Conditional Deletion of Pdcd1 Identifies the Cell-Intrinsic Action of PD-1 on Functional CD8 T Cell Subsets for Antitumor Efficacy

Autor: Sukanya Raghavan, Nataliya Tovbis-Shifrin, Christina Kochel, Anandi Sawant, Marielle Mello, Manjiri Sathe, Wendy Blumenschein, Eric S. Muise, Alissa Chackerian, Elaine M. Pinheiro, Thomas W. Rosahl, Hervé Luche, Rene de Waal Malefyt

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Programmed cell death-1 (PD-1) blockade has a profound effect on the ability of the immune system to eliminate tumors, but many questions remain about the cell types involved and the underlying mechanisms of immune activation. To shed some light on t

Externí odkaz: https://doaj.org/article/72fd7ab5d05749e780b38e08a7d4a277

Effective Anti-tumor Response by TIGIT Blockade Associated With FcγR Engagement and Myeloid Cell Activation

Autor: Jin-Hwan Han, Mingmei Cai, Jeffery Grein, Samanthi Perera, Hongmei Wang, Mike Bigler, Roenna Ueda, Thomas W. Rosahl, Elaine Pinheiro, Drake LaFace, Wolfgang Seghezzi, Sybil M. Genther Williams

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

The molecule “T cell immunoreceptor with immunoglobulin and ITIM domain,” or TIGIT, has recently received much attention as a promising target in the treatment of various malignancies. In spite of the quick progression of anti-TIGIT antibodies in

Externí odkaz: https://doaj.org/article/95ab8cf9ccb34b67a1feb2cd6810ed2c

Loss of low-molecular-weight protein tyrosine phosphatase shows limited improvement in glucose tolerance but causes mild cardiac hypertrophy in mice

Autor: Sharon, Jensen-Cody, Erin S, Coyne, Xunshan, Ding, Anu, Sebin, Jen, Vogel, Jaclyn, Goldstein, Thomas W, Rosahl, Heather H, Zhou, Hugues, Jacobs, Marie-France, Champy, Ghina Bou, About, Saswata, Talukdar, Yingjiang, Zhou

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 322:E517-E527

Insulin resistance is a major public health burden that often results in other comorbidities including type 2 diabetes, nonalcoholic fatty liver disease (NAFLD), and cardiovascular disease. An insulin sensitizer has the potential to become a disease-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b12db4b6eb905c97891845c18f73eb
https://doi.org/10.1152/ajpendo.00161.2021

High Resolution Episcopic Microscopy for Qualitative and Quantitative Data in Phenotyping Altered Embryos and Adult Mice Using the New 'Histo3D' System

Autor: James Mu, Thomas W. Rosahl, Didier Hentsch, Serge Taubert, Manuel Mark, Fabien Pertuy, Michela Di Michele, Jean-Luc Vonesch, Olivia Wendling, Hugues Jacobs, Laurent Le Cam, Nicolas Lemercier, Yann Herault, Tania Sorg, Mindy Liu, Ester Carballo-Jane

Publikováno v: Biomedicines, Vol 9, Iss 767, p 767 (2021)
Biomedicines
Volume 9
Issue 7
Biomedicines, 2021, 9 (7), pp.767. ⟨10.3390/biomedicines9070767⟩
Biomedicines, MDPI, 2021, 9 (7), pp.767. ⟨10.3390/biomedicines9070767⟩

International audience; 3D imaging in animal models, during development or in adults, facilitates the identification of structural morphological changes that cannot be achieved with traditional 2D histological staining. Through the reconstruction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ae7d93fc41d5226b253cefc0661e69
https://www.mdpi.com/2227-9059/9/7/767

C57BL6 mouse substrains demonstrate differences in susceptibility to the demyelinating effects of Cuprizone toxin

Autor: Anna-Mari Karkkainen, Philip Manfre, Elaine O’Loughlin, Juha Kuosmanen, Gonzalo Zeballos Zeballos, Kimmo Lehtimäki, Binod Jacob, Takayuki Tsuchiya, Geoffrey B. Varty, Matthew E. Kennedy, Nicholas T Gatto, Thomas W. Rosahl, Sophia Bardehle, Christian Mirescu, Anjali McCullough

Advances in our understanding of cellular functions and phenotypes in the brain rely on technically robust experimental in vivo models with face validity towards human disease. The cuprizone toxin-induced demyelination model is widely used to investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26d07f472de9c117ab0bb2ba15fbe88e
https://doi.org/10.1101/2020.12.17.423334