Zobrazeno 1 - 10
of 481
pro vyhledávání: '"W, Michels"'
Autor:
Angela M. Mitchell, Erin E. Baschal, Kristen A. McDaniel, Kimber M. Simmons, Laura Pyle, Kathleen Waugh, Andrea K. Steck, Liping Yu, Peter A. Gottlieb, Marian J. Rewers, Maki Nakayama, Aaron W. Michels
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
T cell receptor (TCR) sequences are exceptionally diverse and can now be comprehensively measured with next-generation sequencing technologies. However, a thorough investigation of longitudinal TCR repertoires throughout childhood in health and durin
Externí odkaz:
https://doaj.org/article/fdd60e79e23f4d1292274bdb7907007f
Autor:
Maki Nakayama, Aaron W. Michels
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T cell receptors (TCRs) are unique markers that define antigen specificity for a given T cell. With the evolution of sequencing and computational analysis technologies, TCRs are now prime candidates for the development of next-generation non-cell bas
Externí odkaz:
https://doaj.org/article/60aa1c3c389c4b8aad4bb498f379bb27
Autor:
Ren-You Pan, Mu-Tzu Chu, Chuang-Wei Wang, Yun-Shien Lee, Francois Lemonnier, Aaron W. Michels, Ryan Schutte, David A. Ostrov, Chun-Bing Chen, Elizabeth Jane Phillips, Simon Alexander Mallal, Maja Mockenhaupt, Teresa Bellón, Wichittra Tassaneeyakul, Katie D. White, Jean-Claude Roujeau, Wen-Hung Chung, Shuen-Iu Hung
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Severe cutaneous adverse reactions (SCAR) is a T cell-mediated, potentially lethal drug hypersensitivity (DH). Here, the authors identify a carbamazepine-specific TCR common among patients with carbamazepine-induced SCAR that confers SCAR-like pathol
Externí odkaz:
https://doaj.org/article/38d2c02fdc28404082a384a33f386ffd
Autor:
Laurie G. Landry, Amanda M. Anderson, Holger A. Russ, Liping Yu, Sally C. Kent, Mark A. Atkinson, Clayton E. Mathews, Aaron W. Michels, Maki Nakayama
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Proinsulin is an abundant protein that is selectively expressed by pancreatic beta cells and has been a focus for development of antigen-specific immunotherapies for type 1 diabetes (T1D). In this study, we sought to comprehensively evaluate reactivi
Externí odkaz:
https://doaj.org/article/a91cd3ee2151464383c8205ba8eb1435
Autor:
Sarah E. Mann, Zhicheng Zhou, Laurie G. Landry, Amanda M. Anderson, Aimon K. Alkanani, Jeremy Fischer, Mark Peakman, Roberto Mallone, Kristen Campbell, Aaron W. Michels, Maki Nakayama
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Recent advancements in single cell sequencing technologies allow for identification of numerous immune-receptors expressed by T cells such as tumor-specific and autoimmune T cells. Determining antigen specificity of those cells holds immense therapeu
Externí odkaz:
https://doaj.org/article/1ad9f4fd08954056b50904453b43f4fa
Autor:
Maki Nakayama, Aaron W. Michels
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Type 1 diabetes, the immune mediated form of diabetes, represents a prototypical organ specific autoimmune disease in that insulin producing pancreatic islets are specifically targeted by T cells. The disease is now predictable in humans with the mea
Externí odkaz:
https://doaj.org/article/888735439b2b4e04b922ece601a29695
Publikováno v:
Diabetes Technology & Therapeutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f8d1e9da1c66134956ba05cc08eae2a
https://doi.org/10.1089/dia.2023.0016
https://doi.org/10.1089/dia.2023.0016
Publikováno v:
Diabetes. 71
Background: Insulinoma antigen-2 (IA2) is a major self-antigen in T1D with post translational modification (PTM) of the extracellular domain (IA2ec) by deamidation eliciting T cell responses in T1D patients. Yet the autoantibodies (Abs) to these IA2e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd80a51304980bbc3b3b6e5ae521bcfa
https://doi.org/10.2337/db22-186-or
https://doi.org/10.2337/db22-186-or
Autor:
KIMBER M. SIMMONS, TIMOTHY B. VIGERS, LAURA PYLE, ERIN M. YOUNGKIN, ERIN E. BASCHAL, KRISTEN MCDANIEL, LIPING YU, AARON W. MICHELS
Publikováno v:
Diabetes. 71
The incidence of type 1 diabetes continues to increase, most notably in American Hispanic (HIS) youth. Type 1 diabetes autoimmunity has not been fully characterized in HIS youth. Determining the prevalence of islet autoantibody positivity in HIS yout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f83f1d6ab182fbe3e3ce43ae05070b39
https://doi.org/10.2337/db22-1187-p
https://doi.org/10.2337/db22-1187-p
Autor:
ANGELA M. MITCHELL, ERIN E. BASCHAL, KRISTEN MCDANIEL, LAURA PYLE, KATHLEEN WAUGH, ANDREA STECK, LIPING YU, PETER GOTTLIEB, MARIAN REWERS, MAKI NAKAYAMA, AARON W. MICHELS
Publikováno v:
Diabetes. 71
In type 1 diabetes (T1D) , T cells target and destroy pancreatic beta cells. T cells express T cell receptors (TCRs) which recognize peptide antigens, and each TCR is unique to a given T cell. To understand the TCR repertoire during T1D development,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cc37d7676dd554cd6ddb34979404c79
https://doi.org/10.2337/db22-185-or
https://doi.org/10.2337/db22-185-or