Výsledky vyhledávání

Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling

Autor: Israel Matos, Maunish Barvalia, Manreet K. Chehal, A. Gordon Robertson, Iva Kulic, Jessica A.F.D. Silva, Abhinandan Ranganathan, Amy Short, Yu-Hsuan Huang, Erin Long, John J. Priatel, Salim Dhanji, Brad H. Nelson, Danielle L. Krebs, Kenneth W. Harder

Publikováno v: Cancer Research Communications. 3:404-419

While immunotherapies such as immune checkpoint blockade and adoptive T-cell therapy improve survival for a subset of human malignancies, many patients fail to respond. Phagocytes including dendritic cells (DC), monocytes, and macrophages (MF) orches

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c58b03e0d87c5b4e0ad543399513670
https://doi.org/10.1158/2767-9764.crc-22-0278

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Male microbiota-associated metabolite restores macrophage efferocytosis in female lupus-prone mice via activation of PPARγ/LXR signaling pathways

Autor: James W Harder, Jing Ma, Pascale Alard, Kevin J Sokoloski, Edith Mathiowitz, Stacia Furtado, Nejat K Egilmez, Michele M Kosiewicz

Publikováno v: Journal of Leukocyte Biology. 113:41-57

Systemic lupus erythematosus development is influenced by both sex and the gut microbiota. Metabolite production is a major mechanism by which the gut microbiota influences the immune system, and we have previously found differences in the fecal meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5102cfbc1696245e7a2e9ae7c564685
https://doi.org/10.1093/jleuko/qiac002

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Figure S1 from Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling

Autor: Kenneth W. Harder, Danielle L. Krebs, Brad H. Nelson, Salim Dhanji, John J. Priatel, Erin Long, Yu-Hsuan Huang, Amy Short, Abhinandan Ranganathan, Jessica A.F.D. Silva, Iva Kulic, A. Gordon Robertson, Manreet K. Chehal, Maunish Barvalia, Israel Matos

Supplementary Figure S1 shows the characterization of MT and MTG-CSF-/- cell lines and tumors, including surface protein expression, tumor volume/weight, and immune cell subset content. Composition of immune cells in blood and spleen of MT and MTG-CS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4966f5bc3a991561c45cd11aa6dd401f
https://doi.org/10.1158/2767-9764.22546768

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Data from Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b701a55c408a41306b8541cf640048d
https://doi.org/10.1158/2767-9764.c.6551242

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Supplementary Figures from Dysregulated Hematopoiesis Caused by Mammary Cancer Is Associated with Epigenetic Changes and Hox Gene Expression in Hematopoietic Cells

Autor: Kenneth W. Harder, Danielle L. Krebs, Tomasz Cierpicki, Jolanta Grembecka, Brad H. Nelson, Morgan E. Roberts, Xueling Fan, Kevin Tsai, Manreet K. Chehal, Alexander Sio

PDF file, 353K, Supplemental Figure S1: Mammary tumors induce significant changes in granulocyte and monocyte numbers in mice. Supplemental Figure S2: 4T1 tumor development is associated with impaired BM myelopoiesis and erythropoiesis, and disrupts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4ce2d9eb65c9dfb7f7e7efc3823b23
https://doi.org/10.1158/0008-5472.22396644.v1

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Data from Dysregulated Hematopoiesis Caused by Mammary Cancer Is Associated with Epigenetic Changes and Hox Gene Expression in Hematopoietic Cells

Autor: Kenneth W. Harder, Danielle L. Krebs, Tomasz Cierpicki, Jolanta Grembecka, Brad H. Nelson, Morgan E. Roberts, Xueling Fan, Kevin Tsai, Manreet K. Chehal, Alexander Sio

Cancer is associated with immune dysfunction characterized by the presence of proinflammatory and immunosuppressive cells and factors that contribute to tumor growth and progression. Here we show that mammary tumor growth is associated with defects i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1ab1d44a57173c59ef8c3900f46865
https://doi.org/10.1158/0008-5472.c.6504621

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Akademický článek

2B4-SAP signaling is required for the priming of naive CD8+ T cells by antigen-expressing B cells and B lymphoma cells

Autor: Yu-Hsuan Huang, Kevin Tsai, Sara Y. Tan, Sohyeong Kang, Mandy L. Ford, Kenneth W. Harder, John J. Priatel

Publikováno v: OncoImmunology, Vol 6, Iss 2 (2017)

Mutations in SH2D1A gene that encodes SAP (SLAM-associated protein) result in X-linked lymphoproliferative disease (XLP), a rare primary immunodeficiency disease defined by exquisite sensitivity to the B-lymphotropic Epstein–Barr virus (EBV) and B

Externí odkaz: https://doaj.org/article/2405c3bffb9645f58ec9b7df554d41d9

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