Zobrazeno 1 - 10
of 973
pro vyhledávání: '"W, Schunack"'
Autor:
W. Schunack
Publikováno v:
Alimentary Pharmacology & Therapeutics. 1:493s-503s
The H2-receptor antagonists which are used for ulcer therapy fall into four main structural classes. Cimetidine is an imidazole derivative; ranitidine belongs to the basically substituted furans, famotidine is a member of the guanidinothiazole group;
Autor:
C. Robin Ganellin, Heinz H. Pertz, Michael Krause, Holger Stark, Schwartz Jc, A Huls, X Ligneau, Jean-Michel Batiment Arrang, W Schunack, Galina Meier
Publikováno v:
Journal of Medicinal Chemistry. 47:2678-2687
In an effort to develop new histamine H(3) receptor antagonists usable as pharmacological tools we present here novel unsymmetrical ether derivatives. Etherification of different omega-(1H-imidazol-4-yl)alkyl scaffolds led to compounds containing alk
Publikováno v:
Pharmacy World and Science. 21:184-189
The optimum dose of calcium folinate (leucovorin) as modulator of fluorouracil has not been defined yet. We conducted a randomized trial to compare the pharmacokinetics/pharmacodynamics of two doses of calcium folinate. 16 patients with advanced colo
Publikováno v:
Clinical Pharmacology & Therapeutics. 58:532-541
Objective Probenecid-sensitive anion transport systems may be involved in distribution and elimination processes of anionic drugs. The aim of this study was to determine the effect of multiple probenecid treatment on the pharmacokinetic disposition o
Autor:
W Schunack, Rainer Harhammer, Roland Seifert, A. Hagelüken, Lore Grünbaum, Bernd Nürnberg, Günter Schultz, Christian Leschke, Jan F. Klinker
Publikováno v:
Biochemical Pharmacology. 49:901-914
In dibutyryl cAMP-differentiated human leukemia (HL-60) cells, the potent histamine H1-receptor agonist, 2-(3-chlorophenyl)histamine, activates pertussis toxin (PTX)-sensitive guanine nucleotide-binding proteins (G-proteins) of the Gi-subfamily by a
Autor:
M. C. Nahata, J. L. Bootman, Z. Zadák, P. B. Soeters, Laurence A. Goldberg, S. Stremetzne, U. Jaehde, M. Streit, E. D. Kreuser, E. Thiel, W. Schunack, R. T. Calvert, M. Feely, H. Chrystyn, M. A. Mangues, G. Ginovart, M. A. Moral, A. P. Lopes, R. Farré, X. Demestre, O. Altirriba, Ch. Kloft, J. Beyer, J. Steuer, W. Siegert, J. Bever, M. Bialer, S. Sussan, O. Abu Salach, H. D. Danenberg, A. Laor, M. I. Barnett, A. G. Cosslett, J. Cohen, P. Marini, C. Bassi, A. Bonzanini, T. Cassani, G. Ore, G. Mangiante, G. Scroccaro, M. Kaczan, J. Eriksen, B. Toft, M. Jandová, J. Vlček, V. Klemerová, L. Sobotka, A. Ayestarán, R. López, J. B. Montoro, L. Pou, A. Estíbalez, B. Pascual, M. D. Aumente, M. D. Panadero, M. Caraballo, J. C. Pozo, J. L. Perez, A. C. Falcão, M. M. Fernández de Gatta, A. Dominguez-Gil, M. M. Caramona, J. M. Lanao, Z. Fendrich, J. Zajic, Medall M. D. Bellés, Alós V. G. Casabó, Torres N. V. Jiménez, Botella M. A. Hervás, Gimeno F. J. Abad, Melchor D. E. Casterá, M. Aminian, A. Clopés, C. Branco, I. Badell, N. Pardo, C. Palací, J. Bonal, G. Rialp, B. Bara, M. Nobilis, V. Bláha, E. Havel, J. Květina, M. Brátová, D. Solichová, M. Mullerova, D. Svoboda, M. Pokrajac, B. Miljković, D. Simić, B. Brzaković, A. Galetin, R. L. Pinheiro, A. P. Carrondo, E. Sieradzki, K. Strauss, E. Olejarz, A. Marzec, J. Kaużny, J. Szymura-Oleksiak, E. Wyska, B. Jarosz, I. Kosowicz, K. Fabirkiewicz, R. Cherian, A. -L. Vodoz, B. Imsand, D. Belli, Th. Rochat, H. Müllerová, F. Falcão, A. Carvalho, T. Pereira, C. Fonseca, O. Freitas, M. Resende, A. Parrinha, M. Costa, M. A. Pessanha, A. Ferreira, L. Mourão, F. Ceia, Mendonça Lima, R. Tavares, A. SalesLuis, Santos Carlos, M. E. Araújo Pereira, J. Alves do Carmo, J. M. Forjaz Lacerda, J. A. Morais, C. Beaufils, M. Duff, P. Zamparutti, P. Assicot, M. Bohor, B. Angelini, M. Lambert, J. C. Manelli, A. Gayte-Sorbier, M. C. Bongrand, P. Timon-David, I. C. Fiqueira, R. Lourenco, P. A. Silva, M. O. Rodrigues, A. Fischer, W. Schorr, R. Radziwill, M. Lihtamo, A. Jäppinen, K. Tuovinen, M. Pekkala, L. Nuutinen, L. Morató, L. Lorente, J. Muñoz, Ph Monges, A. Blancard, B. Lacarelle, J. P. Denis, M. -C. Bongrand, Ch Penot-Ragon, F. Gouin, Nicole Petitcollot, I. Tinguely, J. Beney, S. Marty, J. -Ph. Reymond, J. Bussels, H. Robays, A. Litzinger, R. Rohda-Bohler, M. S. Salek, S. Turpin, E. Derby, B. Millar, C. Maggs, L. M. Santiago, Marques Batel, G. Cajaraville, M. J. Tarnés, M. J. Díaz, C. Pozo, A. Plazaola, M. Vuelta, E. Díaz-Munío, A. Ferrer, A. Lozano, R. Guerra, J. L. Pontón, K. Kint, A. Verstraetep, D. El Eini, R. K. Ojala, K. M. Kontra, T. J. P. Naaranlahti, M. Martorell, M. Oliveras, C. Juste, M. T. Lopez, E. Hidalgo, M. J. Cabañas, C. Barroso, J. M. Llop, M. Rey, E. Diaz-Munio, L. Pastó, M. Tubau, M. J. Gómez-Bellver, J. Rodriguez, J. M. Gómez, M. L. Gónzalez, V. Gol, V. Fuentes, S. Ramón, L. Girona, T. Castelló, M. Olona, L. García, C. Girón, C. Monteserín, P. Gonzalez, C. Alberola, J. A. L. Feio, D. Pharm, F. J. Batel Marques, Alexandrino M. Borges, S. Salek, M. C. Escoms, I. Caro, N. Ticó, M. Hidalgo, R. Bruguera, R. Jodar, J. M. Dowell, P. G. Davey, M. Malek, M. Rev, I. Ferrer, T. Marti, M. Ibars, J. P. Delporte, M. Ansseau, A. Albert, M. Sibourg, O. Gaspard, M. Deprez, H. M. Ndougsa, M. Poma, M. J. Tamés, K. Macek, M. Klejna, S. Dhillon, I. Castro, M. Newton, I. A. Zupanets, V. P. Chernyh, N. B. Bezdetko, S. B. Popov, M. N. Velieva, S. M. Babajeya, Y. D. Mamedov, Y. Dj. Mammedov, P. M. Veliev, A. A. Nasudari, A. A. Bandalieva, S. Nordbo, M. Smith-Solbakken, R. Myklctun, W. Berge, M. Thormodsen, L. A. Zupanets, L. S. Kicenko, S. I. Plusch, S. G. Isaev, L. Vokrouhlický, R. Souček, P. Kuneš, O. Nývlt, L. A. Potselueva, S. N. Egorova, E. A. Kadirova, L. E. Ziganshina, J. Chaloupka, K. Genger
Publikováno v:
Pharmacy World & Science
Publikováno v:
European Journal of Medicinal Chemistry. 30:219-225
Summary In search for potential histamine H3-receptor agonists a series of mono- and dialkyl-substituted histamine derivatives was synthesized. All target compounds were tested in vitro for their agonist activity at H3-, H2-, and H1-receptors. Introd
Publikováno v:
European Journal of Medicinal Chemistry. 30:271-276
Summary The cationic-amphiphilic 2-substituted histamines, 2-(3-chlorophenyl)histamine (2-[2-(3-chlorophenyl)-1H-imidazol-4-yl]ethanamine) and 2-(2-cyclohexylethyl)histamine, activate pertussis toxin-sensitive guanine nucleotide-binding proteins (G-p
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:1129-1133
The effects of an antacid containing magnesium and aluminum hydroxide on the pharmacokinetics of pefloxacin in 10 healthy volunteers were investigated. In a randomized crossover design, each subject received an oral dose of 400 mg of pefloxacin eithe