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Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1

Autor: Hwei Ling Ong, Xibao Liu, So-ching W. Brazer, Indu S. Ambudkar, Kristina Rauser, Brij B. Singh, Biswaranjan Pani

Publikováno v: Proceedings of the National Academy of Sciences. 106:20087-20092

Store-operated Ca 2+ entry (SOCE) is activated by redistribution of STIM1 into puncta in discrete ER-plasma membrane junctional regions where it interacts with and activates store-operated channels (SOCs). The factors involved in precise targeting of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21d958a9021001aa6925a8064949d1a
https://doi.org/10.1073/pnas.0905002106

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Canonical Transient Receptor Potential 1 Plays a Role in Basic Fibroblast Growth Factor (bFGF)/FGF Receptor-1-Induced Ca2+ Entry and Embryonic Rat Neural Stem Cell Proliferation

Autor: Jeffery L. Barker, Yoong H. Chang, Dragan Maric, Alessandra Fiorio Pla, Paolo Giacobini, Xibao Liu, Indu S. Ambudkar, So-ching W. Brazer

Publikováno v: The Journal of Neuroscience. 25:2687-2701

Basic fibroblast growth factor (bFGF) and its major receptor FGF receptor-1 (FGFR-1) play an important role in the development of the cortex. The mechanisms underlying the mitogenic role of bFGF/FGFR-1 signaling have not been elucidated. Intracellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c711e82d8d728e1bbd39c5c26ad794ac
https://doi.org/10.1523/jneurosci.0951-04.2005

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Caveolin-1 Contributes to Assembly of Store-operated Ca2+ Influx Channels by Regulating Plasma Membrane Localization of TRPC1

Autor: Xibao Liu, William D. Swaim, Brij B. Singh, So-ching W. Brazer, Indu S. Ambudkar

Publikováno v: Journal of Biological Chemistry. 278:27208-27215

TRPC1, a component of store-operated Ca2+ entry (SOCE) channels, is assembled in a complex with caveolin-1 (Cav1) and key Ca2+ signaling proteins. This study examines the role of Cav1 in the function of TRPC1. TRPC1 and Cav1 were colocalized in the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21cc430419ee78911ffaa3633b69c485
https://doi.org/10.1074/jbc.m301118200

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A fission yeast kinesin affects Golgi membrane recycling

Autor: W. Zacheus Cande, Hazel P. Williams, So-Ching W. Brazer, Thomas G. Chappell

Publikováno v: Yeast. 16:149-166

We report here an in vivo study of kinesin heavy chain (KHC) functions in yeast. We have identified in Schizosaccharomyces pombe a kinesin motor gene, klp3(+), which has the highest homology to the Neurospora crassa KHC. Using indirect immunofluoresc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1c846245cab70cec8bad1a92db9af5f
https://doi.org/10.1002/(sici)1097-0061(20000130)16:2<149::aid-yea514>3.0.co

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Reciprocal Desensitization of CCR5 and CD4 Is Mediated by IL-16 and Macrophage-Inflammatory Protein-1β, Respectively

Autor: M. Vallen Mashikian, T. C. Ryan, A. Seman, W. Brazer, D. M. Center, W. W. Cruikshank

Publikováno v: The Journal of Immunology. 163:3123-3130

The ability of HIV-1 gp120 to inhibit chemokine signaling prompted us to determine whether signaling through CD4 by a natural ligand, IL-16, could alter cellular responsiveness to chemokine stimulation. These studies demonstrate that IL-16/CD4 signal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abf9ae29d27a06a541ef0e4e7fb6404d
https://doi.org/10.4049/jimmunol.163.6.3123

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Polarized Type 1 Cytokine Profile in Bronchoalveolar Lavage T Cells of Patients with Hypersensitivity Pneumonitis

Autor: H, Yamasaki, M, Ando, W, Brazer, D M, Center, W W, Cruikshank

Publikováno v: The Journal of Immunology. 163:3516-3523

Hypersensitivity pneumonitis (HP) is characterized by an inflammatory lymphocytic alveolitis comprised of both CD8+ and CD4+ T cells. Animal models suggest that HP is facilitated by overproduction of IFN-γ, and that IL-10 ameliorates severity of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2a04b61cd93b7a172153e4c177d8bb
https://doi.org/10.4049/jimmunol.163.6.3516

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Plasma Membrane Localization of TRPC Channels: Role of Caveolar Lipid Rafts

Autor: Brij B. Singh, Timothy Lockwich, Indu S. Ambudkar, So-ching W. Brazer, Xibao Liu

Publikováno v: Mammalian TRP Channels as Molecular Targets: Novartis Foundation Symposium 258

GPCR-mediated activation of the Ca2+ signalling cascade leads to stimulation of Ca2+ influx into non-excitable cells. Both store-dependent and independent channels likely contribute towards this Ca2+ influx. However, the identity of the channels and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::375ecec2a4622e716d87e353f8a151f5
https://doi.org/10.1002/0470862580.ch5

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Reciprocal desensitization of CCR5 and CD4 is mediated by IL-16 and macrophage-inflammatory protein-1 beta, respectively

Autor: M V, Mashikian, T C, Ryan, A, Seman, W, Brazer, D M, Center, W W, Cruikshank

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1d654109250166e0978584e98b43a74
https://pubmed.ncbi.nlm.nih.gov/10477578

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