Hepatitis B core related antigen in relation to intrahepatic and circulating viral markers, before and after combination therapy

Autor: Robin Erken, Hans L. Zaaijer, Sophie B. Willemse, Ed Bakker, Bart B. Takkenberg, Henk W. Reesink, Neeltje A. Kootstra

Publikováno v: Annals of Hepatology, Vol 26, Iss , Pp 100540- (2021)

Introduction and Objectives: Covalently closed circular (ccc)DNA acts as a viral reservoir in the liver of patients with a chronic hepatitis B (CHB) infection and can only be quantified in liver biopsies. Hepatitis B core-related antigen (HBcrAg) lev

Externí odkaz: https://doaj.org/article/4e448280b0504405aab18d7435ed65bd

Human intrahepatic CD69 + CD8+ T cells have a tissue resident memory T cell phenotype with reduced cytolytic capacity

Autor: Femke Stelma, Annikki de Niet, Marjan J. Sinnige, Karel A. van Dort, Klaas P. J. M. van Gisbergen, Joanne Verheij, Ester M. M. van Leeuwen, Neeltje A. Kootstra, Hendrik W. Reesink

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Abstract Tissue resident memory T cells (TRM) have been identified in various tissues, however human liver TRM to date remain unidentified. TRM can be recognized by CD69 and/or CD103 expression and may play a role in the pathology of chronic hepatiti

Externí odkaz: https://doaj.org/article/b56880598d574792ab00d0e87c2e8df7

Reply

Autor: Vladimir Loukachov, Karel van Dort, Robin Erken, Henk W. Reesink, Neeltje Kootstra

Publikováno v: Hepatology. John Wiley and Sons Ltd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8494d1cd0010705d5d09df980e3c517f
https://pubmed.ncbi.nlm.nih.gov/35809235

Long-term follow-up of patients treated with entecavir and peginterferon add-on therapy for HBeAg-positive chronic hepatitis B infection: ARES long-term follow-up

Autor: Xun Qi, Adrian Streinu-Cercel, Heng Chi, Fehmi Tabak, Qing Xie, Mircea Diculescu, Margo J. H. van Campenhout, Elke Verhey, Harry L.A. Janssen, Willem P. Brouwer, Bettina E. Hansen, Hendrik W. Reesink, Włodzimierz Mazur, Rob J. de Knegt, Krzysztof Simon, Ningping Zhang, Meral Akdogan, J. Wang, S. Guo, Ramazan Idilman

Publikováno v: Journal of viral hepatitis, 26(1), 109-117. Wiley-Blackwell
Journal of Viral Hepatitis, 26(1), 109-117. Wiley-Blackwell Publishing Ltd

Addition of peginterferon alpha (PEG-IFN add-on) to entecavir (ETV) treatment after a short lead-in phase results in more response than ETV monotherapy in HBeAg-positive chronic hepatitis B infection (CHB). This study is the first to assess long-term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2add2b6196a6377758f5b7c0a3a713e1
https://doi.org/10.1111/jvh.12997

Deep sequencing identifies hepatitis B virus core protein signatures in chronic hepatitis B patients

Autor: Matthijs R.A. Welkers, Meike H. van der Ree, Hendrik W. Reesink, K. Anton Feenstra, Louis Jansen, Neeltje A. Kootstra

Publikováno v: Antiviral research, 158, 213-225. Elsevier
van der Ree, M H, Jansen, L, Welkers, M R A, Reesink, H W, Feenstra, K A & Kootstra, N A 2018, ' Deep sequencing identifies hepatitis B virus core protein signatures in chronic hepatitis B patients ', Antiviral research, vol. 158, pp. 213-225 . https://doi.org/10.1016/j.antiviral.2018.08.009

BACKGROUND: We aimed to identify HBc amino acid differences between subgroups of chronic hepatitis B (CHB) patients.METHODS: Deep sequencing of HBc was performed in samples of 89 CHB patients (42 HBeAg positive, 47 HBeAg negative). Amino acid types w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349656252b90cc2f59939583764c907e
http://www.scopus.com/inward/record.url?scp=85052436093&partnerID=8YFLogxK