Zobrazeno 1 - 10
of 119
pro vyhledávání: '"W, Craig Johnson"'
Autor:
Alana C. Jones, Amit Patki, Vinodh Srinivasasainagendra, Bertha A. Hidalgo, Hemant K. Tiwari, Nita A. Limdi, Nicole D. Armstrong, Ninad S. Chaudhary, Bré Minniefield, Devin Absher, Donna K. Arnett, Leslie A. Lange, Ethan M. Lange, Bessie A. Young, Clarissa J. Diamantidis, Stephen S. Rich, Josyf C. Mychaleckyj, Jerome I. Rotter, Kent D. Taylor, Holly J. Kramer, Russell P. Tracy, Peter Durda, Silva Kasela, Tuuli Lappalinen, Yongmei Liu, W. Craig Johnson, David J. Van Den Berg, Nora Franceschini, Simin Liu, Charles P. Mouton, Parveen Bhatti, Steve Horvath, Eric A. Whitsel, Marguerite R. Irvin
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Chronic kidney disease (CKD) impacts about 1 in 7 adults in the United States, but African Americans (AAs) carry a disproportionately higher burden of disease. Epigenetic modifications, such as DNA methylation at cytosine-phosphate-guanine (
Externí odkaz:
https://doaj.org/article/12deb3d0ae334de99921176e9c1f291a
Autor:
Kent D. Taylor, Alexis C. Wood, Jerome I. Rotter, Xiuqing Guo, David M. Herrington, W. Craig Johnson, Wendy S. Post, Russell P. Tracy, Stephen S. Rich, Shaista Malik
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 19 (2024)
Background Inflammation is a feature of coronary heart disease (CHD), but the role of proinflammatory microbial infection in CHD remains understudied. Methods and Results CHD was defined in the MESA (Multi‐Ethnic Study of Atherosclerosis) as myocar
Externí odkaz:
https://doaj.org/article/d6727c8340ab42e88396ccacf2804528
Autor:
Xiaowei Hu, Jeongok G. Logan, Younghoon Kwon, Joao A. C. Lima, David R. Jacobs, Daniel Duprez, Lyndia Brumback, Kent D. Taylor, Peter Durda, W. Craig Johnson, Elaine Cornell, Xiuqing Guo, Yongmei Liu, Russell P. Tracy, Thomas W. Blackwell, George Papanicolaou, Gary F. Mitchell, Stephen S. Rich, Jerome I. Rotter, David J. Van Den Berg, Julio A. Chirinos, Timothy M. Hughes, Francine E. Garrett-Bakelman, Ani Manichaikul
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Despite the prognostic value of arterial stiffness (AS) and pulsatile hemodynamics (PH) for cardiovascular morbidity and mortality, epigenetic modifications that contribute to AS/PH remain unknown. To gain a better understanding of the link
Externí odkaz:
https://doaj.org/article/2566eec7931e4736bf4aa961b170b4a1
Autor:
Taibo Li, Nicole Ferraro, Benjamin J. Strober, Francois Aguet, Silva Kasela, Marios Arvanitis, Bohan Ni, Laurens Wiel, Elliot Hershberg, Kristin Ardlie, Dan E. Arking, Rebecca L. Beer, Jennifer Brody, Thomas W. Blackwell, Clary Clish, Stacey Gabriel, Robert Gerszten, Xiuqing Guo, Namrata Gupta, W. Craig Johnson, Tuuli Lappalainen, Henry J. Lin, Yongmei Liu, Deborah A. Nickerson, George Papanicolaou, Jonathan K. Pritchard, Pankaj Qasba, Ali Shojaie, Josh Smith, Nona Sotoodehnia, Kent D. Taylor, Russell P. Tracy, David Van Den Berg, Matthew T. Wheeler, Stephen S. Rich, Jerome I. Rotter, Alexis Battle, Stephen B. Montgomery
Publikováno v:
Cell Genomics, Vol 3, Iss 10, Pp 100401- (2023)
Summary: Each human genome has tens of thousands of rare genetic variants; however, identifying impactful rare variants remains a major challenge. We demonstrate how use of personal multi-omics can enable identification of impactful rare variants by
Externí odkaz:
https://doaj.org/article/d2548cee9ef64b4fa282cb83949a4d84
Autor:
Kristina L. Buschur, Craig Riley, Aabida Saferali, Peter Castaldi, Grace Zhang, Francois Aguet, Kristin G. Ardlie, Peter Durda, W. Craig Johnson, Silva Kasela, Yongmei Liu, Ani Manichaikul, Stephen S. Rich, Jerome I. Rotter, Josh Smith, Kent D. Taylor, Russell P. Tracy, Tuuli Lappalainen, R. Graham Barr, Frank Sciurba, Craig P. Hersh, Panayiotis V. Benos
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Chronic obstructive pulmonary disease (COPD) varies significantly in symptomatic and physiologic presentation. Identifying disease subtypes from molecular data, collected from easily accessible blood samples, can help stratify pat
Externí odkaz:
https://doaj.org/article/2432ac0f1e9a4ee08f8823576baf8705
Autor:
Usman A. Tahir, Daniel H. Katz, Julian Avila-Pachecho, Alexander G. Bick, Akhil Pampana, Jeremy M. Robbins, Zhi Yu, Zsu-Zsu Chen, Mark D. Benson, Daniel E. Cruz, Debby Ngo, Shuliang Deng, Xu Shi, Shuning Zheng, Aaron S. Eisman, Laurie Farrell, Michael E. Hall, Adolfo Correa, Russell P. Tracy, Peter Durda, Kent D. Taylor, Yongmei Liu, W. Craig Johnson, Xiuqing Guo, Jie Yao, Yii-Der Ida Chen, Ani W. Manichaikul, Frederick L. Ruberg, William S. Blaner, Deepti Jain, NHLBI Trans-Omics for Precision Medicine 1 Consortium, Claude Bouchard, Mark A. Sarzynski, Stephen S. Rich, Jerome I. Rotter, Thomas J. Wang, James G. Wilson, Clary B. Clish, Pradeep Natarajan, Robert E. Gerszten
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Most studies of the genetics of the metabolome have been done in individuals of European descent. Here, the authors integrate genomics and metabolomics in Black individuals, highlighting the value of whole genome sequencing in diverse populations and
Externí odkaz:
https://doaj.org/article/380bd0e319184fc38c71a20658080839
Autor:
Ani Manichaikul, Honghuang Lin, Chansuk Kang, Chaojie Yang, Stephen S. Rich, Kent D. Taylor, Xiuqing Guo, Jerome I. Rotter, W. Craig Johnson, Elaine Cornell, Russell P. Tracy, J. Peter Durda, Yongmei Liu, Ramachandran S. Vasan, L. Adrienne Cupples, Robert E. Gerszten, Clary B. Clish, Deepti Jain, Matthew P. Conomos, Thomas Blackwell, George J. Papanicolaou, Annabelle Rodriguez
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Rodriguez et al. use whole genome sequencing and plasma proteomics from the Multi-Ethnic Study of Atherosclerosis (MESA) and the Framingham Heart Study (FHS) cohorts of the Trans-Omics for Precision Medicine program and perform in situ Hi-C chromatin
Externí odkaz:
https://doaj.org/article/45f18806e0784352b92136429a1f97c1
Autor:
Heming Wang, Nuzulul Kurniansyah, Brian E. Cade, Matthew O. Goodman, Han Chen, Daniel J. Gottlieb, Sina A. Gharib, Shaun M. Purcell, Xihong Lin, Richa Saxena, Xiaofeng Zhu, Peter Durda, Russel Tracy, Yongmei Liu, Kent D. Taylor, W. Craig Johnson, Stacey Gabriel, Joshua D. Smith, François Aguet, Kirstin Ardlie, Tom Blackwell, Alexander P. Reiner, Jerome I. Rotter, Stephen S. Rich, TOPMed Sleep Traits Working Group, Susan Redline, Tamar Sofer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Obstructive sleep apnea (OSA) is a common disorder associated with increased risk of cardiovascular disease and mortality. Iron and heme metabolism, implicated in ventilatory control and OSA comorbidities, was associated with OSA phenotypes
Externí odkaz:
https://doaj.org/article/62b4f545db4c4e05b989b6e8ef7f69e8
Autor:
Xutong Zhao, Dandi Qiao, Chaojie Yang, Silva Kasela, Wonji Kim, Yanlin Ma, Nick Shrine, Chiara Batini, Tamar Sofer, Sarah A. Gagliano Taliun, Phuwanat Sakornsakolpat, Pallavi P. Balte, Dmitry Prokopenko, Bing Yu, Leslie A. Lange, Josée Dupuis, Brian E. Cade, Jiwon Lee, Sina A. Gharib, Michelle Daya, Cecelia A. Laurie, Ingo Ruczinski, L. Adrienne Cupples, Laura R. Loehr, Traci M. Bartz, Alanna C. Morrison, Bruce M. Psaty, Ramachandran S. Vasan, James G. Wilson, Kent D. Taylor, Peter Durda, W. Craig Johnson, Elaine Cornell, Xiuqing Guo, Yongmei Liu, Russell P. Tracy, Kristin G. Ardlie, François Aguet, David J. VanDenBerg, George J. Papanicolaou, Jerome I. Rotter, Kathleen C. Barnes, Deepti Jain, Deborah A. Nickerson, Donna M. Muzny, Ginger A. Metcalf, Harshavardhan Doddapaneni, Shannon Dugan-Perez, Namrata Gupta, Stacey Gabriel, Stephen S. Rich, George T. O’Connor, Susan Redline, Robert M. Reed, Cathy C. Laurie, Martha L. Daviglus, Liana K. Preudhomme, Kristin M. Burkart, Robert C. Kaplan, Louise V. Wain, Martin D. Tobin, Stephanie J. London, Tuuli Lappalainen, Elizabeth C. Oelsner, Goncalo R. Abecasis, Edwin K. Silverman, R. Graham Barr, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Lung Working Group, Michael H. Cho, Ani Manichaikul
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Chronic obstructive pulmonary disease is a leading cause of morbidity and mortality. Here, the authors analyse whole genome sequence data and find new loci associated with lung function and COPD.
Externí odkaz:
https://doaj.org/article/766c14dc6e2e403ab99c3712ee01a263
Autor:
Ryan Schubert, Elyse Geoffroy, Isabelle Gregga, Ashley J. Mulford, Francois Aguet, Kristin Ardlie, Robert Gerszten, Clary Clish, David Van Den Berg, Kent D. Taylor, Peter Durda, W. Craig Johnson, Elaine Cornell, Xiuqing Guo, Yongmei Liu, Russell Tracy, Matthew Conomos, Tom Blackwell, George Papanicolaou, Tuuli Lappalainen, Anna V. Mikhaylova, Timothy A. Thornton, Michael H. Cho, Christopher R. Gignoux, Leslie Lange, Ethan Lange, Stephen S. Rich, Jerome I. Rotter, NHLBI TOPMed Consortium, Ani Manichaikul, Hae Kyung Im, Heather E. Wheeler
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Genetically regulated gene expression has helped elucidate the biological mechanisms underlying complex traits. Improved high-throughput technology allows similar interrogation of the genetically regulated proteome for understanding complex trait mec
Externí odkaz:
https://doaj.org/article/1c31951b7a40468b853b12770596b9bf