Zobrazeno 1 - 10
of 36
pro vyhledávání: '"W, Petko"'
Autor:
Fernando Camacho, Fink David M, Olsen Gordon Edward, Lawrence L. Martin, Wayne W. Petko, Richard C. Effland, Hugo M. Vargas, Craig P. Smith, David E. Selk, Douglas K. Rush, Klein Joseph Thomas, Peter Allen Nemoto, Larry Davis, Gina M. Bores, James T. Winslow
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:157-162
A series of carbamate analogs of besipirdine (HP 749) was synthesized as potential agents with enhanced cholinomimetic properties for the treatment of Alzheimer's disease. Compound 5a (P10358, 1-[3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a6f4a2e14f8942baf3115f4bd52456a
https://doi.org/10.1016/s0960-894x(96)00592-6
https://doi.org/10.1016/s0960-894x(96)00592-6
Autor:
Roy Corbett, Wayne W. Petko, Gina M. Bores, Ann T. Woods-Kettelberger, Sathapana Kongsamut, Craig P. Smith, Joachim E. Roehr, Susan M. Chesson
Publikováno v:
Neurochemical Research. 21:575-583
Examination of HP 184, [N-n-propyl)-N-(3-fluoro-4-pyridinyl) -1H-3-methylindodel-1-amine hydrochloride], in a variety of tests for serotonergic activity revealed some unique properties of this compound. We report here that 100 microM HP 184 enhanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b213d4ae8d16fe74ee9237f46982fd62
https://doi.org/10.1007/bf02527756
https://doi.org/10.1007/bf02527756
Autor:
Kurys Barbara E, Michael C. Merriman, Olsen Gordon Edward, Fink David M, Mark G. Palermo, Francis P. Huger, Gina M. Bores, Wayne W. Petko, Gerard J. O'Malley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:625-630
A series of imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates was prepared and evaluated as dual acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitors. Halogen substitution ortho to the carbamate functionality in the eight position r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::028dcf8fee9ea564376729116d03aa6f
https://doi.org/10.1016/0960-894x(96)00072-8
https://doi.org/10.1016/0960-894x(96)00072-8
Autor:
Craig P. Smith, Kevin J. Kapples, Michael Cornfeldt, Olsen Gordon Edward, Richard C. Effland, Wayne W. Petko, Klein Joseph Thomas, Francis P. Huger, Larry Davis
Publikováno v:
Journal of Medicinal Chemistry. 39:582-587
A novel series of substituted (pyrroloamino)pyridines was synthesized, and the compounds were evaluated for cholinomimetic-like properties in vitro (inhibition of [3H]quinuclidinyl benzilate binding) and in vivo (reversal of scopolamine-induced demen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0552535476f4fd36fc8fa0943dd818a
https://doi.org/10.1021/jm950644v
https://doi.org/10.1021/jm950644v
Autor:
Richard C. Effland, Craig P. Smith, Joseph Thomas Klein, Joachim E. Roehr, Sathapana Kongsamut, Wayne W. Petko, Francis P. Huger
Publikováno v:
Drug Development Research. 32:13-18
N-(n-propyl)-N-(4-pyridinyl)-1H-indol-1-amine (HP 749) is currently in clinical trials for the treatment of Alzheimer's disease (AD). While HP 749 has many pharmacological properties, the biochemical basis for its efficacy in animal models for AD rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3713eb419a4c12a5880dfd4177b7e0c6
https://doi.org/10.1002/ddr.430320104
https://doi.org/10.1002/ddr.430320104
Autor:
Craig P. Smith, Kevin J. Kapples, Olsen Gordon Edward, Wayne W. Petko, Klein Joseph Thomas, Michael Cornfeldt, Larry Davis, Richard C. Effland, Francis P. Huger
Publikováno v:
ChemInform. 27
A novel series of substituted (pyrroloamino)pyridines was synthesized, and the compounds were evaluated for cholinomimetic-like properties in vitro (inhibition of [3H]quinuclidinyl benzilate binding) and in vivo (reversal of scopolamine-induced demen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c28831b45ce110dc816c604de4d750a
https://doi.org/10.1002/chin.199619156
https://doi.org/10.1002/chin.199619156
Autor:
J. C. Wilker, G. S. Wong, E. Landau, R. D. Blitzer, Richard C. Effland, Lawrence L. Martin, Vahram Haroutunian, Larry Davis, Craig P. Smith, Francis P. Huger, Klein Joseph Thomas, Olsen Gordon Edward, Wayne W. Petko, Michael Cornfeldt
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b533e948b72ee368d9e7f17ce799a988
https://doi.org/10.1002/chin.199619155
https://doi.org/10.1002/chin.199619155
Autor:
Klein Joseph Thomas, Craig P. Smith, Fink David M, Wayne W. Petko, Richard C. Effland, Douglas K. Rush, Peter Allen Nemoto, Fernando Camacho, Olsen Gordon Edward, Larry Davis, Gina M. Bores, James T. Winslow, David E. Selk, Hugo M. Vargas, Lawrence L. Martin
Publikováno v:
ChemInform. 28
A series of carbamate analogs of besipirdine (HP 749) was synthesized as potential agents with enhanced cholinomimetic properties for the treatment of Alzheimer's disease. Compound 5a (P10358, 1-[3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41000ba1c31656f9c84fb42e02ee999a
https://doi.org/10.1002/chin.199720130
https://doi.org/10.1002/chin.199720130
Autor:
C P, Smith, G M, Bores, W, Petko, M, Li, D E, Selk, D K, Rush, F, Camacho, J T, Winslow, R, Fishkin, D M, Cunningham, K M, Brooks, J, Roehr, H B, Hartman, L, Davis, H M, Vargas
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(2)
1-[(3-Fluoro-4-pyridinyl)amino]-3-methyl-1(H)-indol-5-yl methyl carbamate (P10358) is a potent, reversible acetylcholinesterase inhibitor that produces central cholinergic stimulation after oral and parental administration in rats and mice. P10358 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5341035c9e227d7dd84b87a3631a028e
https://pubmed.ncbi.nlm.nih.gov/9023283
https://pubmed.ncbi.nlm.nih.gov/9023283
Autor:
G M, Bores, F P, Huger, W, Petko, A E, Mutlib, F, Camacho, D K, Rush, D E, Selk, V, Wolf, R W, Kosley, L, Davis, H M, Vargas
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(2)
Acetylcholinesterase (AChE) inhibitors from several chemical classes have been tested for the symptomatic treatment of Alzheimer's disease; however, the therapeutic success of these compounds has been limited. Recently, another AChE inhibitor, galant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::adbfcdf2868fbefad406fd3f2a33a8ca
https://pubmed.ncbi.nlm.nih.gov/8627552
https://pubmed.ncbi.nlm.nih.gov/8627552