillomavirus (hrHPV) is driven by additional host-cell changes, such as altered DNA methylation. In previous studies, we have identified 12 methylated host genes asso

Externí odkaz: https://doaj.org/article/575a5320a27447d395adaf3cea223c0e

Zobrazit plný text záznamu

Akademický článek

Effects of clopidogrel therapy on whole blood platelet aggregation, the Plateletworks® assay and coagulation parameters in cats with asymptomatic hypertrophic cardiomyopathy: a pilot study

Autor: M. L. den Toom, M. W. van Leeuwen, V. Szatmári, E. Teske

Publikováno v: Veterinary Quarterly, Vol 37, Iss 1, Pp 8-15 (2017)

Background: Although scientific evidence is limited, clopidogrel is frequently used as prophylaxis for arterial thromboembolism in cats with hypertrophic cardiomyopathy (HCM). Objectives: Evaluating effects of clopidogrel therapy in asymptomatic cats

Externí odkaz: https://doaj.org/article/c35dc25207f046bb8cda14d144642174

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Deposition of mutant ubiquitin in parkinsonism–dementia complex of Guam

Autor: Bert M. Verheijen, Tomoyo Hashimoto, Kiyomitsu Oyanagi, Fred W. van Leeuwen

Publikováno v: Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-3 (2017)

Externí odkaz: https://doaj.org/article/600bdfdaef494572b0a8e94d9727c8e7

Zobrazit plný text záznamu

Akademický článek

Dysfunction of Protein Quality Control in Parkinsonism–Dementia Complex of Guam

Autor: Bert M. Verheijen, Kiyomitsu Oyanagi, Fred W. van Leeuwen

Publikováno v: Frontiers in Neurology, Vol 9 (2018)

Guam parkinsonism–dementia complex (G-PDC) is an enigmatic neurodegenerative disease that is endemic to the Pacific island of Guam. G-PDC patients are clinically characterized by progressive cognitive impairment and parkinsonism. Neuropathologicall

Externí odkaz: https://doaj.org/article/0a291663a58f479fae9bae4fd6ac6a9e

Zobrazit plný text záznamu

Akademický článek

Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin

Autor: Ralf J. Braun, Cornelia Sommer, Christine Leibiger, Romina J.G. Gentier, Verónica I. Dumit, Katrin Paduch, Tobias Eisenberg, Lukas Habernig, Gert Trausinger, Christoph Magnes, Thomas Pieber, Frank Sinner, Jörn Dengjel, Fred W. van Leeuwen, Guido Kroemer, Frank Madeo

Publikováno v: Cell Reports, Vol 10, Iss 9, Pp 1557-1571 (2015)

Neuronal accumulation of UBB+1, a frameshift variant of ubiquitin B, is a hallmark of Alzheimer’s disease (AD). How UBB+1 contributes to neuronal dysfunction remains elusive. Here, we show that in brain regions of AD patients with neurofibrillary t

Externí odkaz: https://doaj.org/article/82827895d6f54a068f30299b67cf92a1

Zobrazit plný text záznamu

Influence of esomeprazole on the bioavailability of afatinib

Autor: G.D. Marijn Veerman, Daan P. Hurkmans, Marthe S. Paats, Esther Oomen-de Hoop, Cor H. van der Leest, Eric R.E. van Thiel, Joachim G.J.V. Aerts, Roelof W. van Leeuwen, Anne-Marie C. Dingemans, Ron H.J. Mathijssen

Publikováno v: Biomedicine and Pharmacotherapy, 155:113695. Elsevier Masson

Afatinib is an oral small-molecule kinase inhibitor (SMKI) approved for treatment of metastatic non-small cell lung cancer (NSCLC) with an epidermal growth factor receptor (EGFR) driver mutation. Although oral administration is convenient, most SMKIs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5e235dc4931fdbeeb62aeaa4cc6504
https://doi.org/10.1016/j.biopha.2022.113695

Zobrazit plný text záznamu

Akademický článek

Commentary: The landscape of transcription errors in eukaryotic cells

Autor: Bert M. Verheijen, Fred W. van Leeuwen

Publikováno v: Frontiers in Genetics, Vol 8 (2017)

Externí odkaz: https://doaj.org/article/01b8dd0f6da144048e1eb0fbb32ab246

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání