Zobrazeno 1 - 10
of 123
pro vyhledávání: '"W, Neef"'
Autor:
Rocio Gomez-Pastor, Eileen T. Burchfiel, Daniel W. Neef, Alex M. Jaeger, Elisa Cabiscol, Spencer U. McKinstry, Argenia Doss, Alejandro Aballay, Donald C. Lo, Sergey S. Akimov, Christopher A. Ross, Cagla Eroglu, Dennis J. Thiele
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Huntington’s disease (HD) is caused by misfolding of mutant Htt protein. The authors find that in HD models, the decreased expression of heat shock transcription factor 1 that usually protects against protein misfolding, is in part caused by elevat
Externí odkaz:
https://doaj.org/article/10e213fe581949ff9cd3a516b23f2861
Autor:
Daniel W. Neef, Alex M. Jaeger, Rocio Gomez-Pastor, Felix Willmund, Judith Frydman, Dennis J. Thiele
Publikováno v:
Cell Reports, Vol 9, Iss 3, Pp 955-966 (2014)
Heat shock transcription factor 1 (HSF1) is an evolutionarily conserved transcription factor that protects cells from protein-misfolding-induced stress and apoptosis. The mechanisms by which cytosolic protein misfolding leads to HSF1 activation have
Externí odkaz:
https://doaj.org/article/52d1219d3ab343a2a033a9ffa76fb02e
Autor:
Marina Yamamoto Raynbird, Daniel W. Neef, Shaista S. Khokhar, Gareth J. S. Evans, Thomas Wirth
Publikováno v:
Chemistry – A European Journal. 27:3008-3012
Ajoene is a compound found in garlic extracts exhibiting a large range of biological activity. Novel ajoene analogues have been prepared in the search of compounds with superior bioactivity. Modifications include the alteration of the sulfoxide, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfed22a5670ed0881bcd53e3ec270d12
https://doi.org/10.1002/chem.202005023
https://doi.org/10.1002/chem.202005023
Autor:
Filipa V.M. Silva, Gareth J. S. Evans, Thomas Wirth, Shaista S. Khokhar, Daniel W. Neef, Marina Yamamoto Raynbird, Harry R. Smallman
Publikováno v:
Chemistry – A European Journal. 26:8363-8367
A short total synthesis of ajoene, (E,Z )‐4,5,9‐trithiadodeca‐1,6,11‐triene 9‐oxide, has been achieved over six steps. In addition, a continuous flow synthesis under mild reaction conditions to (E,Z )‐4,5,9‐trithiadodeca‐1,7,11‐trie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56315e5f4a79f1791f4507901893c1b1
https://doi.org/10.1002/chem.202001598
https://doi.org/10.1002/chem.202001598
Publikováno v:
Probiotics and Antimicrobial Proteins. 12:1097-1114
In this study, we describe enhanced in vitro probiotic activities of preformed biofilms versus planktonic cultures of Lactobacillus fermentum LfQi6 (LfQi6), a lactic acid bacterium (LAB) isolated from the human microbiome. These evaluations are used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59fd20ee17f6b362f90a9cf943e4908b
https://doi.org/10.1007/s12602-019-09624-8
https://doi.org/10.1007/s12602-019-09624-8
Autor:
Daniel W. Neef, Marina Yamamoto Raynbird, Shaista S. Khokhar, Thomas Wirth, Gareth J. S. Evans
Publikováno v:
Chemistry – A European Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cff53c0991edfe21eb329c0e9a25d530
https://doi.org/10.1002/chem.202180963
https://doi.org/10.1002/chem.202180963
Autor:
Liliana Batista-Nascimento, Daniel W Neef, Phillip C C Liu, Claudina Rodrigues-Pousada, Dennis J Thiele
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15976 (2011)
Heat shock transcription factor 1 (HSF1) plays an important role in the cellular response to proteotoxic stresses. Under normal growth conditions HSF1 is repressed as an inactive monomer in part through post-translation modifications that include pro
Externí odkaz:
https://doaj.org/article/81d8c7c9fdcc41b499ae5af3f0cd60fa
Publikováno v:
PLoS Biology, Vol 8, Iss 1, p e1000291 (2010)
Neurodegenerative diseases such as Huntington disease are devastating disorders with no therapeutic approaches to ameliorate the underlying protein misfolding defect inherent to poly-glutamine (polyQ) proteins. Given the mounting evidence that elevat
Externí odkaz:
https://doaj.org/article/26177a9717d34cb3b2d9fce98b6aaab0
Autor:
Marina Yamamoto Raynbird, Gareth J. S. Evans, Daniel W. Neef, Shaista S. Khokhar, Harry R. Smallman, Filipa V.M. Silva, Thomas Wirth
Publikováno v:
Chemistry – A European Journal. 26:8316-8316
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::836960f0205e1073c143a16d97335c74
https://doi.org/10.1002/chem.202002760
https://doi.org/10.1002/chem.202002760
Autor:
Dennis J. Thiele, Daniel W. Neef, Alex M. Jaeger, Rocío Gómez-Pastor, Felix Willmund, Judith Frydman
Publikováno v:
Cell Reports, Vol 9, Iss 3, Pp 955-966 (2014)
SummaryHeat shock transcription factor 1 (HSF1) is an evolutionarily conserved transcription factor that protects cells from protein-misfolding-induced stress and apoptosis. The mechanisms by which cytosolic protein misfolding leads to HSF1 activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ee9436d503643c9efb0ad9eda26c7d
https://doi.org/10.1016/j.celrep.2014.09.056
https://doi.org/10.1016/j.celrep.2014.09.056