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Dynamics and binding mode of Hoechst 33258 to d(GTGGAATTCCAC)2 in the 1:1 solution complex as determined by two-dimensional 1H NMR

Autor: A, Fede, A, Labhardt, W, Bannwarth, W, Leupin

Publikováno v: Biochemistry. 30(48)

We have investigated the interaction of the bisbenzimidazole derivative Hoechst 33258 with the self-complementary dodecadeoxynucleotide duplex d(GTGGAATTCCAC)2 using one-dimensional (1D) and two-dimensional (2D) proton nuclear magnetic resonance (1H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c0f8c638182b97319224bc40c4c36c76
https://pubmed.ncbi.nlm.nih.gov/1720660

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Two-dimensional 1H NMR studies of synthetic immobile Holliday junctions

Autor: S M, Chen, F, Heffron, W, Leupin, W J, Chazin

Publikováno v: Biochemistry. 30(3)

Two 32 base pair, four-arm immobile Holliday junctions have been prepared and studied by two-dimensional 1H nuclear magnetic resonance (NMR) spectroscopy. Two-quantum spectroscopy provides scalar (through bond) correlations for the 1'H, 2'H, and 2''H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89b88eb95b01877515c91984100430db
https://pubmed.ncbi.nlm.nih.gov/1988063

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Experimental Proofs of A Drug’s DNA Specificity

Autor: W. Leupin

Publikováno v: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ISBN: 9789401056571

In the first part of this account we briefly review biophysical and biochemical methods used for the evaluation of the binding affinity and specificity of small ligands interacting with double-stranded DNA. Based on their simplicity, low consumption

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e76940d4d058cdeea00e15bdc03aaec
https://doi.org/10.1007/978-94-011-3728-7_37

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Infrared and Raman studies show that poly(dA).cntdot.poly(dT) and d(AAAAATTTTT)2 exhibit a heteronomous conformation in films at 75% relative humidity and a B-type conformation at high humidities and in solution

Autor: E. Taillandier, Yang Wang, W. A. Denny, Jean Liquier, W. Leupin, G. A. Thomas, W. L. Peticolas, J. P. Ridoux

Publikováno v: Biochemistry. 26:3361-3368

The decadeoxynucleotide d(AAAAATTTTT)2 in duplex form and the double-helical polynucleotide poly(dA).poly(dT) have been studied by Raman and infrared (IR) spectroscopy under a variety of environmental conditions. The IR spectra have been taken of cas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7487bfd6c26ea870f4418a0099e11da
https://doi.org/10.1021/bi00386a017

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Picosecond fluorescence from the second excited singlet state of cycl[3.3.3]azine, a bridge 12.pi.-perimeter annulene. Spectra and kinetics for S2 .fwdarw. S0 and S2 .fwdarw. S1 transitions

Autor: W. Leupin, S. J. Berens, Jakob Wirz, Douglas Magde

Publikováno v: The Journal of Physical Chemistry. 88:1376-1379

La duree de vie du second etat singulet excite du compose cite a ete determinee en mesurant le declin de la fluorescence bleu S 2 →S 0 . Les emissions dans le proche IR sont attribuees a la fluorescence S 2 →S 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f2bd6e3067cbd31284f8edbaecac1b8
https://doi.org/10.1021/j150651a028

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Sequence-specific assignment of the backbone1H- and31P-nmr lines in a short DNA duplex with homo- and heteronuclear correlated spectroscopy

Autor: M. H. Frey, W. Leupin, O. W. Sørensen, W. A. Denny, R. R. Ernst, K. Wüthrich

Publikováno v: Biopolymers. 24:2371-2380

We report the assignment of the backbone 1H- and 31P-nmr lines in the synthetic hexadeoxyribonucleotide pentaphosphate duplex d(GCATGC)2, using double quantum filtered 1H-1H correlation spectroscopy, 1H observed 1H-31P heteronuclear correlation spect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c40c0172ccff1641ef977bc3b75edd0
https://doi.org/10.1002/bip.360241214

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Conformational studies of d-(AAAAATTTTT)2 using constraints from nuclear overhauser effects and from quantitative analysis of the cross-peak fine structures in two-dimensional 1H nuclear magnetic resonance spectra

Autor: B, Celda, H, Widmer, W, Leupin, W J, Chazin, W A, Denny, K, Wüthrich

Publikováno v: Biochemistry. 28(4)

The conformation at the dA-dT junction in d-(AAAAATTTTT)2 was investigated by using a variety of phase-sensitive two-dimensional nuclear magnetic resonance experiments at 500 MHz for detailed studies of the deoxyribose ring puckers. Conformational co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be714b64e1623b52e168f054b743decb
https://pubmed.ncbi.nlm.nih.gov/2719909

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