Detection of cutaneous oxygen saturation using a novel snapshot hyperspectral camera: A feasibility study

Autor: Roger S. Wilson, Jeroen Eggermont, Labrinus van Manen, W. Birkhoff, J. Sven D. Mieog, Michelle S. Bradbury, Philip J. Nicklin, Alexander L. Vahrmeijer, Jouke Dijkstra, Richelle J. M. Hoveling, Dominic J. Robinson, Jacobus Burggraaf

Publikováno v: Quantitative imaging in medicine and surgery, 11(9), 3966-3977. AME Publishing Company
Quantitative Imaging in Medicine and Surgery, 11(9), 3966-3977. AME PUBL CO
Quant Imaging Med Surg
Quantitative Imaging in Medicine and Surgery, 11(9), 3966-3977. AME Publishing Company

BACKGROUND: Tissue necrosis, a consequence of inadequate tissue oxygenation, is a common post-operative complication. As current surgical assessments are often limited to visual and tactile feedback, additional techniques that can aid in the interrog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a17a0177eaad1e6f1344aef032744c
https://doi.org/10.21037/qims-21-46

Retinal oximetry and fractal analysis of capillary maps in sickle cell disease patients and matched healthy volunteers

Autor: M L De Kam, J C van Meurs, L. van Manen, Adam F. Cohen, W. Birkhoff, Jouke Dijkstra

Publikováno v: Graefe's Archive for Clinical and Experimental Ophthalmology

Purpose Fractal analysis can be used to quantitatively analyze the retinal microvasculature and might be a suitable method to quantify retinal capillary changes in sickle cell disease (SCD) patients. Retinal oximetry measurements might function as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976025807d88ea7c650890a9f38792ee
http://hdl.handle.net/1887/121407

Levofloxacin-Induced QTc Prolongation Depends on the Time of Drug Administration

Autor: W. Birkhoff, Jacobus Burggraaf, Ingrid M. C. Kamerling, Jasper Stevens, Meindert Danhof, V. Gotta, Johanna H. Meijer, Laura Kervezee

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology. 5:466-474

Understanding the factors influencing a drug's potential to prolong the QTc interval on an electrocardiogram is essential for the correct evaluation of its safety profile. To explore the effect of dosing time on drug-induced QTc prolongation, a rando

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11c8ac540f6565d9b40655f6cd6b0c65
https://doi.org/10.1002/psp4.12085

The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy

Autor: Jules A. A. C. Heuberger, Eugenio Mercuri, Katja Heinig, Russell Kinch, Andreas Günther, Irene Gerlach, Wakana Tang, Teodorica L. Bugawan, Omar Khwaja, Geert Jan Groeneveld, W. Birkhoff, Heidemarie Kletzl, Claire L Wood, Hanns Lochmüller, Sebastian Dziadek, Dirk Fischer, Christian Czech, Anne Marquet

Publikováno v: Neuromuscular disorders : NMD. 29(1)

Spinal muscular atrophy (SMA) is a rare genetic and progressively debilitating neuromuscular disease. It is the leading genetic cause of death among infants. In SMA, low levels of survival of motor neuron (SMN) protein lead to motor neuron death and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd3af212d2a80d491e04b1614b29a09
https://pubmed.ncbi.nlm.nih.gov/30553700

Colistin

Autor: Natalia V. Ortiz-Zacarias, Ingrid M C Kamerling, Erik B Wilms, Henri A. Verbrugh, Cees van Nieuwkoop, Anneke C. Dijkmans, Daan J Touw, W. Birkhoff

Publikováno v: Therapeutic Drug Monitoring, 37(4), 419-427
Therapeutic Drug Monitoring, 37(4), 419-427. Lippincott Williams & Wilkins

Colistin (polymyxin E) is a positively charged deca-peptide antibiotic that disrupts the integrity of the outer membrane of the cell wall of gram-negative bacteria by binding to the lipid A moiety of lipopolysaccharides, resulting in cell death. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2567d68522542bb52ba903b752692ab2
https://doi.org/10.1097/ftd.0000000000000172