Sudan-β-d-glucuronides and their use for the histochemical localization of β-glucuronidase activity in transgenic plants

Autor: M. Van Montagu, G. Carlens, Nancy Terryn, M. Claeyssens, Jan Goeman, E. Van der Eycken, W. Nerinckx, Gilbert Engler, M. Brito-Arias, J. Van der Eycken

Publikováno v: Plant cell reports. 19(10)

Synthesis of five different Sudan-β-D-glucuronides (I, II, III, IV, and RedB) was performed by condensation of a set of red Sudan diazo dyes with methyl (1-deoxy-2,3,4-tri-O-acetyl-1-trichloroacetimidoyl-α-D-glucopyran)uronate. After the acid and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77778fd5e20c66a8fd18e9683f58d2d
https://pubmed.ncbi.nlm.nih.gov/30754840

Design and synthesis of pyridazin-4-one derivatives as necroptosis inhibitors.

Autor: An Y; Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China., Peng X; Cancer Research Center, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China., Wang T; Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China., Liu K; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China.; Cancer Research Center, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China.; School of Life Sciences and Technology, ShanghaiTech University, Shanghai, China., Feng D; Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China.; State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, People's Republic of China., Fang C; Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China., Zhou X; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China.; Cancer Research Center, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China., Geng M; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China.; Cancer Research Center, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China.; School of Life Sciences and Technology, ShanghaiTech University, Shanghai, China.; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, China., Duan W; Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China.; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China.; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, China., Ai J; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China.; Cancer Research Center, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China., Zhang H; Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Nov 21, pp. e2400594. Date of Electronic Publication: 2024 Nov 21.

An improved synthesis of 1α-hydroxy Vitamin D3

Autor: W. Nerinckx, Halkes Sebastianus J, Wilhelmus R M Overbeek, P. De Clercq, C. Couwenhoven

Publikováno v: Tetrahedron. 47:9419-9430

The efficient and stereoselective introduction of the 1α-OH function in vitamin D3 is described starting from the known previtamin D3 adduct 6. The sequence involves the stereoselective allylic bromination to 9, followed by substitution with mercuri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55e533ac1376fc1ee5ef094be34a6f6a
https://doi.org/10.1016/s0040-4020(01)80888-7

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Substrate specificity in glycoside hydrolase family 10. Tyrosine 87 and leucine 314 play a pivotal role in discriminating between glucose and xylose binding in the proximal active site of Pseudomonas cellulosa xylanase 10A

Autor: S R, Andrews, S J, Charnock, J H, Lakey, G J, Davies, M, Claeyssens, W, Nerinckx, M, Underwood, M L, Sinnott, R A, Warren, H J, Gilbert

Publikováno v: The Journal of biological chemistry. 275(30)

The Pseudomonas family 10 xylanase, Xyl10A, hydrolyzes beta1, 4-linked xylans but exhibits very low activity against aryl-beta-cellobiosides. The family 10 enzyme, Cex, from Cellulomonas fimi, hydrolyzes aryl-beta-cellobiosides more efficiently than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4d3fb9c0b95459048e8c626a6055870
https://pubmed.ncbi.nlm.nih.gov/10767281