Zobrazeno 1 - 10
of 2 517
pro vyhledávání: '"W, Hancock"'
Autor:
David Martino, Nina Kresoje, Nelly Amenyogbe, Rym Ben-Othman, Bing Cai, Mandy Lo, Olubukola Idoko, Oludare A. Odumade, Reza Falsafi, Travis M. Blimkie, Andy An, Casey P. Shannon, Sebastiano Montante, Bhavjinder K. Dhillon, Joann Diray-Arce, Al Ozonoff, Kinga K. Smolen, Ryan R. Brinkman, Kerry McEnaney, Asimenia Angelidou, Peter Richmond, Scott J. Tebbutt, the EPIC-HIPC consortium, Beate Kampmann, Ofer Levy, Robert E. W. Hancock, Amy H. Y. Lee, Tobias R. Kollmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Understanding of newborn immune ontogeny in the first week of life will enable age-appropriate strategies for safeguarding vulnerable newborns against infectious diseases. Here we conducted an observational study exploring the immunological
Externí odkaz:
https://doaj.org/article/f8167ccffdeb4b0d9144c24cdeaf6fcb
Autor:
Mario Fidanza, Julie Hibbert, Erica Acton, Danny Harbeson, Elizna Schoeman, Patrycja Skut, Tabitha Woodman, Adrien Eynaud, Lucy Hartnell, Byron Brook, Bing Cai, Mandy Lo, Reza Falsafi, Robert E. W. Hancock, Msandeni Chiume-Kayuni, Norman Lufesi, Constantin R. Popescu, Pascal M. Lavoie, Tobias Strunk, Andrew J. Currie, Tobias R. Kollmann, Nelly Amenyogbe, Amy H. Lee
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Neonatal sepsis is a major cause of childhood mortality. Limited diagnostic tools and mechanistic insights have hampered our abilities to develop prophylactic or therapeutic interventions. Biomarkers in human neonatal sepsis have been repeat
Externí odkaz:
https://doaj.org/article/b54f31f4736543a6a2fa9c599d17c04a
Autor:
Tatiana Akimova, Liqing Wang, Zhanna Bartosh, Lanette M. Christensen, Evgeniy Eruslanov, Sunil Singhal, Veenu Aishwarya, Wayne W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Our goal is to improve the outcomes of cancer immunotherapy by targeting FOXP3+ T-regulatory (Treg) cells with a next generation of antisense oligonucleotides (ASO), termed FOXP3 AUMsilence ASO. We performed in vitro experiments with human healthy do
Externí odkaz:
https://doaj.org/article/a96f23f9055b414882bcdbc8711caf2b
Autor:
Lanette M. Christensen, Tatiana Akimova, Liqing Wang, Rongxiang Han, Arabinda Samanta, Eros Di Giorgio, Wayne W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Histone deacetylases 1 and 2 play a major role in the transcriptional regulation of T-regulatory (Treg) cells via interactions with a myriad of coregulatory factors. Sin3a has been well established as a Hdac1/2 cofactor, while its role within Tregs h
Externí odkaz:
https://doaj.org/article/ce5b2e2a49e74bcd86d6e921a8749fc3
Autor:
Rajan M Thomas, Matthew C Pahl, Liqing Wang, Struan FA Grant, Wayne W Hancock, Andrew D Wells
Publikováno v:
eLife, Vol 12 (2024)
Ikaros is a transcriptional factor required for conventional T cell development, differentiation, and anergy. While the related factors Helios and Eos have defined roles in regulatory T cells (Treg), a role for Ikaros has not been established. To det
Externí odkaz:
https://doaj.org/article/ba76a93665e24702a7a850571913d233
Publikováno v:
Physical Review Accelerators and Beams, Vol 27, Iss 8, p 081302 (2024)
Hydrodynamic plasma waveguides initiated by optical field ionization have recently become a key component of multi-GeV laser wakefield accelerators. Here, we present the most complete and accurate experimental and simulation-based characterization to
Externí odkaz:
https://doaj.org/article/194fa0ba4409425d8a6641955d77a844
Autor:
Elad Lax, Sonia Do Carmo, Yehoshua Enuka, Daniel M. Sapozhnikov, Lindsay A. Welikovitch, Niaz Mahmood, Shafaat A. Rabbani, Liqing Wang, Jonathan P. Britt, Wayne W. Hancock, Yosef Yarden, Moshe Szyf
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The Methyl-CpG-Binding Domain Protein family has been implicated in neurodevelopmental disorders. The Methyl-CpG-binding domain 2 (Mbd2) binds methylated DNA and was shown to play an important role in cancer and immunity. Some evidence linke
Externí odkaz:
https://doaj.org/article/ac756fae07a44e51b83b8e00c01221ca
Autor:
Dan Wang, Yingying Yue, He Liu, Tian Zhang, Evan F. Haney, Robert E. W. Hancock, Jian Yu, Ya Shen
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2024)
Titanium alloys have gained popularity in implant dentistry for the restoration of missing teeth and related hard tissues because of their biocompatibility and enhanced strength. However, titanium corrosion and infection caused by microbial biofilms
Externí odkaz:
https://doaj.org/article/d225993767144d9781d0b56f2e2f8b4e
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
RationaleSarcoidosis is an inflammatory granulomatous disease of unknown etiology with predominant lung involvement. Organ involvement and disease severity, as well as the nature of immune alterations, vary among patients leading to a range of clinic
Externí odkaz:
https://doaj.org/article/0cc69c9fb4d74a2996c9ab15a543d054
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
In 2007, the University of British Columbia (UBC) was the first university in Canada to establish and adopt global access (GA) principles. Toward implementing these principles, UBC then identified a set of strategies for providing affordable access t
Externí odkaz:
https://doaj.org/article/76cda94a968348619acf61fc8adfab36