Zobrazeno 1 - 10
of 254
pro vyhledávání: '"W, MODELL"'
Autor:
Rachael E. Workman, Marie J. Stoltzfus, Nicholas C. Keith, Chad W. Euler, Joseph Bondy-Denomy, Joshua W. Modell
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113849- (2024)
Summary: CRISPR-Cas immune systems provide bacteria with adaptive immunity against bacteriophages, but they are often transcriptionally repressed to mitigate auto-immunity. In some cases, CRISPR-Cas expression increases in response to a phage infecti
Externí odkaz:
https://doaj.org/article/8f1d1d1e943a4010b6fec27b0be2675a
Publikováno v:
PLoS Biology, Vol 20, Iss 11 (2022)
Gene transfer agents (GTAs) are prophage-like entities found in many bacterial genomes that cannot propagate themselves and instead package approximately 5 to 15 kbp fragments of the host genome that can then be transferred to related recipient cells
Externí odkaz:
https://doaj.org/article/7f46fba97d3e4972854de4bec6c4e3a9
Autor:
Gregory W. Goldberg, Elizabeth A. McMillan, Andrew Varble, Joshua W. Modell, Poulami Samai, Wenyan Jiang, Luciano A. Marraffini
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
CRISPR-Cas systems, such as type III-A CRISPR-Cas, provide an immune mechanism for prokaryotic hosts to resist parasites, including phages. Here, the authors show that maintenance of conditionally tolerant type III-A systems can affect the fitness of
Externí odkaz:
https://doaj.org/article/26a41b550ed54bc689c612ad1492998b
Publikováno v:
Cell Host Microbe
CRISPR-Cas systems provide immunity to bacteria by programing Cas nucleases with RNA guides that recognize and cleave infecting viral genomes. Bacteria and their viruses each encode recombination systems that could repair the cleaved viral DNA. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13a2105281cffde9009e042d25c1ae1
https://europepmc.org/articles/PMC8516739/
https://europepmc.org/articles/PMC8516739/
Publikováno v:
PLoS Biology, Vol 12, Iss 10, p e1001977 (2014)
Cells must coordinate DNA replication with cell division, especially during episodes of DNA damage. The paradigm for cell division control following DNA damage in bacteria involves the SOS response where cleavage of the transcriptional repressor LexA
Externí odkaz:
https://doaj.org/article/9b399878511e446dbf56b58fa65f4a77
Cleavage of viral DNA by restriction endonucleases stimulates the type II CRISPR-Cas immune response
Publikováno v:
Mol Cell
Prokaryotic organisms have developed multiple defense systems against phages; however, little is known about whether and how these interact with each other. Here, we studied the connection between two of the most prominent prokaryotic immune systems:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1b3c1df8bcd9c52f98f7856e71bfb1
https://pubmed.ncbi.nlm.nih.gov/35469710
https://pubmed.ncbi.nlm.nih.gov/35469710
Autor:
Binh T. K. Nguyen, Suzanne Sebald, Marie J. Stoltzfus, Rachael E. Workman, Joshua W. Modell, Leonardo W. Graeff, Erika Smith, Teja Pammi
SUMMARYCRISPR-Cas systems provide their prokaryotic hosts with acquired immunity against viruses and other foreign genetic elements, but how these systems are regulated to prevent auto-immunity is poorly understood. In type II CRISPR-Cas systems, a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6142d71e18b5ede32f9d213d6043719c
https://doi.org/10.1101/2020.05.21.102756
https://doi.org/10.1101/2020.05.21.102756
Autor:
Poulami Samai, Andrew Varble, Gregory W. Goldberg, Joshua W. Modell, Luciano A. Marraffini, Wenyan Jiang, Elizabeth A. McMillan
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
CRISPR–Cas systems offer an immune mechanism through which prokaryotic hosts can acquire heritable resistance to genetic parasites, including temperate phages. Co-transcriptional DNA and RNA targeting by type III-A CRISPR–Cas systems restricts te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77faa869d4f0d295c1b84db9e4f69047
https://doi.org/10.1038/s41467-017-02557-2
https://doi.org/10.1038/s41467-017-02557-2
Autor:
Catherine L. Weiner, Poulami Samai, Luciano A. Marraffini, Gregory W. Goldberg, Robert Heler, Joshua W. Modell, David Bikard
Publikováno v:
Nature
Nature, 2015, 519 (7542), pp.199-202. ⟨10.1038/nature14245⟩
Nature, Nature Publishing Group, 2015, 519 (7542), pp.199-202. ⟨10.1038/nature14245⟩
Nature, 2015, 519 (7542), pp.199-202. ⟨10.1038/nature14245⟩
Nature, Nature Publishing Group, 2015, 519 (7542), pp.199-202. ⟨10.1038/nature14245⟩
International audience; Clustered regularly interspaced short palindromic repeat (CRISPR) loci and their associated (Cas) proteins provide adaptive immunity against viral infection in prokaryotes. Upon infection, short phage sequences known as spacer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846518b24d04f6f8d203528c99bdcea4
http://europepmc.org/articles/PMC4385744
http://europepmc.org/articles/PMC4385744
Publikováno v:
Nature. 544(7648)
Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems provide protection against viral and plasmid infection by capturing short DNA sequences from these invaders and integrating them into the CRISPR locus of the prokaryotic h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27453ac4eb27a2736244dab332662622
https://pubmed.ncbi.nlm.nih.gov/28392559
https://pubmed.ncbi.nlm.nih.gov/28392559