Zobrazeno 1 - 10
of 163
pro vyhledávání: '"W, Gommeren"'
Autor:
Walter Luyten, Eckhard Bender, Josée E. Leysen, Ilse Van den Wyngaert, W. Gommeren, Mirek Jurzak, Peter Verhasselt
Publikováno v:
Journal of Neurochemistry. 69:1810-1819
Using a combination of library screening and nested PCR based on a partial human serotonin 5-HT 4 receptor sequence, we have cloned the complete coding region for a human 5-HT 4 receptor. The sequence shows extensive similarity to the published porci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3b02e01daa919577cab042edf0852a
https://doi.org/10.1046/j.1471-4159.1997.69051810.x
https://doi.org/10.1046/j.1471-4159.1997.69051810.x
Autor:
Walter Luyten, W. Gommeren, I van Oers, Armelle Nathalie Françoise Pindon, Peter Verhasselt, YB Zhang, Mirek Jurzak, J. E. Leysen, Eckhard Bender
Publikováno v:
Journal of Neurochemistry. 74:478-489
Several variants of the serotonin 5-HT 4 receptor are known to be produced by alternative splicing. To survey the existence and usage of exons in humans, we cloned the human 5-HT 4 gene. Based on sequence analysis seven C-terminal variants (a-g) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e271bc8fdaf3860dd9d186af0cf75d45
https://doi.org/10.1046/j.1471-4159.2000.740478.x
https://doi.org/10.1046/j.1471-4159.2000.740478.x
Autor:
Walter Luyten, Xavier Langlois, M. Paola Castelli, W. Gommeren, Gian Luigi Gessa, Ignazia Mocci, Josée E. Leysen
Publikováno v:
Molecular Brain Research. 78:91-99
γ-Hydroxybutyric acid (GHB), a naturally occurring metabolite of GABA, is present in micromolar concentrations in various areas of the mammalian brain. Specific GHB binding sites, uptake system, synthetic and metabolizing enzymes have been identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2f85591ed79404fb31e5c46d82b599
https://doi.org/10.1016/s0169-328x(00)00078-4
https://doi.org/10.1016/s0169-328x(00)00078-4
Publikováno v:
European Neuropsychopharmacology. 6:S4-120
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fc4d478107c0277371042dc48c83d79
https://doi.org/10.1016/0924-977x(96)82945-2
https://doi.org/10.1016/0924-977x(96)82945-2
Autor:
K. De Loore, A. Schotte, J. E. Leysen, A S Lesage, P. Van Gompel, W. Gommeren, P.F.M. Janssen, Walter Luyten
Publikováno v:
Psychopharmacology. 124:57-73
Risperidone and its active metabolite 9-OH-risperidone were compared to reference antipsychotic drugs (haloperidol, pipamperone, fluspirilene, clozapine, zotepine) and compounds under development (olanzapine, seroquel, sertindole, ORG-5222, ziprasido
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91cf16c7f776691f29f4577362177266
https://doi.org/10.1007/bf02245606
https://doi.org/10.1007/bf02245606
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 34:795-806
4-Amino-N-[1-[3-(4-fluorophenoxy)propyl]-4-methyl-4-piperidinyl]-2-methoxy-benzamide, a compound with high affinity for 5HT2-receptors, was radioiodinated on the 2-position of the phenoxygroup or the 5-position of the methoxybenzamide group. The form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b9fa999dfa437f64ea7bf5bdc1b915e
https://doi.org/10.1002/jlcr.2580340902
https://doi.org/10.1002/jlcr.2580340902
Autor:
Peter H. Seeburg, J. Mertens, Walter Luyten, W. Gommeren, Petrus J. Pauwels, Markus Ewert, Josée E. Leysen
Publikováno v:
Psychopharmacology
We investigated the ligand binding properties in vitro of two splice variants of the cloned human dopamine D2 receptor (the 443 and 414 amino acids long forms called D2L and D2S, respectively), expressed in 293 human kidney cells, in comparison with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449d43c89c60844691288beed8963c8a
https://doi.org/10.1007/bf02246947
https://doi.org/10.1007/bf02246947
Publikováno v:
Drug Development Research. 22:165-178
A new antihistamine, noberastine, and clinically used non-sedating antihistamines, astemizole, mequitazine, terfenadine, loratadine, and cetirizine were investigated for in vitro and ex vivo binding to histamine-H1 receptors in guinea-pig cerebellums
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6664ce9d8b73e5b15dd3a4aefb3a2586
https://doi.org/10.1002/ddr.430220207
https://doi.org/10.1002/ddr.430220207
Publikováno v:
European Journal of Pharmacology. 218:373-375
[125I]Iodosulpride binding was studied in frontal rat brain sections by quantitative autoradiography. Using preincubated ( = washed) sections, selective labelling and identification of dopamine D3 receptors was obtained using 0.2 nM [125I]iodosulprid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41cc94ee059ddb4c36e0ed81782395dd
https://doi.org/10.1016/0014-2999(92)90196-b
https://doi.org/10.1016/0014-2999(92)90196-b
Publikováno v:
Molecular pharmacology. 57(6)
The 5-hydroxytryptamine (5-HT) 1D/1B receptors have gained particular interest as potential targets for treatment of migraine and depression. G-protein coupling and other intrinsic properties of the human 5-HT(1D) receptor were studied using a baculo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8f11448b2db2ca24bc84c99dee0299b
https://pubmed.ncbi.nlm.nih.gov/10825383
https://pubmed.ncbi.nlm.nih.gov/10825383