ALG-2 participates in recovery of cells after plasma membrane damage by electroporation and digitonin treatment.

Autor: Jonas M la Cour, Pernille Winding Gojkovic, Sophie E B Ambjørner, Jonas Bagge, Simone M Jensen, Svetlana Panina, Martin W Berchtold

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0204520 (2018)

The calcium binding protein ALG-2 is upregulated in several types of cancerous tissues and cancer cell death may be a consequence of ALG-2 downregulation. Novel research suggests that ALG-2 is involved in membrane repair mechanisms, in line with seve

Externí odkaz: https://doaj.org/article/6b0f49f98dfd4383996f07061f2f3797

A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling

Autor: Noémie Alphonse, Joseph J. Wanford, Andrew A. Voak, Jack Gay, Shayla Venkhaya, Owen Burroughs, Sanjana Mathew, Truelian Lee, Sasha L. Evans, Weiting Zhao, Kyle Frowde, Abrar Alrehaili, Ruth E. Dickenson, Mads Munk, Svetlana Panina, Ishraque F. Mahmood, Miriam Llorian, Megan L. Stanifer, Steeve Boulant, Martin W. Berchtold, Julien R.C. Bergeron, Andreas Wack, Cammie F. Lesser, Charlotte Odendall

Publikováno v: Alphonse, N, Wanford, J J, Voak, A A, Gay, J, Venkhaya, S, Burroughs, O, Mathew, S, Lee, T, Evans, S L, Zhao, W, Frowde, K, Alrehaili, A, Dickenson, R E, Munk, M, Panina, S, Mahmood, I F, Llorian, M, Stanifer, M L, Boulant, S, Berchtold, M W, Bergeron, J R C, Wack, A, Lesser, C F & Odendall, C 2022, ' A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling ', Cell, vol. 185, no. 13, pp. 2354-2369.e17 . https://doi.org/10.1016/j.cell.2022.04.028

Interferons (IFNs) induce an antimicrobial state, protecting tissues from infection. Many viruses inhibit IFN signaling, but whether bacterial pathogens evade IFN responses remains unclear. Here, we demonstrate that the Shigella OspC family of type-I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83dc8d786ef3ddcd48631cca6451b6f4
https://curis.ku.dk/ws/files/312499015/1_s2.0_S0092867422005268_main.pdf

Sprifermin (rhFGF18) versus vehicle induces a biphasic process of extracellular matrix remodeling in human knee OA articular cartilage ex vivo

Autor: Thorbjørn Gantzel, D. Reker, Anne Sofie Siebuhr, Anders Aspberg, Anne-Christine Bay-Jensen, Morten A. Karsdal, Christoph Ladel, Anne Gigout, Christian S. Thudium, M. Michaelis, M. W. Berchtold

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Reker, D, Siebuhr, A S, Thudium, C S, Gantzel, T, Ladel, C, Michaelis, M, Aspberg, A, Berchtold, M W, Karsdal, M A, Gigout, A & Bay-Jensen, A C 2020, ' Sprifermin (rhFGF18) versus vehicle induces a biphasic process of extracellular matrix remodeling in human knee OA articular cartilage ex vivo ', Scientific Reports, vol. 10, 6011 . https://doi.org/10.1038/s41598-020-63216-z
Scientific Reports

Sprifermin, recombinant human fibroblast growth factor 18 (rhFGF18), induces cartilage regeneration in knees of patients with osteoarthritis (OA). We hypothesized that a temporal multiphasic process of extracellular matrix (ECM) degradation and forma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64bb0e393b365d10b8e54bd79b3bccc4
https://doi.org/10.1038/s41598-020-63216-z

The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and Metastasis

Autor: Martin W. Berchtold, Antonio Villalobo

Publikováno v: Villalobo, A & Berchtold, M W 2020, ' The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and Metastasis ', International Journal of Molecular Sciences (Online), vol. 21, no. 3, 765 . https://doi.org/10.3390/ijms21030765
International Journal of Molecular Sciences, Vol 21, Iss 3, p 765 (2020)
International Journal of Molecular Sciences

Calmodulin (CaM) is the principal Ca2+ sensor protein in all eukaryotic cells, that upon binding to target proteins transduces signals encoded by global or subcellular-specific changes of Ca2+ concentration within the cell. The Ca2+/CaM complex as we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a75638c3274ee1a7d9cfd3b0f1f3d11
https://curis.ku.dk/portal/da/publications/the-role-of-calmodulin-in-tumor-cell-migration-invasiveness-and-metastasis(aafbbf91-af1e-4613-896e-d7e2d7250889).html

Impact of arrhythmogenic calmodulin variants on small conductance Ca2+‐activated K+ (SK3) channels

Autor: Martin W. Berchtold, Thomas Jespersen, Jonas M. la Cour, Kalai Mangai Muthukumarasamy, Arnela Saljic, Kim Boddum, Morten Grunnet

Publikováno v: Physiological Reports, Vol 7, Iss 19, Pp n/a-n/a (2019)
Saljic, A, Muthukumarasamy, K M, la Cour, J M, Boddum, K, Grunnet, M, Berchtold, M W & Jespersen, T 2019, ' Impact of arrhythmogenic calmodulin variants on small conductance Ca 2+-activated K + (SK3) channels ', Physiological Reports, vol. 7, no. 19, e14210 . https://doi.org/10.14814/phy2.14210

Calmodulin (CaM) is a ubiquitous Ca2+‐sensing protein regulating many important cellular processes. Several CaM‐associated variants have been identified in a small group of patients with cardiac arrhythmias. The mechanism remains largely unknown,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe47b75838c954785a1498a0896531e
https://doaj.org/article/03d575e3576a47a9ba14a907dda893e0