Zobrazeno 1 - 10
of 3 029
pro vyhledávání: '"W, Lutz"'
Autor:
E. Keats Shwab, Daniel C. Gingerich, Zhaohui Man, Julia Gamache, Melanie E. Garrett, Gregory E. Crawford, Allison E. Ashley-Koch, Geidy E. Serrano, Thomas G. Beach, Michael W. Lutz, Ornit Chiba-Falek
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-30 (2024)
Abstract The genetic architecture of Parkinson’s disease (PD) is complex and multiple brain cell subtypes are involved in the neuropathological progression of the disease. Here we aimed to advance our understanding of PD genetic complexity at a cel
Externí odkaz:
https://doaj.org/article/c4ba46884caf45f480e2da17f07a08a6
Autor:
Yuan Yuan, Huizhong Li, Kashyap Sreeram, Tuyana Malankhanova, Ravindra Boddu, Samuel Strader, Allison Chang, Nicole Bryant, Talene A. Yacoubian, David G. Standaert, Madalynn Erb, Darren J. Moore, Laurie H. Sanders, Michael W. Lutz, Dmitry Velmeshev, Andrew B. West
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-23 (2024)
Abstract Background LRRK2-targeting therapeutics that inhibit LRRK2 kinase activity have advanced to clinical trials in idiopathic Parkinson’s disease (iPD). LRRK2 phosphorylates Rab10 on endolysosomes in phagocytic cells to promote some types of i
Externí odkaz:
https://doaj.org/article/cbe5ed539df9444082143ccaca2754bf
Autor:
Xiaoxiao Zhou, Haotian Zou, Michael W. Lutz, Konstantin Arbeev, Igor Akushevich, Anatoli Yashin, Kathleen A. Welsh‐Bohmer, Sheng Luo
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION Alzheimer's disease (AD) is a neurodegenerative disorder characterized by declines in cognitive and functional severities. This research utilized the Clinical Dementia Rating (CDR) to assess the influence of tilavonemab on these
Externí odkaz:
https://doaj.org/article/f8a70948cfeb4f45b43b936ba7a13d27
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 1, Pp n/a-n/a (2024)
Abstract INTRODUCTION Phase 3 trials using the anti‐amyloid antibodies aducanumab, lecanemab, donanemab, and high‐dose gantenerumab in prodromal and mild Alzheimer's disease dementia were heterogeneous in respect to statistical significance of ef
Externí odkaz:
https://doaj.org/article/4dea5d4c6238409c819547aaae9fcee3
Autor:
Yi Zeng, Huashuai Chen, Xiaomin Liu, Zijun Song, Yao Yao, Xiaoyan Lei, Xiaozhen Lv, Lingguo Cheng, Zhihua Chen, Chen Bai, Zhaoxue Yin, Yuebin Lv, Jiehua Lu, Jianxin Li, Kenneth C. Land, Anatoliy Yashin, Angela M. O'Rand, Liang Sun, Ze Yang, Wei Tao, Jun Gu, William Gottschalk, Qihua Tan, Kaare Christensen, Therese Hesketh, Xiao-Li Tian, Huanming Yang, Viviana Egidi, Graziella Caselli, Jean-Marie Robine, Huali Wang, Xiaoming Shi, James W. Vaupel, Michael W. Lutz, Chao Nie, Junxia Min
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23691- (2024)
It is long observed that females tend to live longer than males in nearly every country. However, the underlying mechanism remains elusive. In this study, we discovered that genetic associations with longevity are on average stronger in females than
Externí odkaz:
https://doaj.org/article/4e57bb6e16fe4cc6aea7dbad954c40b9
Publikováno v:
Frontiers in Systems Biology, Vol 3 (2023)
The principles governing genotype-phenotype relationships are still emerging (Jovanovic, Science, 2015, 347 (6,226), 1,259,038; Buccitelli et al., Nature Reviews Genetics, 2020, 21 (10), 630–44; Öztürk et al., Nature Communications, 2022, 131), 6
Externí odkaz:
https://doaj.org/article/63718dbc7b784b55af19e1a001c8434a
Autor:
Jennifer H. Kang, Michael L. James, Allison Gibson, Ovais Inamullah, Gary Clay Sherrill, Michael W. Lutz, Christa B. Swisher
Publikováno v:
Journal of Neuroanaesthesiology and Critical Care, Vol 08, Iss 03, Pp 203-207 (2021)
Aim Patients with mechanical heart valves and coexisting atrial fibrillation (AFib-MHV) who suffer an intraparenchymal hemorrhage (IPH, defined as bleeding solely within the brain parenchyma and/or ventricle) are at a high risk of thromboembolism wit
Externí odkaz:
https://doaj.org/article/316dd5bdaf3c47da93131d74d0a8fcbf
Autor:
Aida Kamalian, Sara G. Ho, Megha Patel, Alexandria Lewis, Arnold Bakker, Marilyn Albert, Richard J. O’Brien, Abhay Moghekar, Michael W. Lutz
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1094 (2023)
(1) Background: Despite the existence of well-established, CSF-based biomarkers such as amyloid-β and phosphorylated-tau, the pathways involved in the pathophysiology of Alzheimer’s disease (AD) remain an active area of research. (2) Methods: We m
Externí odkaz:
https://doaj.org/article/ecf717b7883040bfae72c947d41fce94
Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms
Autor:
Karissa L. Gable, Stojan Peric, Michael W. Lutz, Ivo Bozovic, Milutin Petrovic, Aleksandar Stojanov, Ivana Basta, Jeffrey A. Allen
Publikováno v:
Brain and Behavior, Vol 12, Iss 8, Pp n/a-n/a (2022)
Abstract Background and aims Fatigue is a common but poorly understood complaint in patients with immune‐mediated polyneuropathies. We sought to evaluate changes in fatigue over 1 year in a cohort of chronic inflammatory demyelinating polyneuropath
Externí odkaz:
https://doaj.org/article/7a376e75d57c4999ab1ac12bee9a257b