Zobrazeno 1 - 10
of 536
pro vyhledávání: '"W, Chia"'
Autor:
Cecily Choy, Joseph Chen, Jiangyuan Li, D. Travis Gallagher, Jian Lu, Daichao Wu, Ainslee Zou, Humza Hemani, Beverly A. Baptiste, Emily Wichmann, Qian Yang, Jeffrey Ciffelo, Rui Yin, Julia McKelvy, Denise Melvin, Tonya Wallace, Christopher Dunn, Cuong Nguyen, Chee W. Chia, Jinshui Fan, Jeannie Ruffolo, Linda Zukley, Guixin Shi, Tomokazu Amano, Yang An, Osorio Meirelles, Wells W. Wu, Chao-Kai Chou, Rong-Fong Shen, Richard A. Willis, Minoru S. H. Ko, Yu-Tsueng Liu, Supriyo De, Brian G. Pierce, Luigi Ferrucci, Josephine Egan, Roy Mariuzza, Nan-Ping Weng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8+ T cells play a vital role. Nonetheless, the characterization of the specificity and TCR composition of CD8+ T cells targeting non-spike protein of SARS-C
Externí odkaz:
https://doaj.org/article/963224e732b44fa8b3d0805dabc27063
Autor:
Grant Schumock, Karen Bandeen-Roche, Chee W Chia, Rita R Kalyani, Luigi Ferrucci, Ravi Varadhan
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0302381 (2024)
As people age, their ability to maintain homeostasis in response to stressors diminishes. Physical frailty, a syndrome characterized by loss of resilience to stressors, is thought to emerge due to dysregulation of and breakdowns in communication amon
Externí odkaz:
https://doaj.org/article/9cadfc18de814abbad9093aa3fe00ca1
Autor:
Jian Lu, Raheel Ahmad, Thomas Nguyen, Jeffrey Cifello, Humza Hemani, Jiangyuan Li, Jinguo Chen, Siyi Li, Jing Wang, Achouak Achour, Joseph Chen, Meagan Colie, Ana Lustig, Christopher Dunn, Linda Zukley, Chee W. Chia, Irina Burd, Jun Zhu, Luigi Ferrucci, Nan-ping Weng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The characterisation of T cells during aging is important to predict functional outcomes in vaccination or infection. Here the authors use flow cytometry and scRNA sequencing to transcriptionally age CD8 T cells and then use a machine learning model
Externí odkaz:
https://doaj.org/article/06820e5848b3446782b42bbc3c749de7
Autor:
Xiaoping Sun, Thomas Nguyen, Achouak Achour, Annette Ko, Jeffrey Cifello, Chen Ling, Jay Sharma, Toyoko Hiroi, Yongqing Zhang, Chee W. Chia, William Wood III, Wells W. Wu, Linda Zukley, Je-Nie Phue, Kevin G. Becker, Rong-Fong Shen, Luigi Ferrucci, Nan-ping Weng
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 17 (2022)
A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of pathogens, and TCR repertoire size is believed to decline with age. However, the precise size of human TCR repertoires, in both total and subsets of T cells,
Externí odkaz:
https://doaj.org/article/be9e3fbb629f4693b28c5ccd2679bf6e
Autor:
Robert A. Tumasian, Abhinav Harish, Gautam Kundu, Jen-Hao Yang, Ceereena Ubaida-Mohien, Marta Gonzalez-Freire, Mary Kaileh, Linda M. Zukley, Chee W. Chia, Alexey Lyashkov, William H. Wood, Yulan Piao, Christopher Coletta, Jun Ding, Myriam Gorospe, Ranjan Sen, Supriyo De, Luigi Ferrucci
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
As human skeletal muscle ages, gene expression programs change and reflect damage accumulation and homeostatic resilience mechanisms. Here, the authors present a detailed framework of the global transcriptome that characterizes skeletal muscle during
Externí odkaz:
https://doaj.org/article/fe1b133469394d2ea2f9de8c7479f7a6
Autor:
Karen S. W. Chia, Christine T. Shiner, Karen Brown, Cameron J. Holloway, Camila Moreyra, Nicole Bart, Peter K. K. Wong, Steven G. Faux, Eugene Kotlyar
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 2, Pp n/a-n/a (2022)
Abstract Pulmonary hypertension (PH) is characterized by progressive dyspnea, fatigue, and reduced exercise capacity. Despite medical treatment, outcomes remain poor. While exercise training is well established in patients with heart failure, it is l
Externí odkaz:
https://doaj.org/article/c5e8d2cda8c842e58b92e905f96f7b1d
Autor:
B. E. Fan, S. W. Wong, C. L. L. Sum, G. H. Lim, B. P. Leung, R. Dalan, B. E. Young, D. C. Lye, C. Cheung, K. Ramanathan, C. W. Tan, E. S. Yap, Y. W. Chia
Publikováno v:
HemaSphere, Vol 6, Pp 1564-1565 (2022)
Externí odkaz:
https://doaj.org/article/28f2ee93306c4333b7dc76a7f8a07d7d
Publikováno v:
Endocrinology and Metabolism Clinics of North America. 52:295-315
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::113d67a957771c613c6027d3f6c4f8a2
https://doi.org/10.1016/j.ecl.2022.10.002
https://doi.org/10.1016/j.ecl.2022.10.002
Autor:
Curtis Tilves, Toshiko Tanaka, Moira K. Differding, Adam P. Spira, Chee W. Chia, Luigi Ferrucci, Noel T. Mueller
Publikováno v:
Obesity. 31:1425-1435
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df2e3f43746bbddcd8374465257c2ca5
https://doi.org/10.1002/oby.23717
https://doi.org/10.1002/oby.23717
Attitudes towards exercise among medical specialists who manage patients with pulmonary hypertension
Autor:
Karen S. W. Chia, Peter K. K. Wong, Senen Gonzalez, Eugene Kotlyar, Steven G. Faux, Christine T. Shiner
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Exercise training was not traditionally recommended for patients with pulmonary hypertension. However, recent work has demonstrated that exercise improves endurance and quality-of-life in patients with pulmonary hypertension. Unfortunately, patients
Externí odkaz:
https://doaj.org/article/0bfac6fc5de1487f9cf4e7ba19475822