Post-treatment monitoring by ASCL1/LHX8 methylation analysis in women with HIV treated for cervical intraepithelial neoplasia grade 2/3

Autor: Frederique J. Vink, Renske D.M. Steenbergen, Wieke W. Kremer, Birgit I. Lissenberg-Witte, Daniëlle A.M. Heideman, Maaike C.G. Bleeker, Marjolein van Zummeren, Erika Breytenbach, Cathy Visser, Azwidowi Lukhwareni, Chris J.L.M. Meijer, Greta Dreyer

Publikováno v: AIDS (London, England), 36(7), 953-961. Lippincott Williams and Wilkins
Vink, F J, Steenbergen, R D M, Kremer, W W, Lissenberg-Witte, B I, Heideman, D A M, Bleeker, M C G, van Zummeren, M, Breytenbach, E, Visser, C, Lukhwareni, A, Meijer, C J L M & Dreyer, G 2022, ' Post-treatment monitoring by ASCL1/LHX8 methylation analysis in women with HIV treated for cervical intraepithelial neoplasia grade 2/3 ', AIDS (London, England), vol. 36, no. 7, pp. 953-961 . https://doi.org/10.1097/QAD.0000000000003197

Objective:Women with HIV (WWH) have an increased risk to develop recurrent cervical intraepithelial neoplasia grade 2/3 (rCIN2/3) after treatment compared with HIV-negative women. Therefore, appropriate posttreatment monitoring of WWH is important. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0057fcc248c3853650a2db213c8cb807
https://research.vumc.nl/en/publications/368d8035-bcf9-4d12-b4f7-b5fda9373928

Clinical Regression of High-Grade Cervical Intraepithelial Neoplasia Is Associated With Absence of FAM19A4/miR124-2 DNA Methylation (CONCERVE Study)

Autor: Wieke W. Kremer, Stèfanie Dick, Daniëlle A.M. Heideman, Renske D.M. Steenbergen, Maaike C.G. Bleeker, Harold R. Verhoeve, W. Marchien van Baal, Nienke van Trommel, Gemma G. Kenter, Chris J.L.M. Meijer, Johannes Berkhof

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. American Society of Clinical Oncology
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 189:e2102433. American Society of Clinical Oncology
Kremer, W W, Dick, S, Heideman, D A M, Steenbergen, R D M, Bleeker, M C G, Verhoeve, H R, van Baal, W M, van Trommel, N, Kenter, G G, Meijer, C J L M & Berkhof, J 2022, ' Clinical Regression of High-Grade Cervical Intraepithelial Neoplasia Is Associated With Absence of FAM19A4/miR124-2 DNA Methylation (CONCERVE Study) ', Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol. 189, e2102433, pp. JCO2102433 . https://doi.org/10.1200/JCO.21.02433
Journal of Clinical Oncology, 189:e2102433. American Society of Clinical Oncology

PURPOSE Cervical screening can prevent cancer by detection and treatment of cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3). Screening also results in considerable overtreatment because many CIN2/3 lesions show spontaneous regression when le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effda8b855240bfdaeee96e37c9439c4
https://research.vumc.nl/en/publications/65040442-b625-4746-92f1-e159dc3c302a

The use of host cell DNA methylation analysis in the detection and management of women with advanced cervical intraepithelial neoplasia: A review

Autor: Christophorus Joannes Lambertus Maria Meijer, Renske D.M. Steenbergen, Wieke W. Kremer, Daniëlle A M Heideman, Gemma G. Kenter

Publikováno v: Kremer, W W, Steenbergen, R D M, Heideman, D A M, Kenter, G G & Meijer, C J L M 2021, ' The use of host cell DNA methylation analysis in the detection and management of women with advanced cervical intraepithelial neoplasia: A review ', Obstetrical and Gynecological Survey, vol. 76, no. 5, pp. 273-274 . https://doi.org/10.1097/ogx.0000000000000922
Bjog
Kremer, W W, Steenbergen, R, Heideman, D, Kenter, G G & Meijer, C 2021, ' The use of host cell DNA methylation analysis in the detection and management of women with advanced cervical intraepithelial neoplasia : a review ', BJOG: An International Journal of Obstetrics & Gynaecology, vol. 128, no. 3, pp. 504-514 . https://doi.org/10.1111/1471-0528.16395

This paper briefly reviews the role of hypermethylation of host cell genes in cervical carcinogenesis and discusses potential clinical applications of methylation analysis in the management of high‐risk HPV (hrHPV) ‐positive women. We argue that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99bd4b8f41b0dbc43c8cfb10bf51ccb
https://research.vumc.nl/en/publications/69cc2228-1f62-4f08-8e1e-b0f309389267

Three-tiered score for Ki-67 and p16ink4a improves accuracy and reproducibility of grading CIN lesions

Autor: Renske D.M. Steenbergen, Annemiek Leeman, Peter J.F. Snijders, Marjolein van Zummeren, Maaike C G Bleeker, Wieke W. Kremer, Chris J.L.M. Meijer, Johannes Berkhof, Daniëlle A.M. Heideman, Miekel M. van de Sandt, David G. Jenkins, Wim Quint

Publikováno v: Journal of Clinical Pathology

AimsTo investigate the accuracy and reproducibility of a scoring system for cervical intraepithelial neoplasia (CIN1–3) based on immunohistochemical (IHC) biomarkers Ki-67 and p16ink4a.Methods115 cervical tissue specimens were reviewed by three exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b1119ed680d75e8a705e6d0f7ba20e
http://europepmc.org/articles/PMC6225805

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