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of 372
pro vyhledávání: '"W, Cushman"'
Akademický článek
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Publikováno v:
BMC Public Health, Vol 16, Iss 1, Pp 1-12 (2016)
Abstract Background The aim of this study was to identify corresponding body mass index (BMI) and waist circumference cut-offs for equivalent levels of insulin sensitivity in a Middle Eastern immigrant population compared with native Swedes. Methods
Externí odkaz:
https://doaj.org/article/41e1478ade134d2eaf02a35eb0361d9a
Autor:
Candice A. Allister, Li-fen Liu, Cindy A. Lamendola, Colleen M. Craig, Samuel W. Cushman, Marc K. Hellerstein, Tracey L. McLaughlin
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 2, Pp 435-439 (2015)
Indirect evidence suggests that impaired triglyceride storage in the subcutaneous fat depot contributes to the development of insulin resistance via lipotoxicity. We directly tested this hypothesis by measuring, in vivo, TG synthesis, de novo lipogen
Externí odkaz:
https://doaj.org/article/8bb695155aea4d78afaae84528e33b52
Autor:
Li Fen Liu, Colleen M Craig, Lorna L Tolentino, Okmi Choi, John Morton, Homero Rivas, Samuel W Cushman, Edgar G Engleman, Tracey McLaughlin
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170728 (2017)
AIM:The physiologic mechanisms underlying the relationship between obesity and insulin resistance are not fully understood. Impaired adipocyte differentiation and localized inflammation characterize adipose tissue from obese, insulin-resistant humans
Externí odkaz:
https://doaj.org/article/32aeb8c8d27e4a08a2e885651ba423ef
Autor:
Vladimir A Lizunov, Karin G Stenkula, Paul S Blank, Aaron Troy, Jo-Ping Lee, Monica C Skarulis, Samuel W Cushman, Joshua Zimmerberg
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119291 (2015)
While intercellular communication processes are frequently characterized by switch-like transitions, the endocrine system, including the adipose tissue response to insulin, has been characterized by graded responses. Yet here individual cells from ad
Externí odkaz:
https://doaj.org/article/1e1e9dc6c25b42e5a36f4f9e327f68ea
Autor:
Georgeta Crivat, Vladimir A Lizunov, Caroline R Li, Karin G Stenkula, Joshua Zimmerberg, Samuel W Cushman, Leslie Pick
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e77953 (2013)
The fruit fly Drosophila melanogaster is an excellent model system for studies of genes controlling development and disease. However, its applicability to physiological systems is less clear because of metabolic differences between insects and mammal
Externí odkaz:
https://doaj.org/article/318f31fbc7834aa38afafeb7cb206ed4
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57559 (2013)
Insulin-stimulated delivery of glucose transporter-4 (GLUT4) to the plasma membrane (PM) is the hallmark of glucose metabolism. In this study we examined insulin's effects on GLUT4 organization in PM of adipose cells by direct microscopic observation
Externí odkaz:
https://doaj.org/article/5942b6b611b546c6b2ca6d2c8354c9a7
Autor:
F B Kraemer, S A Sather, B Park, C Sztalryd, V Natu, K May, H Nishimura, I Simpson, A D Cooper, S W Cushman
Publikováno v:
Journal of Lipid Research, Vol 35, Iss 10, Pp 1760-1772 (1994)
The distribution of LDL receptors within subcellular compartments of isolated rat adipose cells and the effects of insulin on their expression have been assessed. By immunoblotting with specific anti-rat LDL receptor antibodies, LDL receptors were 2.
Externí odkaz:
https://doaj.org/article/e86304d886ed442ea7220736336b0392
Akademický článek
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Autor:
Bernie J Daigle, Alicia Deng, Tracey McLaughlin, Samuel W Cushman, Margaret C Cam, Gerald Reaven, Philip S Tsao, Russ B Altman
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 3, p e1000718 (2010)
Although they have become a widely used experimental technique for identifying differentially expressed (DE) genes, DNA microarrays are notorious for generating noisy data. A common strategy for mitigating the effects of noise is to perform many expe
Externí odkaz:
https://doaj.org/article/ccfec585f80e4b68a51bbcf6f883b6e6