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ChemInform Abstract: Synthesis and Action on the Central Nervous System of Some N2- Substituted Cinnoline Derivatives

Autor: W. Pakulska, A. Szadowska, Stańczak A, Kwapiszewski W

Publikováno v: ChemInform. 25

Alkylation of 4-hydroxycinnolines using ethyl bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e60e04159f9165b70e92302f7732e71
https://doi.org/10.1002/chin.199443181

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ChemInform Abstract: Synthesis, Structures, and Biological Activity of Some 4-Amino-3-cinnolinecarboxylic Acid Derivatives

Autor: W. Pakulska, A. Stanczak

Publikováno v: ChemInform. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14ecaae82d9ffa05e760a37f18e30d9c
https://doi.org/10.1002/chin.199811172

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ChemInform Abstract: Synthesis and Biological Activity of Some 4-Amino-3-cinnoline Carboxylic Acid Derivatives. Part 4. 2,4-Dioxo-1,2,3,4-tetrahydropyrimido[5,4-c]cinnolines

Autor: W. Pakulska, Stańczak A, W. Lewgowd

Publikováno v: ChemInform. 29

A series of new 2,4-dioxo-1,2,3,4-tetrahydropyrimido[5,4-c]cinnolines and their 3-substituted derivatives were prepared. These compounds were obtained by cyclocondensation of the appropriate substituted 4-amino-3-cinnolinecarboxylic acid with urea or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b55328999cfde2de0dc83a6a028dfaa
https://doi.org/10.1002/chin.199832206

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ChemInform Abstract: Synthesis and Biological Activity of Some 4-Amino-3-cinnolinecarboxylic Acid Derivatives. Part 5. Pyrimido[5,4-c]cinnolines and Triazepino[7,6-c]cinnoline

Autor: Z. B. Ochocki, W. Pakulska, Andrzej Stańczak

Publikováno v: ChemInform. 30

A series of substituted 3-aminopyrimido[5,4-c]cinnolines 3, 7 was prepared. 6,7-Substituted 4-amino-3-cinnolinecarboxylic acid 1 were condensed with acetic anhydride to give the respective 1,3-oxazino[5,4-c]cinnolines 2. The obtained derivatives reac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64b35f8e364e30b9060d94a46fcc4b9f
https://doi.org/10.1002/chin.199913179

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Antitumor effect of Pt(II) amine phosphonate complexes on sarcoma sa-180 in mice. Crystal structure of cis-dichlorobis(diethyl-4-pyridylmethylphosphonate-kappaN)platinum(II) hydrate, cis-[PtCl2(4-pmpe)2].H20

Autor: K, Aranowska, J, Graczyk, L, Checińska, W, Pakulska, J, Ochock

Publikováno v: Die Pharmazie. 61(5)

The cisplatin analogoues platinum (II) complexes of the general formula cis-[PtL2Cl2], where L is monodentate diethyl 2-, 3- or 4-pyridylmethylphosphonate (2-, 3- or 4-pmpe) ligand, have been synthesized and characterized by means of IR and NMR (1H,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d28baac2efbc20aead8e5b2dfd6ffc2
https://pubmed.ncbi.nlm.nih.gov/16724546

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Influence of mianserin on the antinociceptive effect of morphine, metamizol and indomethacin in mice

Autor: W. Pakulska, E. Czarnecka

Publikováno v: Pharmacological research. 46(5)

The influence of mianserin (5 or 3.6 mg kg −1 ) on antinociceptive effect of morphine (10 mg kg −1 ), metamizol (500 mg kg −1 ) and indomethacin (10 or 1.4 mg kg −1 ) was investigated in a mouse model using the tail-flick and hot-plate tests.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0f73b54e2c18ef76575c1b17ca49a9
https://pubmed.ncbi.nlm.nih.gov/12419646

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Effect of citalopram and buspirone on the antinociceptive action of analgesic drugs

Autor: W, Pakulska, E, Czarnecka

Publikováno v: Acta poloniae pharmaceutica. 58(4)

The influence of citalopram (20 mg/kg i.p.) and buspirone (3 mg/kg i.p.) on analgesic effects of morphine (10 mg/kg i.p.), metamizole (500 mg/kg i.p.) and indomethacin (10 mg/kg) was studied with tail-flick and hot-plate tests on mice. The research s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f66e4077e3c0f8d764a4f25c2253f6a
https://pubmed.ncbi.nlm.nih.gov/11693737

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Comparison of pharmacophore cinnoline and quinoline systems on the basis of computer calculation and pharmacological screening of their condensed systems

Autor: A, Stańczak, W, Pakulska, B, Pietrzak, W, Lewgowd

Publikováno v: Die Pharmazie. 56(6)

A series of new pyrimido[5,4-c]quinoline derivatives were prepared to compare the pharmacophore systems of cinnoline and quinoline. These compounds were obtained by the cyclocondensation of appropriately substituted 4-amino-3-quinolinecarboxylic acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ee88f0905c494d73b78c23cfc158c35
https://pubmed.ncbi.nlm.nih.gov/11446173

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Synthesis and action on the central nervous system of 8-substituted 6,7,8,9-tetrahydro-5H-1,2,4-triazolo[4,3-a]-diazepine derivatives

Autor: R, Guryn, W, Pakulska, E, Brzezińska

Publikováno v: Acta poloniae pharmaceutica. 58(1)

Selected 8-substituted 6,7,8,9-tetrahydro-5H-1,2,4-triazolo[4,3-a] diazepine derivatives were synthesised and tested for their action on the central nervous system. The obtained results showed that the examined compounds type IV have sedative activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e871159ee5798aa5ccc5266d273bc976
https://pubmed.ncbi.nlm.nih.gov/11370288

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