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Publikováno v:
Microchimica Acta. 102:283-303
Laser microprobe mass spectrometry (LMMS) offers a great potential for inorganic analysis and speciation as well as for organic structural characterization. This remarkable flexibility makes the results critically dependent on the experimental condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13d14d1fd46e4bf72f1a3648e864e279
https://doi.org/10.1007/bf01244770
https://doi.org/10.1007/bf01244770
Autor:
M.-C. Coene, G. Van Nyen, L. Le Jeune, C. Van Hove, J. Goossens, W. Lauwers, J. Van Wauwe, W. Cools
Publikováno v:
Biochemical pharmacology. 47(4)
The metabolism of 4-keto-all- trans -retinoic-acid (4-keto-RA), a biologically active oxygenated metabolite of all- trans -retinoic (RA), has been examined. In vitro , incubation of [ 14 C]4-keto-RA with hamster liver microsomes in the presence of NA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b12ca9334dc2e30ad85f9fff3003c8
https://pubmed.ncbi.nlm.nih.gov/8129749
https://pubmed.ncbi.nlm.nih.gov/8129749
Autor:
W, Meuldermans, J, Hendrickx, G, Mannens, K, Lavrijsen, C, Janssen, J, Bracke, L, Le Jeune, W, Lauwers, J, Heykants
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 22(1)
The metabolism and excretion of risperidone (RIS; 3-[2-[4-(6-fluoro-1,2-benzisoxazole-3-yl)-1-piperidinyl]ethyl]-6,7,8,9- tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one), a novel antipsychotic drug, were studied after single po administration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::630526e2c1c694436a452b69f0c977f7
https://pubmed.ncbi.nlm.nih.gov/7512019
https://pubmed.ncbi.nlm.nih.gov/7512019
Autor:
R Hurkmans, M. Bockx, W. Lauwers, D. Van Dyck, K. Lavrijsen, L. Le Jeune, J. Van Houdt, J. Heykants, Willem Meuldermans, J. Hendrickx
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 22(7)
1. The biotransformation of 3H-flunarizine ((E)-1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride, FLUN) was studied in subcellular liver fractions (microsomes and 12,000 g fraction) and in suspensions or primary cell cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29d2a4cd24e8a2379f7a6b05563c3e5
https://pubmed.ncbi.nlm.nih.gov/1455902
https://pubmed.ncbi.nlm.nih.gov/1455902
Publikováno v:
Eicosanoids. 5(3-4)
We have previously demonstrated that rat epidermal microsomes NADPH-dependently convert 15(S)-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HPETE) into 15-hydroxy-5,8,11-eicosatrienoic acid (15-HETrE). The present study examines the mechanism of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89fc3561c3eb587e56776695d491878b
https://pubmed.ncbi.nlm.nih.gov/1292524
https://pubmed.ncbi.nlm.nih.gov/1292524
Autor:
J, Van Wauwe, M C, Coene, G, Van Nyen, W, Cools, J, Goossens, L, Le Jeune, W, Lauwers, P A, Janssen
Publikováno v:
Eicosanoids. 4(3)
Rat epidermal microsomes were incubated with [1-14C]-arachidonic acid for 30 min at 37 degrees C in the absence and presence of NADPH. The arachidonate metabolites that eluted in the "monohydroxy acid fraction" on reverse-phase high performance liqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a017e908f95cdb40d56d2781fbb1e456
https://pubmed.ncbi.nlm.nih.gov/1772688
https://pubmed.ncbi.nlm.nih.gov/1772688
Autor:
Hugo Vanden Bossche, D. Bellens, J. Gorrens, M.-C. Coene, W. Lauwers, Ludo Le Jeune, Patrick Marichal, Paul A. J. Janssen, Henri Moereels
Publikováno v:
Mycoses in AIDS Patients ISBN: 9781461279129
During recent years considerable advances have been made in the identification of potential targets for antifungal agents. The most important antifungals for use in immunocompromised patients interfere with targets in the plasma membrane (polyenes),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59a6cafbb63decaea2a7b608f88720b8
https://doi.org/10.1007/978-1-4613-0655-9_22
https://doi.org/10.1007/978-1-4613-0655-9_22
Autor:
UdoA. Brinkman, Durk Fekkes, W. Lauwers, M.Joris Schouten, Lolke Pepplinkhuizen, Jacques Bruinvels
Publikováno v:
The Lancet. 339:506
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07b7d201ed41abc4ef91d275676a2b6
https://doi.org/10.1016/0140-6736(92)91128-u
https://doi.org/10.1016/0140-6736(92)91128-u
Publikováno v:
Drug Development Research. 8:37-51
The excretion and biotransformation of astemizole (AST) were studied after single administration in rats (0.16 or 10 mg/kg), guinea-pigs (0.16 mg/kg), dogs (1 or 10 mg/kg) and humans (30 mg), using three different radiolabels. Orally administered AST
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2bc8151a457eb5510793563050735db
https://doi.org/10.1002/ddr.430080106
https://doi.org/10.1002/ddr.430080106