Zobrazeno 1 - 10 of 165 pro vyhledávání: '"W, Northemann"'
2
Murine monoclonal glutamic acid decarboxylase (GAD)65 antibodies recognize autoimmune-associated GAD epitope regions targeted in patients with type 1 diabetes mellitus and Stiff-man syndrome
Autor: Michael Schlosser, W. Northemann, M. Strebelow, Manfred Ziegler, Alvin C. Powers, Ziegler B, P. Augstein, F. Lühder
Publikováno v: Acta Diabetologica. 33:225-231
To study the immune response to glutamic acid decarboxylase (GAD) in insulin-dependent diabetes mellitus, monoclonal GAD antibodies after fusion of splenocytes from a nondiabetes-susceptible BALB/c mouse immunized with human recombinant GAD65 were ge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d5a65bf913aa2fd5b04eb6540b1556
https://doi.org/10.1007/bf02048548
Zobrazit plný text záznamu
3
IL-6 functions as an exocrine hormone in inflammation. Hepatocytes undergoing acute phase responses require exogenous IL-6
Autor: J Gauldie, W Northemann, G H Fey
Publikováno v: The Journal of Immunology. 144:3804-3808
We have previously shown that IL-6 is the major monocyte- and fibroblast-derived regulator of acute phase protein gene expression and synthesis in hepatocytes in inflammation. Recently, we and others have shown that rat and human hepatoma cells expre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a761077c613fd31c71563fb5318edcf
https://doi.org/10.4049/jimmunol.144.10.3804
Zobrazit plný text záznamu
4
T cell lines recognizing the 70-kD protein of U1 small nuclear ribonucleoprotein (U1snRNP)
Autor: Guido Wolff-Vorbeck, S. Fenning, R. Lührmann, H. H. Peter, Michael Schlesier, W. Hackl, Ulrich Krawinkel, W. Northemann
SUMMARY In sera of patients with mixed connective tissue disease (MCTD) high titres of IgG autoantibodies to U1snRNP-specific proteins (70kD, A, C) are found, suggesting an antigen-driven and T cell-dependent process. In order to establish U1snRNP-sp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269bdb8f6539096ae1cb1bddc6f84b8d
https://europepmc.org/articles/PMC1553240/
Zobrazit plný text záznamu
5
Monoclonal antibodies specific to the glutamic acid decarboxylase 65 kDa isoform derived from a non-obese diabetic (NOD) mouse
Autor: B, Ziegler, P, Augstein, F, Lühder, W, Northemann, J, Hamann, M, Schlosser, I, Klöting, D, Michaelis, M, Ziegler
Publikováno v: Diabetes research (Edinburgh, Scotland). 25(2)
Two monoclonal antibodies specifically recognizing the 65 kDa isoform of the enzyme glutamic acid decarboxylase (GAD) were generated by fusion of spleen cells of a non-obese diabetic (NOD) mouse which had received a single intraperitoneal injection o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d35101694b0f97521d483e1aa4278b3
https://pubmed.ncbi.nlm.nih.gov/7544254
Zobrazit plný text záznamu
6
Baculovirus-mediated expression of human 65 kDa and 67 kDa glutamic acid decarboxylases in SF9 insect cells and their relevance in diagnosis of insulin-dependent diabetes mellitus
Autor: L, Mauch, J, Seissler, H, Haubruck, N J, Cook, C C, Abney, H, Berthold, C, Wirbelauer, B, Liedvogel, W A, Scherbaum, W, Northemann
Publikováno v: Journal of biochemistry. 113(6)
cDNAs coding for the full-length human 65 and 67 kDa glutamic acid decarboxylases (GAD65 and GAD67) were amplified from pancreas and hippocampus cDNA libraries by polymerase chain reaction, respectively. Both cDNAs were inserted into a baculovirus ve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03ce06bc730a247eaace30a4b9926cf2
https://pubmed.ncbi.nlm.nih.gov/8370667
Zobrazit plný text záznamu
7
Production of recombinant rat interleukin-6 in Escherichia coli using a novel highly efficient expression vector pGEX-3T
Autor: B, Frorath, C C, Abney, H, Berthold, M, Scanarini, W, Northemann
Publikováno v: BioTechniques. 12(4)
Interleukin-6 (IL-6) is one of the most important mediators of the acute phase reaction in liver. For the production of recombinant rat IL-6 in Escherichia coli, a previously isolated cDNA coding for the rat IL-6 was cloned into the modified novel ex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f5c77cb5610f10977ea8b2edafbb31cf
https://pubmed.ncbi.nlm.nih.gov/1503758
Zobrazit plný text záznamu
9
Identification of a glucocorticoid response element contributing to the constitutive expression of the rat liver alpha 1-inhibitor III gene
Autor: L J, Abraham, A D, Bradshaw, W, Northemann, G H, Fey
Publikováno v: The Journal of biological chemistry. 266(27)
alpha 1-Inhibitor III (alpha 1 I3), a broad range plasma proteinase inhibitor, is synthesized with striking tissue specificity in rat livers. The gene is expressed strongly in periportal hepatocytes of healthy adults and less abundantly in regions ne
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d53894301bd3e2b690dc1e779d4d08b4
https://pubmed.ncbi.nlm.nih.gov/1917955
Zobrazit plný text záznamu
10
Cloning and expression of antigenic epitopes of the human 68-kDa (U1) ribonucleoprotein antigen in Escherichia coli
Autor: B, Frorath, M, Scanarini, H J, Netter, C C, Abney, B, Liedvogel, H J, Lakomek, W, Northemann
Publikováno v: BioTechniques. 11(3)
Autoantibodies directed against the 68-kDa (U1) ribonucleoprotein antigen are mainly found in sera of patients with mixed connective tissue disease. The corresponding cDNA was fragmented into four regions coding for the major antigenic epitopes A', B
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::214a3d9247f451b7beff2a68da5331eb
https://pubmed.ncbi.nlm.nih.gov/1718330
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje