Zobrazeno 1 - 10
of 65
pro vyhledávání: '"W, Morozowich"'
Autor:
W. Morozowich, H. A. Karnes
Publikováno v:
Prodrugs ISBN: 9780387497822
The prodrug clindamycin 2-phosphate is rapidly converted in vivo to the parent drug, clindamycin, by phosphatase ester hydrolysis. Clindamycin is an antibacterial agent used orally in treating gram-positive infections, anaerobic infections, and methi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b3cd93671f9a7c724c60f3eb24abb0
https://doi.org/10.1007/978-0-387-49785-3_38
https://doi.org/10.1007/978-0-387-49785-3_38
Autor:
W. Morozowich, M. J. Hageman
Publikováno v:
Prodrugs ISBN: 9780387497822
Irinotecan (CPT-11) is a potent anticancer agent approved for use in the treatment of advanced colorectal cancer, as either a first-line therapy in combination with 5-fluorouracil or in the treatment of 5-flurouracil refractory cases (Sawada et al.,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::895a6e13e6f4d37e6e7420eaa30954b0
https://doi.org/10.1007/978-0-387-49785-3_44
https://doi.org/10.1007/978-0-387-49785-3_44
Autor:
W J, Adams, P A, Aristoff, R K, Jensen, W, Morozowich, D L, Romero, W C, Schinzer, W G, Tarpley, R C, Thomas
Publikováno v:
Pharmaceutical biotechnology. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5994024579b9ccdb4d8e19693b0475e1
https://pubmed.ncbi.nlm.nih.gov/9760685
https://pubmed.ncbi.nlm.nih.gov/9760685
Publikováno v:
AJNR Am J Neuroradiol
A simple model for the simultaneous passive membrane transport and bioconversion of a drug, which may be a weak electrolyte or a neutral molecule, is mathematically described. It includes an aqueous diffusion layer and an operational aqueous pore pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be999641d0caa51498717230ff6a3d4d
https://doi.org/10.1016/0022-5193(76)90112-0
https://doi.org/10.1016/0022-5193(76)90112-0
Autor:
W. Morozowich, John G. Wagner, Jack I. Northam, A. Purmalis, P.M. Jones, T. Chulski, William E. Hamlin
Publikováno v:
Journal of Pharmaceutical Sciences. 51:993-996
Salt formation of benzphetamine and etryptamine as a potential means of obtaining sustained release and/or prolonged action was studied by measuring the median lethal time (LT50) in mice and its relationship to in vitro dissolution rates and solubili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc6f84973ad8664f2fe8c8137e575f33
https://doi.org/10.1002/jps.2600511020
https://doi.org/10.1002/jps.2600511020
Publikováno v:
Journal of Pharmaceutical Sciences. 61:1861-1895
Prostaglandins are analogs of the parent 20 carbon prostanoic acid. They are divided into 4 series: PGE; PGF; PGA; PGB, according to the presence of functionalities in the cyclopentane structure. Biosynthesis of prostaglandins were first independentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515fa4b9f1b28aaac489b3f8a6f935e5
https://doi.org/10.1002/jps.2600611202
https://doi.org/10.1002/jps.2600611202
Publikováno v:
Journal of pharmaceutical sciences. 73(11)
In situ absorption studies with dinoprost in the rat jejunum were carried out using a modified Doluisio technique. The absorption rate was first order. There was a sigmoidal decrease in the rate with increasing buffer pH (from 3.5 to 9.5), which stro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3eb053591bd36a7e24aad232fc615b9
https://pubmed.ncbi.nlm.nih.gov/6596427
https://pubmed.ncbi.nlm.nih.gov/6596427
Publikováno v:
Journal of pharmaceutical sciences. 73(11)
In situ absorption studies with dinoprostone in the rat jejunum were carried out to provide a quantitative mechanistic insight of the absorption process. The variables included buffer pH (3.5–9.5), buffer capacity, hydrodynamics in the lumen, and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5745bbd857e905045f91c0bedc5df5
https://pubmed.ncbi.nlm.nih.gov/6596428
https://pubmed.ncbi.nlm.nih.gov/6596428
Publikováno v:
Chemischer Informationsdienst. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad9c7979c74e49783a77f4c0cf611f64
https://doi.org/10.1002/chin.197316199
https://doi.org/10.1002/chin.197316199
Autor:
W, MOROZOWICH, F W, BOPE
Publikováno v:
Journal of the American Pharmaceutical Association. American Pharmaceutical Association. 47(3, Part 1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4cd1842f2acdcfbf911b299b8377427e
https://pubmed.ncbi.nlm.nih.gov/13525213
https://pubmed.ncbi.nlm.nih.gov/13525213