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Akademický článek

HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and resistance to neutralizing antibodies

Autor: Daniel W. Heindel, Dania M. Figueroa Acosta, Marisa Goff, Clauvis Kunkeng Yengo, Muzafar Jan, Xiaomei Liu, Xiao-Hong Wang, Mariya I. Petrova, Mo Zhang, Manish Sagar, Phillip Barnette, Shilpi Pandey, Ann J. Hessell, Kun-Wei Chan, Xiang-Peng Kong, Benjamin K. Chen, Lara K. Mahal, Barbara A. Bensing, Catarina E. Hioe

Publikováno v: iScience, Vol 27, Iss 8, Pp 110390- (2024)

Summary: Bacteria dysbiosis and its accompanying inflammation or compromised mucosal integrity is associated with an increased risk of HIV-1 transmission. However, HIV-1 may also bind bacteria or bacterial products to impact infectivity and transmiss

Externí odkaz: https://doaj.org/article/e5305c3f335e45a9a5819c9e033eed91

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Akademický článek

Intratumoral heterogeneity after targeted therapy in murine cancer models with differing degrees of malignancy

Autor: M. Gerwing, E. Hoffmann, C. Geyer, A. Helfen, B. Maus, R. Schinner, L. Wachsmuth, W. Heindel, M. Eisenblaetter, C. Faber, M. Wildgruber

Publikováno v: Translational Oncology, Vol 37, Iss , Pp 101773- (2023)

Introduction: Conventional morphologic and volumetric assessment of treatment response is not suitable for adequately assessing responses to targeted cancer therapy. The aim of this study was to evaluate changes in tumor composition after targeted th

Externí odkaz: https://doaj.org/article/48052c5966bf4f8ea45d896888f3858a

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Akademický článek

Vaccination with immune complexes modulates the elicitation of functional antibodies against HIV-1

Autor: Catarina E. Hioe, Xiaomei Liu, Andrew N. Banin, Daniel W. Heindel, Jéromine Klingler, Priyanka G. Rao, Christina C. Luo, Xunqing Jiang, Shilpi Pandey, Tracy Ordonez, Philip Barnette, Maxim Totrov, Jiang Zhu, Arthur Nádas, Susan Zolla-Pazner, Chitra Upadhyay, Xiaoying Shen, Xiang-Peng Kong, Ann J. Hessell

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionNeutralizing antibodies (Abs) are one of the immune components required to protect against viral infections. However, developing vaccines capable of eliciting neutralizing Abs effective against a broad array of HIV-1 isolates has been an

Externí odkaz: https://doaj.org/article/bd3b1a8708a244ec9f1494a4fcb1f13f

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Akademický článek

Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice.

Publikováno v: PLoS Pathogens, Vol 18, Iss 1, p e1010183 (2022)

Antibodies are principal immune components elicited by vaccines to induce protection from microbial pathogens. In the Thai RV144 HIV-1 vaccine trial, vaccine efficacy was 31% and the sole primary correlate of reduced risk was shown to be vigorous ant

Externí odkaz: https://doaj.org/article/fd5aefa035fe437aa866a6e470cde8fa

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Forensische Altersdiagnostik mittels Niederfeld-Magnetresonanztomographie

Autor: C. Ottow, S. Schmidt, R. Schulz, L. Sottmann, W. Heindel, T. Krähling, H. Pfeiffer, V. Vieth, A. Schmeling

Publikováno v: Rechtsmedizin. 33:96-104

Zusammenfassung Hintergrund Ein rechtlich zulässiges medizinisches Altersfeststellungsverfahren mit möglichst schonenden und zuverlässigen Methoden bei unbegleiteten und fraglich minderjährigen Ausländern ist erforderlich, um den tatsächlich Mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36d36c8d08c475035d7e6e109822a7e2
https://doi.org/10.1007/s00194-022-00588-8

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